SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ai1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7W_A_MTXA301_1
(PTERIDINE REDUCTASE)		 1ai1 IGG1-KAPPA 59.1 FAB
(HEAVY CHAIN)
(Mus
musculus) 		5 / 12 ARG H  66
SER H  60
LEU H  20
LEU H  18
ASP H  86
 None
 1.40A 1e7wA-1ai1H:
undetectable		 1e7wA-1ai1H:
20.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1IBG_H_OBNH1_2
(IGG2B-KAPPA 40-50
FAB (HEAVY CHAIN)
IGG2B-KAPPA 40-50
FAB (LIGHT CHAIN))		 1ai1 IGG1-KAPPA 59.1 FAB
(HEAVY CHAIN)
(Mus
musculus) 		4 / 7 THR H  73
SER H  74
SER H  70
ARG H  71
 None
 1.16A 1ibgL-1ai1H:
14.4		 1ibgL-1ai1H:
31.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2D55_C_DVAC2_0
(ACTINOMYCIN D)		 1ai1 IGG1-KAPPA 59.1 FAB
(HEAVY CHAIN)
(Mus
musculus) 		3 / 3 THR H 117
PRO H 149
PRO H 118
 None
 0.90A 2d55C-1ai1H:
undetectable		 2d55C-1ai1H:
12.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TVT_A_ASCA303_0
(THAUMATIN-1)		 1ai1 IGG1-KAPPA 59.1 FAB
(HEAVY CHAIN)
(Mus
musculus) 		4 / 7 LEU H 143
SER H 188
LYS H 145
VAL H 177
 None
 1.16A 4tvtA-1ai1H:
1.3		 4tvtA-1ai1H:
22.45