SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1air'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBY_A_9CRA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1air PECTATE LYASE C
(Dickeya
chrysanthemi) 		5 / 12 ILE A  33
ALA A  36
ALA A  35
ALA A  49
VAL A  82
 None
 0.97A 1fbyA-1airA:
undetectable		 1fbyA-1airA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBY_B_9CRB1500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1air PECTATE LYASE C
(Dickeya
chrysanthemi) 		5 / 12 ILE A  33
ALA A  36
ALA A  35
ALA A  49
VAL A  82
 None
 0.97A 1fbyB-1airA:
undetectable		 1fbyB-1airA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_A_9CRA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1air PECTATE LYASE C
(Dickeya
chrysanthemi) 		5 / 12 ILE A  33
ALA A  36
ALA A  35
ALA A  49
VAL A  82
 None
 0.95A 1fm6A-1airA:
undetectable		 1fm6A-1airA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_E_9CRE1500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1air PECTATE LYASE C
(Dickeya
chrysanthemi) 		5 / 12 ILE A  33
ALA A  36
ALA A  35
ALA A  49
VAL A  82
 None
 0.99A 1xdkE-1airA:
undetectable		 1xdkE-1airA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XIU_A_9CRA201_1
(RXR-LIKE PROTEIN)		 1air PECTATE LYASE C
(Dickeya
chrysanthemi) 		5 / 12 ILE A  33
ALA A  36
ALA A  35
ALA A  49
VAL A  82
 None
 0.97A 1xiuA-1airA:
undetectable		 1xiuA-1airA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XIU_B_9CRB202_1
(RXR-LIKE PROTEIN)		 1air PECTATE LYASE C
(Dickeya
chrysanthemi) 		5 / 12 ILE A  33
ALA A  36
ALA A  35
ALA A  49
VAL A  82
 None
 0.99A 1xiuB-1airA:
undetectable		 1xiuB-1airA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PLW_A_SAMA203_1
(RIBOSOMAL RNA
METHYLTRANSFERASE,
PUTATIVE)		 1air PECTATE LYASE C
(Dickeya
chrysanthemi) 		3 / 3 SER A 196
ASP A 131
ASP A 136
 None
 0.79A 2plwA-1airA:
undetectable		 2plwA-1airA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VN0_A_TDZA501_1
(CYTOCHROME P450 2C8)		 1air PECTATE LYASE C
(Dickeya
chrysanthemi) 		5 / 12 ILE A 133
ASN A 146
LEU A 148
VAL A 115
VAL A 180
 None
 1.01A 2vn0A-1airA:
0.0		 2vn0A-1airA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOB_C_RFPC2002_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 1air PECTATE LYASE C
(Dickeya
chrysanthemi) 		5 / 12 THR A 297
ARG A 218
ASN A 243
GLY A 241
LEU A 221
 None
SO4  A1002 ( 3.2A)
None
None
SO4  A1003 (-4.6A)
 1.38A 3aobC-1airA:
undetectable		 3aobC-1airA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOD_C_RFPC2002_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 1air PECTATE LYASE C
(Dickeya
chrysanthemi) 		5 / 12 THR A 297
ARG A 218
ASN A 243
GLY A 241
LEU A 221
 None
SO4  A1002 ( 3.2A)
None
None
SO4  A1003 (-4.6A)
 1.38A 3aodC-1airA:
0.0		 3aodC-1airA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FAL_A_REAA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1air PECTATE LYASE C
(Dickeya
chrysanthemi) 		5 / 10 ILE A  33
ALA A  36
ALA A  35
ALA A  49
VAL A  82
 None
 0.91A 3falA-1airA:
undetectable		 3falA-1airA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB3_A_SAMA1102_0
(STRUCTURAL PROTEIN
VP3)		 1air PECTATE LYASE C
(Dickeya
chrysanthemi) 		5 / 12 GLY A 121
ALA A  67
PHE A 103
ALA A 168
PRO A 124
 None
 1.08A 3jb3A-1airA:
0.0		 3jb3A-1airA:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OAP_A_9CRA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1air PECTATE LYASE C
(Dickeya
chrysanthemi) 		5 / 12 ILE A  33
ALA A  36
ALA A  35
ALA A  49
VAL A  82
 None
 0.97A 3oapA-1airA:
undetectable		 3oapA-1airA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA503_1
(CYTOCHROME P450 2B4)		 1air PECTATE LYASE C
(Dickeya
chrysanthemi) 		5 / 11 ILE A 283
ILE A 252
THR A 312
VAL A 264
PRO A 263
 None
 0.87A 3tmzA-1airA:
undetectable		 3tmzA-1airA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAQ_A_ADNA401_2
(PUTATIVE ADENOSINE
KINASE)		 1air PECTATE LYASE C
(Dickeya
chrysanthemi) 		4 / 4 LEU A 123
ALA A 101
PHE A 103
ASN A 146
 None
 1.50A 3vaqA-1airA:
undetectable		 3vaqA-1airA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_A_ZPCA1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 1air PECTATE LYASE C
(Dickeya
chrysanthemi) 		4 / 7 PHE A 103
VAL A  82
ILE A  33
GLU A  60
 None
 1.05A 4a97E-1airA:
undetectable		 4a97E-1airA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_D_ZPCD1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 1air PECTATE LYASE C
(Dickeya
chrysanthemi) 		4 / 8 PHE A 103
VAL A  82
ILE A  33
GLU A  60
 None
 1.05A 4a97C-1airA:
