SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ahi'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EII_A_RTLA135_1
(CELLULAR
RETINOL-BINDING
PROTEIN II)		 1ahi 7
ALPHA-HYDROXYSTEROID
DEHYDROGENASE
(Escherichia
coli) 		4 / 7 GLN A 252
THR A 213
SER A 247
GLN A 207
 None
 1.43A 1eiiA-1ahiA:
0.0		 1eiiA-1ahiA:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HMY_A_SAMA328_0
(HAEIII
METHYLTRANSFERASE)		 1ahi 7
ALPHA-HYDROXYSTEROID
DEHYDROGENASE
(Escherichia
coli) 		4 / 8 ASP A  68
ILE A  69
THR A  70
LEU A 117
 NAI  A 302 (-3.6A)
NAI  A 302 (-3.8A)
NAI  A 302 ( 4.0A)
None
 0.83A 1hmyA-1ahiA:
2.2		 1hmyA-1ahiA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QAO_A_SAMA245_0
(ERMC'
METHYLTRANSFERASE)		 1ahi 7
ALPHA-HYDROXYSTEROID
DEHYDROGENASE
(Escherichia
coli) 		5 / 12 GLY A  18
GLY A  20
ILE A  43
ASP A  68
ILE A  69
 NAI  A 302 (-3.6A)
NAI  A 302 ( 4.1A)
NAI  A 302 (-4.0A)
NAI  A 302 (-3.6A)
NAI  A 302 (-3.8A)
 0.66A 1qaoA-1ahiA:
6.1		 1qaoA-1ahiA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XF1_B_ACTB1108_0
(C5A PEPTIDASE)		 1ahi 7
ALPHA-HYDROXYSTEROID
DEHYDROGENASE
(Escherichia
coli) 		4 / 6 GLY A  97
ASN A 118
ILE A  69
PHE A 122
 NAI  A 302 (-3.5A)
None
NAI  A 302 (-3.8A)
None
 0.85A 1xf1B-1ahiA:
1.9		 1xf1B-1ahiA:
13.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_E_SAME301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 1ahi 7
ALPHA-HYDROXYSTEROID
DEHYDROGENASE
(Escherichia
coli) 		5 / 12 GLY A  18
ASP A  42
ASP A  68
ASN A  95
ALA A  96
 NAI  A 302 (-3.6A)
NAI  A 302 (-2.6A)
NAI  A 302 (-3.6A)
NAI  A 302 (-3.8A)
NAI  A 302 ( 4.3A)
 1.03A 2bm9E-1ahiA:
5.9		 2bm9E-1ahiA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_A_SAMA1001_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 1ahi 7
ALPHA-HYDROXYSTEROID
DEHYDROGENASE
(Escherichia
coli) 		3 / 3 ASP A  42
ASP A  46
ASP A  68
 NAI  A 302 (-2.6A)
None
NAI  A 302 (-3.6A)
 0.69A 2igtA-1ahiA:
8.4		 2igtA-1ahiA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_B_SAMB1002_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 1ahi 7
ALPHA-HYDROXYSTEROID
DEHYDROGENASE
(Escherichia
coli) 		3 / 3 ASP A  42
ASP A  46
ASP A  68
 NAI  A 302 (-2.6A)
None
NAI  A 302 (-3.6A)
 0.69A 2igtB-1ahiA:
8.3		 2igtB-1ahiA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AY0_A_ADNA401_1
(UNCHARACTERIZED
PROTEIN MJ0883)		 1ahi 7
ALPHA-HYDROXYSTEROID
DEHYDROGENASE
(Escherichia
coli) 		5 / 10 ASP A  42
ILE A  43
ASN A  44
ALA A  47
ASP A  68
 NAI  A 302 (-2.6A)
NAI  A 302 (-4.0A)
None
NAI  A 302 ( 4.9A)
NAI  A 302 (-3.6A)
 0.59A 3ay0A-1ahiA:
6.9		 3ay0A-1ahiA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AY0_B_ADNB402_1
(UNCHARACTERIZED
PROTEIN MJ0883)		 1ahi 7
ALPHA-HYDROXYSTEROID
DEHYDROGENASE
(Escherichia
coli) 		5 / 10 GLY A  20
ASP A  42
ILE A  43
