SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1aha'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MRG_A_ADNA300_1
(ALPHA-MOMORCHARIN)		 1aha ALPHA-MOMORCHARIN
(Momordica
charantia) 		8 / 9 ILE A  71
PHE A  83
GLY A 109
TYR A 111
ILE A 155
ALA A 159
GLU A 160
ARG A 163
 ADE  A 339 (-3.9A)
ADE  A 339 ( 4.8A)
ADE  A 339 (-4.1A)
ADE  A 339 ( 3.6A)
ADE  A 339 (-4.1A)
ADE  A 339 ( 3.7A)
ADE  A 339 (-4.5A)
ADE  A 339 ( 2.9A)
 0.30A 1mrgA-1ahaA:
43.5		 1mrgA-1ahaA:
98.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MRG_A_ADNA300_1
(ALPHA-MOMORCHARIN)		 1aha ALPHA-MOMORCHARIN
(Momordica
charantia) 		5 / 9 TYR A  70
ILE A  71
TYR A 111
ILE A 155
ALA A 159
 ADE  A 339 ( 3.8A)
ADE  A 339 (-3.9A)
ADE  A 339 ( 3.6A)
ADE  A 339 (-4.1A)
ADE  A 339 ( 3.7A)
 1.06A 1mrgA-1ahaA:
43.5		 1mrgA-1ahaA:
98.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MRJ_A_ADNA300_1
(ALPHA-TRICHOSANTHIN)		 1aha ALPHA-MOMORCHARIN
(Momordica
charantia) 		6 / 8 ILE A  71
GLY A 109
TYR A 111
ILE A 155
GLU A 160
ARG A 163
 ADE  A 339 (-3.9A)
ADE  A 339 (-4.1A)
ADE  A 339 ( 3.6A)
ADE  A 339 (-4.1A)
ADE  A 339 (-4.5A)
ADE  A 339 ( 2.9A)
 0.28A 1mrjA-1ahaA:
41.4		 1mrjA-1ahaA:
65.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MRJ_A_ADNA300_1
(ALPHA-TRICHOSANTHIN)		 1aha ALPHA-MOMORCHARIN
(Momordica
charantia) 		4 / 8 TYR A  70
ILE A  71
TYR A 111
ILE A 155
 ADE  A 339 ( 3.8A)
ADE  A 339 (-3.9A)
ADE  A 339 ( 3.6A)
ADE  A 339 (-4.1A)
 0.86A 1mrjA-1ahaA:
41.4		 1mrjA-1ahaA:
65.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_C_BEZC505_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 1aha ALPHA-MOMORCHARIN
(Momordica
charantia) 		4 / 6 TYR A 166
ILE A 186
PRO A 181
GLU A 189
 None
 1.45A 1oniA-1ahaA:
undetectable
1oniC-1ahaA:
undetectable		 1oniA-1ahaA:
21.14
1oniC-1ahaA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y0X_X_T44X500_1
(THYROID HORMONE
RECEPTOR BETA-1)		 1aha ALPHA-MOMORCHARIN
(Momordica
charantia) 		5 / 12 ILE A  18
ILE A 127
MET A  50
PHE A  17
PHE A   4
 None
 1.39A 1y0xX-1ahaA:
0.0		 1y0xX-1ahaA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNI_A_MTKA501_2
(CYTOCHROME P450 2C8)		 1aha ALPHA-MOMORCHARIN
(Momordica
charantia) 		4 / 8 ILE A 155
ILE A 167
ILE A 125
ASN A 110
 ADE  A 339 (-4.1A)
None
None
None
 0.66A 2nniA-1ahaA:
0.0		 2nniA-1ahaA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_E_MTXE621_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 1aha ALPHA-MOMORCHARIN
(Momordica
charantia) 		5 / 12 ALA A  91
PHE A  83
SER A 108
ILE A 155
LEU A 114
 None
ADE  A 339 ( 4.8A)
None
ADE  A 339 (-4.1A)
None
 1.02A 2oipE-1ahaA:
