SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1agr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NHZ_A_486A800_1
(GLUCOCORTICOID
RECEPTOR)		 1agr RGS4
(Rattus
norvegicus) 		5 / 12 LEU E  73
GLY E  72
LEU E  63
MET E 160
LEU E  80
 None
 1.34A 1nhzA-1agrE:
undetectable		 1nhzA-1agrE:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_C_FUAC701_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1agr RGS4
(Rattus
norvegicus) 		5 / 12 PHE E 149
SER E 138
LEU E 129
VAL E 127
PHE E  91
 None
 1.38A 1q23C-1agrE:
undetectable		 1q23C-1agrE:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_D_FUAD705_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1agr RGS4
(Rattus
norvegicus) 		5 / 12 PHE E 149
SER E 138
LEU E 129
VAL E 127
PHE E  91
 None
 1.49A 1q23D-1agrE:
undetectable
1q23E-1agrE:
undetectable		 1q23D-1agrE:
20.78
1q23E-1agrE:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_E_FUAE706_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1agr RGS4
(Rattus
norvegicus) 		5 / 10 PHE E 149
SER E 138
LEU E 129
VAL E 127
PHE E  91
 None
 1.44A 1q23E-1agrE:
undetectable		 1q23E-1agrE:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_G_FUAG708_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1agr RGS4
(Rattus
norvegicus) 		5 / 11 PHE E 149
SER E 138
LEU E 129
VAL E 127
PHE E  91
 None
 1.46A 1q23G-1agrE:
undetectable		 1q23G-1agrE:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_K_FUAK712_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1agr RGS4
(Rattus
norvegicus) 		5 / 10 PHE E 149
SER E 138
LEU E 129
VAL E 127
PHE E  91
 None
 1.44A 1q23K-1agrE:
undetectable		 1q23K-1agrE:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_I_CLMI221_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1agr RGS4
(Rattus
norvegicus) 		5 / 10 PHE E 149
SER E 138
LEU E 129
VAL E 127
PHE E  91
 None
 1.45A 3u9fI-1agrE:
undetectable		 3u9fI-1agrE:
20.78