ASN A  44
ASP A  68
 NAI  A 302 ( 4.1A)
NAI  A 302 (-2.6A)
NAI  A 302 (-4.0A)
None
NAI  A 302 (-3.6A)
 0.54A 3ay0B-1ahiA:
7.4		 3ay0B-1ahiA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DOU_A_SAMA1_1
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 1ahi 7
ALPHA-HYDROXYSTEROID
DEHYDROGENASE
(Escherichia
coli) 		3 / 3 ASP A  42
ASP A  46
ASP A  68
 NAI  A 302 (-2.6A)
None
NAI  A 302 (-3.6A)
 0.78A 3douA-1ahiA:
8.9		 3douA-1ahiA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDV_A_CL6A506_1
(CHOLESTEROL
24-HYDROXYLASE)		 1ahi 7
ALPHA-HYDROXYSTEROID
DEHYDROGENASE
(Escherichia
coli) 		5 / 9 LEU A   9
PHE A  31
LEU A 142
ILE A  27
ALA A 225
 None
 1.15A 3mdvA-1ahiA:
0.0		 3mdvA-1ahiA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_C_SUEC1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 1ahi 7
ALPHA-HYDROXYSTEROID
DEHYDROGENASE
(Escherichia
coli) 		5 / 12 GLY A  87
ASP A  90
ILE A  55
ALA A  36
ALA A  32
 None
 1.01A 3sudC-1ahiA:
undetectable		 3sudC-1ahiA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 1ahi 7
ALPHA-HYDROXYSTEROID
DEHYDROGENASE
(Escherichia
coli) 		5 / 12 GLY A  87
ASP A  90
ILE A  55
ALA A  36
ALA A  32
 None
 1.02A 3sueA-1ahiA:
undetectable		 3sueA-1ahiA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6D_A_SAMA1350_0
(HYDROXYINDOLE
O-METHYLTRANSFERASE)		 1ahi 7
ALPHA-HYDROXYSTEROID
DEHYDROGENASE
(Escherichia
coli) 		5 / 12 GLY A  24
GLY A  20
ILE A  29
VAL A  51
ALA A  96
 None
NAI  A 302 ( 4.1A)
None
None
NAI  A 302 ( 4.3A)
 1.14A 4a6dA-1ahiA:
5.8		 4a6dA-1ahiA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6E_A_SAMA1349_0
(HYDROXYINDOLE
O-METHYLTRANSFERASE)		 1ahi 7
ALPHA-HYDROXYSTEROID
DEHYDROGENASE
(Escherichia
coli) 		5 / 12 GLY A  24
GLY A  20
ILE A  29
VAL A  51
ALA A  96
 None
NAI  A 302 ( 4.1A)
None
None
NAI  A 302 ( 4.3A)
 1.17A 4a6eA-1ahiA:
4.4		 4a6eA-1ahiA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_B_DXCB1473_0
(MJ0495-LIKE PROTEIN)		 1ahi 7
ALPHA-HYDROXYSTEROID
DEHYDROGENASE
(Escherichia
coli) 		5 / 11 ILE A  27
ILE A  23
GLY A  22
VAL A 246
GLY A 219
 None
NAI  A 302 (-4.0A)
NAI  A 302 (-3.5A)
None
None
 0.91A 4ac9B-1ahiA:
6.4
4ac9C-1ahiA:
6.2		 4ac9B-1ahiA:
22.66
4ac9C-1ahiA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV0_A_SAMA302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 1ahi 7
ALPHA-HYDROXYSTEROID
DEHYDROGENASE
(Escherichia
coli) 		5 / 12 GLY A  18
GLY A  20
ILE A  43
ILE A  69
LEU A 117
 NAI  A 302 (-3.6A)
NAI  A 302 ( 4.1A)
NAI  A 302 (-4.0A)
NAI  A 302 (-3.8A)
None
 1.03A 4iv0A-1ahiA:
7.3		 4iv0A-1ahiA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV0_B_SAMB302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 1ahi 7
ALPHA-HYDROXYSTEROID
DEHYDROGENASE
(Escherichia
coli) 		5 / 12 GLY A  18
GLY A  20
ILE A  43
ASP A  68
ILE A  69