undetectable		 2oipE-1ahaA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_B_CHDB501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1aha ALPHA-MOMORCHARIN
(Momordica
charantia) 		5 / 12 LEU A 239
LEU A  37
ILE A  18
VAL A  41
VAL A  64
 None
 1.33A 2pnjB-1ahaA:
undetectable		 2pnjB-1ahaA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_A_CHDA501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1aha ALPHA-MOMORCHARIN
(Momordica
charantia) 		5 / 12 LEU A 239
LEU A  37
ILE A  18
VAL A  41
VAL A  64
 None
 1.22A 2po5A-1ahaA:
undetectable		 2po5A-1ahaA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLC_A_CHDA332_0
(CHOLOYLGLYCINE
HYDROLASE)		 1aha ALPHA-MOMORCHARIN
(Momordica
charantia) 		5 / 12 ILE A  60
THR A 157
ASN A  54
ILE A 127
LEU A   6
 None
 1.16A 2rlcA-1ahaA:
0.0		 2rlcA-1ahaA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YFX_A_VGHA9000_1
(TYROSINE-PROTEIN
KINASE RECEPTOR)		 1aha ALPHA-MOMORCHARIN
(Momordica
charantia) 		4 / 8 LEU A 129
ALA A   9
GLY A  57
ASP A  56
 None
 0.62A 2yfxA-1ahaA:
undetectable		 2yfxA-1ahaA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_D_ROCD201_2
(HIV-1 PROTEASE)		 1aha ALPHA-MOMORCHARIN
(Momordica
charantia) 		4 / 4 GLY A   8
ASP A  10
GLY A  15
THR A 157
 None
 0.97A 3k4vC-1ahaA:
undetectable		 3k4vC-1ahaA:
21.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3U6T_A_KANA4699_1
(RIBOSOME
INACTIVATING PROTEIN)		 1aha ALPHA-MOMORCHARIN
(Momordica
charantia) 		9 / 10 ILE A  71
GLU A  85
SER A 108
ASN A 110
TYR A 111
ILE A 155
ALA A 159
GLU A 160
ARG A 163
 ADE  A 339 (-3.9A)
None
None
None
ADE  A 339 ( 3.6A)
ADE  A 339 (-4.1A)
ADE  A 339 ( 3.7A)
ADE  A 339 (-4.5A)
ADE  A 339 ( 2.9A)
 0.68A 3u6tA-1ahaA:
43.7		 3u6tA-1ahaA:
94.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3U6T_A_KANA4699_1
(RIBOSOME
INACTIVATING PROTEIN)		 1aha ALPHA-MOMORCHARIN
(Momordica
charantia) 		8 / 10 TYR A  70
ILE A  71
GLU A  85
SER A 108
ASN A 110
ALA A 159
GLU A 160
ARG A 163
 ADE  A 339 ( 3.8A)
ADE  A 339 (-3.9A)
None
None
None
ADE  A 339 ( 3.7A)
ADE  A 339 (-4.5A)
ADE  A 339 ( 2.9A)
 0.85A 3u6tA-1ahaA:
43.7		 3u6tA-1ahaA:
94.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4JTP_A_ASCA802_0
(RRNA N-GLYCOSIDASE)		 1aha ALPHA-MOMORCHARIN
(Momordica
charantia) 		4 / 5 ILE A  71
ASN A 110
TYR A 111
ILE A 155
 ADE  A 339 (-3.9A)
None
ADE  A 339 ( 3.6A)
ADE  A 339 (-4.1A)
 0.22A 4jtpA-1ahaA:
43.9		 4jtpA-1ahaA:
94.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4O0O_A_URFA303_1
(RRNA N-GLYCOSIDASE)		 1aha ALPHA-MOMORCHARIN
(Momordica
charantia) 		5 / 5 TYR A  70
ASN A 110
TYR A 111
ILE A 155
ARG A 163
 ADE  A 339 ( 3.8A)
None
ADE  A 339 ( 3.6A)
ADE  A 339 (-4.1A)
ADE  A 339 ( 2.9A)
 0.52A 4o0oA-1ahaA:
43.7		 4o0oA-1ahaA:
