SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ais'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GFZ_A_CFFA940_1
(GLYCOGEN
PHOSPHORYLASE)		 1ais PROTEIN
(TRANSCRIPTION
INITIATION FACTOR
IIB)
(Pyrococcus
woesei) 		4 / 6 ASN B1196
PHE B1192
ALA B1140
GLY B1144
 None
 1.07A 1gfzA-1aisB:
undetectable		 1gfzA-1aisB:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK2_A_T44A3004_1
(SERUM ALBUMIN)		 1ais PROTEIN
(TRANSCRIPTION
INITIATION FACTOR
IIB)
(Pyrococcus
woesei) 		4 / 7 ALA B1133
GLU B1132
VAL B1154
MET B1155
 None
 0.88A 1hk2A-1aisB:
0.5		 1hk2A-1aisB:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JGS_A_SALA256_1
(MULTIPLE ANTIBIOTIC
RESISTANCE PROTEIN
MARR)		 1ais PROTEIN
(TRANSCRIPTION
INITIATION FACTOR
IIB)
(Pyrococcus
woesei) 		4 / 7 LEU B1116
THR B1120
LEU B1123
VAL B1168
 None
 0.85A 1jgsA-1aisB:
0.0		 1jgsA-1aisB:
24.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIN_A_TFPA154_1
(CALMODULIN)		 1ais PROTEIN
(TRANSCRIPTION
INITIATION FACTOR
IIB)
(Pyrococcus
woesei) 		4 / 7 LEU B1166
GLU B1132
LEU B1136
GLU B1139
 None
 1.00A 1linA-1aisB:
undetectable		 1linA-1aisB:
26.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WLK_B_SPMB1302_1
(ATP-SENSITIVE INWARD
RECTIFIER POTASSIUM
CHANNEL 10)		 1ais PROTEIN
(TRANSCRIPTION
INITIATION FACTOR
IIB)
(Pyrococcus
woesei) 		4 / 4 ALA B1254
TYR B1286
ALA B1258
TYR B1256
 None
 1.16A 2wlkA-1aisB:
undetectable
2wlkB-1aisB:
undetectable		 2wlkA-1aisB:
21.59
2wlkB-1aisB:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BCR_A_AZZA940_1
(GLYCOGEN
PHOSPHORYLASE,
MUSCLE FORM)		 1ais PROTEIN
(TRANSCRIPTION
INITIATION FACTOR
IIB)
(Pyrococcus
woesei) 		4 / 5 ASN B1196
PHE B1192
ALA B1140
GLY B1144
 None
 1.04A 3bcrA-1aisB:
undetectable		 3bcrA-1aisB:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C6G_A_VD3A701_1
(CYTOCHROME P450 2R1)		 1ais PROTEIN
(TRANSCRIPTION
INITIATION FACTOR
IIB)
(Pyrococcus
woesei) 		5 / 12 LEU B1197
ALA B1140
ALA B1161
GLY B1187
ILE B1146
 None
 1.05A 3c6gA-1aisB:
0.2		 3c6gA-1aisB:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FE1_B_PQNB840_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 1ais PROTEIN
(TRANSCRIPTION
INITIATION FACTOR
IIB)
(Pyrococcus
woesei) 		5 / 9 SER B1222
ILE B1232
ALA B1229
LEU B1255
ALA B1216
 None
 1.49A 4fe1B-1aisB:
undetectable		 4fe1B-1aisB:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_D_RBFD201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 1ais PROTEIN
(TRANSCRIPTION
INITIATION FACTOR
IIB)
(Pyrococcus
woesei) 		4 / 8 LEU B1289
VAL B1297
LEU B1261
ILE B1295
 None
 0.86A 4r38D-1aisB:
undetectable		 4r38D-1aisB:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WCX_C_SAMC503_0
(BIOTIN AND THIAMIN
SYNTHESIS ASSOCIATED)		 1ais PROTEIN
(TRANSCRIPTION
INITIATION FACTOR
IIB)
(Pyrococcus
woesei) 		5 / 12 TYR B1190
GLY B1187
GLU B1185
LEU B1125
ALA B1162
 None
 1.23A 4wcxC-1aisB:
undetectable		 4wcxC-1aisB:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XK8_B_PQNB842_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 1ais PROTEIN
(TRANSCRIPTION
INITIATION FACTOR
IIB)
(Pyrococcus
woesei) 		5 / 10 SER B1222
ILE B1232
ALA B1229
LEU B1255
ALA B1216
 None
 1.49A 4xk8B-1aisB:
undetectable		 4xk8B-1aisB:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OY0_B_PQNB1844_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 1ais PROTEIN
(TRANSCRIPTION
INITIATION FACTOR
IIB)
(Pyrococcus
woesei) 		5 / 10 SER B1222
ILE B1232
ALA B1229
LEU B1255
ALA B1216
 None
 1.47A 5oy0b-1aisB:
0.0		 5oy0b-1aisB:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_B_ECLB1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 1ais PROTEIN
(TRANSCRIPTION
INITIATION FACTOR
IIB)
(Pyrococcus
woesei) 		4 / 7 ALA B1112
ILE B1146
LEU B1145
ILE B1186
 None
 0.89A 6b5vA-1aisB:
0.0
6b5vB-1aisB:
0.0		 6b5vA-1aisB:
17.88
6b5vB-1aisB:
17.88