 NAI  A 302 (-3.6A)
NAI  A 302 ( 4.1A)
NAI  A 302 (-4.0A)
NAI  A 302 (-3.6A)
NAI  A 302 (-3.8A)
 0.75A 4iv0B-1ahiA:
7.4		 4iv0B-1ahiA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV8_A_SAMA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 1ahi 7
ALPHA-HYDROXYSTEROID
DEHYDROGENASE
(Escherichia
coli) 		7 / 12 GLY A  18
GLY A  20
ASP A  42
ILE A  43
ASP A  68
ALA A  96
LEU A 117
 NAI  A 302 (-3.6A)
NAI  A 302 ( 4.1A)
NAI  A 302 (-2.6A)
NAI  A 302 (-4.0A)
NAI  A 302 (-3.6A)
NAI  A 302 ( 4.3A)
None
 1.37A 4iv8A-1ahiA:
7.2		 4iv8A-1ahiA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV8_A_SAMA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 1ahi 7
ALPHA-HYDROXYSTEROID
DEHYDROGENASE
(Escherichia
coli) 		7 / 12 GLY A  18
GLY A  20
ASP A  42
ILE A  43
ASP A  68
ILE A  69
LEU A 117
 NAI  A 302 (-3.6A)
NAI  A 302 ( 4.1A)
NAI  A 302 (-2.6A)
NAI  A 302 (-4.0A)
NAI  A 302 (-3.6A)
NAI  A 302 (-3.8A)
None
 0.96A 4iv8A-1ahiA:
7.2		 4iv8A-1ahiA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV8_B_SAMB301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 1ahi 7
ALPHA-HYDROXYSTEROID
DEHYDROGENASE
(Escherichia
coli) 		7 / 12 GLY A  18
GLY A  20
ASP A  42
ILE A  43
ASP A  68
ALA A  96
LEU A 117
 NAI  A 302 (-3.6A)
NAI  A 302 ( 4.1A)
NAI  A 302 (-2.6A)
NAI  A 302 (-4.0A)
NAI  A 302 (-3.6A)
NAI  A 302 ( 4.3A)
None
 1.33A 4iv8B-1ahiA:
6.7		 4iv8B-1ahiA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV8_B_SAMB301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 1ahi 7
ALPHA-HYDROXYSTEROID
DEHYDROGENASE
(Escherichia
coli) 		7 / 12 GLY A  18
GLY A  20
ASP A  42
ILE A  43
ASP A  68
ILE A  69
LEU A 117
 NAI  A 302 (-3.6A)
NAI  A 302 ( 4.1A)
NAI  A 302 (-2.6A)
NAI  A 302 (-4.0A)
NAI  A 302 (-3.6A)
NAI  A 302 (-3.8A)
None
 0.96A 4iv8B-1ahiA:
6.7		 4iv8B-1ahiA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_A_SAMA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 1ahi 7
ALPHA-HYDROXYSTEROID
DEHYDROGENASE
(Escherichia
coli) 		5 / 12 GLY A  18
GLY A  20
ILE A  43
ILE A  69
LEU A 117
 NAI  A 302 (-3.6A)
NAI  A 302 ( 4.1A)
NAI  A 302 (-4.0A)
NAI  A 302 (-3.8A)
None
 1.04A 4mwzA-1ahiA:
7.5		 4mwzA-1ahiA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_B_SAMB301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 1ahi 7
ALPHA-HYDROXYSTEROID
DEHYDROGENASE
(Escherichia
coli) 		5 / 12 GLY A  18
GLY A  20
ILE A  43
ILE A  69
LEU A 117
 NAI  A 302 (-3.6A)
NAI  A 302 ( 4.1A)
NAI  A 302 (-4.0A)
NAI  A 302 (-3.8A)
None
 1.04A 4mwzB-1ahiA:
7.3		 4mwzB-1ahiA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_B_SAMB301_0
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 1ahi 7
ALPHA-HYDROXYSTEROID
DEHYDROGENASE
(Escherichia
coli) 		5 / 12 GLY A  18
GLY A  20
ILE A  43
ILE A  23
ARG A 113
 NAI  A 302 (-3.6A)
NAI  A 302 ( 4.1A)