94.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R3A_A_RBFA402_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 1aha ALPHA-MOMORCHARIN
(Momordica
charantia) 		5 / 12 ALA A 150
ALA A  76
ILE A  60
ILE A 103
LEU A 105
 None
 1.17A 4r3aA-1ahaA:
undetectable		 4r3aA-1ahaA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U15_A_0HKA2001_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,LYSOZYME,MUSCARIN
IC ACETYLCHOLINE
RECEPTOR M3)		 1aha ALPHA-MOMORCHARIN
(Momordica
charantia) 		3 / 3 ASN A  84
PHE A  82
TYR A  74
 None
 0.81A 4u15A-1ahaA:
undetectable		 4u15A-1ahaA:
21.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YP2_B_NCAB302_0
(RIBOSOME-INACTIVATIN
G PROTEIN MOMORDIN I)		 1aha ALPHA-MOMORCHARIN
(Momordica
charantia) 		9 / 9 TYR A  70
ILE A  71
PHE A  83
GLY A 109
TYR A 111
ILE A 155
ALA A 159
GLU A 160
ARG A 163
 ADE  A 339 ( 3.8A)
ADE  A 339 (-3.9A)
ADE  A 339 ( 4.8A)
ADE  A 339 (-4.1A)
ADE  A 339 ( 3.6A)
ADE  A 339 (-4.1A)
ADE  A 339 ( 3.7A)
ADE  A 339 (-4.5A)
ADE  A 339 ( 2.9A)
 0.29A 4yp2B-1ahaA:
43.8		 4yp2B-1ahaA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5CF9_B_NCAB302_0
(RIBOSOME-INACTIVATIN
G PROTEIN MOMORDIN I)		 1aha ALPHA-MOMORCHARIN
(Momordica
charantia) 		9 / 9 TYR A  70
ILE A  71
PHE A  83
GLY A 109
TYR A 111
ILE A 155
ALA A 159
GLU A 160
ARG A 163
 ADE  A 339 ( 3.8A)
ADE  A 339 (-3.9A)
ADE  A 339 ( 4.8A)
ADE  A 339 (-4.1A)
ADE  A 339 ( 3.6A)
ADE  A 339 (-4.1A)
ADE  A 339 ( 3.7A)
ADE  A 339 (-4.5A)
ADE  A 339 ( 2.9A)
 0.24A 5cf9B-1ahaA:
44.0		 5cf9B-1ahaA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5Z3J_A_NCAA302_0
(ABRIN A-CHAIN)		 1aha ALPHA-MOMORCHARIN
(Momordica
charantia) 		5 / 6 TYR A  70
TYR A 111
ILE A 155
GLU A 160
ARG A 163
 ADE  A 339 ( 3.8A)
ADE  A 339 ( 3.6A)
ADE  A 339 (-4.1A)
ADE  A 339 (-4.5A)
ADE  A 339 ( 2.9A)
 0.24A 5z3jA-1ahaA:
34.3		 5z3jA-1ahaA:
31.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5Z_D_9CRD501_0
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1aha ALPHA-MOMORCHARIN
(Momordica
charantia) 		5 / 12 ALA A 135
ALA A 150
ILE A 155
LEU A 132
ALA A 131
 None
None
ADE  A 339 (-4.1A)
None
None
 1.10A 6a5zD-1ahaA:
undetectable		 6a5zD-1ahaA:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC608_1
(ALPHA-AMYLASE)		 1aha ALPHA-MOMORCHARIN
(Momordica
charantia) 		3 / 3 TYR A 142
ALA A 150
LEU A 151
 None
 0.60A 6ag0C-1ahaA:
undetectable		 6ag0C-1ahaA:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F88_A_STRA502_1
(CYTOCHROME P450
CYP260A1)		 1aha ALPHA-MOMORCHARIN
(Momordica
charantia) 		4 / 6 PHE A  83
LEU A 105
SER A 144
THR A 138
 ADE  A 339 ( 4.8A)
None
None
None
 0.98A 6f88A-1ahaA:
0.0		 6f88A-1ahaA:
16.67