undetectable		 4a97C-1airA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_E_ZPCE1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 1air PECTATE LYASE C
(Dickeya
chrysanthemi) 		4 / 8 PHE A 103
VAL A  82
ILE A  33
GLU A  60
 None
 0.95A 4a97D-1airA:
undetectable		 4a97D-1airA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_H_ZPCH1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 1air PECTATE LYASE C
(Dickeya
chrysanthemi) 		4 / 8 PHE A 103
VAL A  82
ILE A  33
GLU A  60
 None
 1.02A 4a97G-1airA:
undetectable		 4a97G-1airA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_I_ZPCI1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 1air PECTATE LYASE C
(Dickeya
chrysanthemi) 		4 / 7 PHE A 103
VAL A  82
ILE A  33
GLU A  60
 None
 0.93A 4a97H-1airA:
undetectable		 4a97H-1airA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_J_ZPCJ1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 1air PECTATE LYASE C
(Dickeya
chrysanthemi) 		4 / 8 PHE A 103
VAL A  82
ILE A  33
GLU A  60
 None
 1.02A 4a97I-1airA:
undetectable		 4a97I-1airA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_A_ADNA401_2
(ADENOSINE KINASE)		 1air PECTATE LYASE C
(Dickeya
chrysanthemi) 		4 / 4 LEU A 219
ILE A 252
GLY A 241
PHE A 257
 None
 1.05A 4dc3A-1airA:
undetectable		 4dc3A-1airA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HAJ_A_DXCA75_0
(PPCA)		 1air PECTATE LYASE C
(Dickeya
chrysanthemi) 		5 / 7 ILE A  32
LEU A  52
PHE A  87
LYS A  46
GLY A  47
 None
 1.40A 4hajA-1airA:
undetectable		 4hajA-1airA:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HB8_A_DXCA75_0
(PPCA)		 1air PECTATE LYASE C
(Dickeya
chrysanthemi) 		5 / 8 ILE A  32
LEU A  52
PHE A  87
LYS A  46
GLY A  47
 None
 1.33A 4hb8A-1airA:
undetectable		 4hb8A-1airA:
10.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5)		 1air PECTATE LYASE C
(Dickeya
chrysanthemi) 		4 / 7 THR A 179
ALA A   9
THR A  10
ALA A  11
 None
 0.85A 4qw0K-1airA:
undetectable		 4qw0K-1airA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5)		 1air PECTATE LYASE C
(Dickeya
chrysanthemi) 		4 / 7 THR A 179
ALA A   9
THR A  10
ALA A  11
 None
 0.85A 4qw0Y-1airA:
undetectable		 4qw0Y-1airA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AOX_F_ACTF1001_0
(ALU JO CONSENSUS RNA
SIGNAL RECOGNITION
PARTICLE 14 KDA
PROTEIN)		 1air PECTATE LYASE C
(Dickeya
chrysanthemi) 		3 / 3 TYR A   7
THR A 179
THR A 177
 None
 0.81A 5aoxE-1airA:
undetectable		 5aoxE-1airA:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DPD_B_SAMB601_0
(PROTEIN LYSINE
METHYLTRANSFERASE 1)		 1air PECTATE LYASE C
(Dickeya
chrysanthemi) 		5 / 12 TYR A 234
ASP A 194
GLN A 222
VAL A 180
VAL A 141
 None
 1.17A 5dpdB-1airA:
undetectable		 5dpdB-1airA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWU_A_BEZA1401_0
(MAGNESIUM-CHELATASE
SUBUNIT CHLH,
CHLOROPLASTIC)		 1air PECTATE LYASE C
(Dickeya
chrysanthemi) 		4 / 6 GLY A 274
THR A 275
SER A 266
VAL A 244
 None
 1.15A 5ewuA-1airA:
undetectable		 5ewuA-1airA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWU_B_BEZB1401_0
(MAGNESIUM-CHELATASE
SUBUNIT CHLH,
CHLOROPLASTIC)		 1air PECTATE LYASE C
(Dickeya
chrysanthemi) 		4 / 6 GLY A 274
THR A 275
SER A 266
VAL A 244
 None
 1.08A 5ewuB-1airA:
undetectable		 5ewuB-1airA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HI2_A_BAXA801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1air PECTATE LYASE C
(Dickeya
chrysanthemi) 		5 / 8 VAL A 340
VAL A 113
ILE A  54
ILE A  84
ILE A  29
 None
 1.31A 5hi2A-1airA:
undetectable		 5hi2A-1airA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JH7_B_6K9B503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 1air PECTATE LYASE C
(Dickeya
chrysanthemi) 		4 / 7 VAL A 135
ASN A 210
ILE A 185
VAL A 169
 None
 1.19A 5jh7C-1airA:
undetectable		 5jh7C-1airA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UAN_A_9CRA503_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1air PECTATE LYASE C
(Dickeya
chrysanthemi) 		5 / 12 ILE A  33
ALA A  36
ALA A  35
ALA A  49
VAL A  82
 None
 0.96A 5uanA-1airA:
undetectable		 5uanA-1airA:
24.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BEO_A_DHIA4_0
((DPR)PY(DHI)PKDL(DGN
))		 1air PECTATE LYASE C
(Dickeya
chrysanthemi) 		3 / 3 TYR A 184
PRO A 335
LEU A 334
 None
 0.86A 6beoA-1airA:
undetectable		 6beoA-1airA:
4.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F32_B_ACTB602_0
(AMINE OXIDASE LKCE)		 1air PECTATE LYASE C
(Dickeya
chrysanthemi) 		4 / 6 ASN A 232
TYR A 230
VAL A 227
THR A 206
 None
 1.36A 6f32B-1airA:
undetectable		 6f32B-1airA:
21.44