NAI  A 302 (-4.0A)
NAI  A 302 (-4.0A)
None
 1.13A 4qtuB-1ahiA:
6.3		 4qtuB-1ahiA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJ8_A_SUVA2001_2
(HUMAN OX1R FUSION
PROTEIN TO P.ABYSII
GLYCOGEN SYNTHASE)		 1ahi 7
ALPHA-HYDROXYSTEROID
DEHYDROGENASE
(Escherichia
coli) 		4 / 6 ILE A 192
PRO A 221
ILE A  16
VAL A  93
 NAI  A 302 (-4.1A)
None
None
None
 1.00A 4zj8A-1ahiA:
6.1		 4zj8A-1ahiA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FA8_A_SAMA301_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE,
PUTATIVE)		 1ahi 7
ALPHA-HYDROXYSTEROID
DEHYDROGENASE
(Escherichia
coli) 		5 / 12 GLY A  18
GLY A  20
ILE A  27
ILE A  43
ASN A  44
 NAI  A 302 (-3.6A)
NAI  A 302 ( 4.1A)
None
NAI  A 302 (-4.0A)
None
 0.78A 5fa8A-1ahiA:
7.1		 5fa8A-1ahiA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_A_P06A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1ahi 7
ALPHA-HYDROXYSTEROID
DEHYDROGENASE
(Escherichia
coli) 		4 / 7 ILE A  27
GLY A  24
PHE A  81
PHE A  63
 None
 1.06A 5hieA-1ahiA:
undetectable		 5hieA-1ahiA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OSP_A_ACTA403_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 1ahi 7
ALPHA-HYDROXYSTEROID
DEHYDROGENASE
(Escherichia
coli) 		4 / 7 VAL A  93
ILE A  91
VAL A  38
ALA A  14
 None
 0.76A 5ospA-1ahiA:
0.0		 5ospA-1ahiA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WY0_A_SAMA800_0
(SMALL RNA
2'-O-METHYLTRANSFERA
SE)		 1ahi 7
ALPHA-HYDROXYSTEROID
DEHYDROGENASE
(Escherichia
coli) 		7 / 12 GLY A  18
GLY A  20
ASP A  42
ILE A  43
ASN A  44
ILE A  23
LEU A 117
 NAI  A 302 (-3.6A)
NAI  A 302 ( 4.1A)
NAI  A 302 (-2.6A)
NAI  A 302 (-4.0A)
None
NAI  A 302 (-4.0A)
None
 1.15A 5wy0A-1ahiA:
2.5		 5wy0A-1ahiA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WY0_A_SAMA800_0
(SMALL RNA
2'-O-METHYLTRANSFERA
SE)		 1ahi 7
ALPHA-HYDROXYSTEROID
DEHYDROGENASE
(Escherichia
coli) 		6 / 12 GLY A  18
GLY A  20
ASP A  42
ILE A  43
ASN A  44
ILE A  27
 NAI  A 302 (-3.6A)
NAI  A 302 ( 4.1A)
NAI  A 302 (-2.6A)
NAI  A 302 (-4.0A)
None
None
 1.15A 5wy0A-1ahiA:
2.5		 5wy0A-1ahiA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B3A_A_SAMA701_0
(APRA
METHYLTRANSFERASE 1)		 1ahi 7
ALPHA-HYDROXYSTEROID
DEHYDROGENASE
(Escherichia
coli) 		6 / 12 GLY A  18
GLY A  20
ASN A  44
ALA A  47
ASP A  68
ILE A  69
 NAI  A 302 (-3.6A)
NAI  A 302 ( 4.1A)
None
NAI  A 302 ( 4.9A)
NAI  A 302 (-3.6A)
NAI  A 302 (-3.8A)
 0.94A 6b3aA-1ahiA:
6.4		 6b3aA-1ahiA:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B3B_A_SAMA701_0
(APRA
METHYLTRANSFERASE 1)		 1ahi 7
ALPHA-HYDROXYSTEROID
DEHYDROGENASE
(Escherichia
coli) 		6 / 12 GLY A  18
GLY A  20
ASN A  44
ALA A  47
ASP A  68
ILE A  69
 NAI  A 302 (-3.6A)
NAI  A 302 ( 4.1A)
None
NAI  A 302 ( 4.9A)
NAI  A 302 (-3.6A)
NAI  A 302 (-3.8A)
 0.92A 6b3bA-1ahiA:
7.4		 6b3bA-1ahiA:
15.86