SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1aj6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1KIJ_A_NOVA400_1
(DNA GYRASE SUBUNIT B)		 1aj6 GYRASE
(Escherichia
coli) 		7 / 12 GLU A  50
ASP A  73
ARG A  76
ILE A  78
PRO A  79
ILE A  94
THR A 165
 NOV  A   1 (-3.8A)
NOV  A   1 (-3.5A)
NOV  A   1 (-3.5A)
NOV  A   1 (-4.1A)
NOV  A   1 (-4.2A)
NOV  A   1 ( 4.4A)
NOV  A   1 ( 4.1A)
 0.46A 1kijA-1aj6A:
28.2		 1kijA-1aj6A:
35.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1KIJ_B_NOVB444_1
(DNA GYRASE SUBUNIT B)		 1aj6 GYRASE
(Escherichia
coli) 		8 / 12 ASN A  46
GLU A  50
ASP A  73
ARG A  76
ILE A  78
PRO A  79
ILE A  94
THR A 165
 NOV  A   1 (-4.0A)
NOV  A   1 (-3.8A)
NOV  A   1 (-3.5A)
NOV  A   1 (-3.5A)
NOV  A   1 (-4.1A)
NOV  A   1 (-4.2A)
NOV  A   1 ( 4.4A)
NOV  A   1 ( 4.1A)
 0.42A 1kijB-1aj6A:
28.2		 1kijB-1aj6A:
35.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LHU_A_ESTA301_1
(SEX HORMONE-BINDING
GLOBULIN)		 1aj6 GYRASE
(Escherichia
coli) 		5 / 12 SER A  89
GLY A  77
MET A  95
LEU A 132
LEU A 154
 None
 1.04A 1lhuA-1aj6A:
0.1		 1lhuA-1aj6A:
24.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1S14_A_NOVA1300_1
(TOPOISOMERASE IV
SUBUNIT B)		 1aj6 GYRASE
(Escherichia
coli) 		7 / 12 ASN A  46
GLU A  50
ASP A  73
ARG A  76
PRO A  79
ILE A  94
THR A 165
 NOV  A   1 (-4.0A)
NOV  A   1 (-3.8A)
NOV  A   1 (-3.5A)
NOV  A   1 (-3.5A)
NOV  A   1 (-4.2A)
NOV  A   1 ( 4.4A)
NOV  A   1 ( 4.1A)
 0.51A 1s14A-1aj6A:
23.3		 1s14A-1aj6A:
39.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1S14_B_NOVB2300_1
(TOPOISOMERASE IV
SUBUNIT B)		 1aj6 GYRASE
(Escherichia
coli) 		7 / 12 ASN A  46
GLU A  50
ASP A  73
ARG A  76
PRO A  79
ALA A  90
ILE A  94
 NOV  A   1 (-4.0A)
NOV  A   1 (-3.8A)
NOV  A   1 (-3.5A)
NOV  A   1 (-3.5A)
NOV  A   1 (-4.2A)
NOV  A   1 ( 3.9A)
NOV  A   1 ( 4.4A)
 0.53A 1s14B-1aj6A:
25.4		 1s14B-1aj6A:
39.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CIZ_A_ACTA1320_0
(CHLOROPEROXIDASE)		 1aj6 GYRASE
(Escherichia
coli) 		4 / 6 ALA A 188
PHE A 216
ILE A 203
VAL A  61
 None
 0.90A 2cizA-1aj6A:
undetectable		 2cizA-1aj6A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_B_SAMB530_0
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 1aj6 GYRASE
(Escherichia
coli) 		5 / 12 ILE A 134
ALA A  47
GLY A  77
ASN A 198
LEU A 194
 None
NOV  A   1 ( 4.2A)
None
None
None
 1.03A 2y7hB-1aj6A:
undetectable		 2y7hB-1aj6A:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF509_3
(PHOSPHOLIPASE A2)		 1aj6 GYRASE
(Escherichia
coli) 		4 / 7 VAL A 120
ILE A  27
GLY A  24
ARG A  22
 None
 0.77A 3bjwF-1aj6A:
undetectable		 3bjwF-1aj6A:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DVAC10_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 1aj6 GYRASE
(Escherichia
coli) 		3 / 3 GLY A 113
GLY A  35
GLY A  28
 None
 0.42A 3bogC-1aj6A:
0.0		 3bogC-1aj6A:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DVAC10_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 1aj6 GYRASE
(Escherichia
coli) 		3 / 3 GLY A 114
GLY A  24
GLY A  28
 None
 0.42A 3bogC-1aj6A:
0.0		 3bogC-1aj6A:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_D_DVAD10_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 1aj6 GYRASE
(Escherichia
coli) 		3 / 3 GLY A 113
GLY A  35
GLY A  28
 None
 0.37A 3bogD-1aj6A:
0.0		 3bogD-1aj6A:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IW1_A_ASDA1223_1
(CYTOCHROME P450
CYP125)		 1aj6 GYRASE
(Escherichia
coli) 		5 / 12 ILE A  63
VAL A  71
ILE A  48
VAL A  44
VAL A  40
 None
 1.19A 3iw1A-1aj6A:
0.0		 3iw1A-1aj6A:
20.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LPS_A_NOVA901_1
(TOPOISOMERASE IV
SUBUNIT B)		 1aj6 GYRASE
(Escherichia
coli) 		7 / 12 ASN A  46
GLU A  50
ASP A  73
ARG A  76
PRO A  79
ILE A  94
THR A 165
 NOV  A   1 (-4.0A)
NOV  A   1 (-3.8A)
NOV  A   1 (-3.5A)
NOV  A   1 (-3.5A)
NOV  A   1 (-4.2A)
NOV  A   1 ( 4.4A)
NOV  A   1 ( 4.1A)
 0.51A 3lpsA-1aj6A:
27.3		 3lpsA-1aj6A:
32.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4URN_A_NOVA2000_1
(DNA TOPOISOMERASE
IV, B SUBUNIT)		 1aj6 GYRASE
(Escherichia
coli) 		7 / 11 ASN A  46
GLU A  50
ASP A  73
ARG A  76
PRO A  79
ILE A  94
THR A 165
 NOV  A   1 (-4.0A)
NOV  A   1 (-3.8A)
NOV  A   1 (-3.5A)
NOV  A   1 (-3.5A)
NOV  A   1 (-4.2A)
NOV  A   1 ( 4.4A)
NOV  A   1 ( 4.1A)
 0.66A 4urnA-1aj6A:
29.1		 4urnA-1aj6A:
52.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4URN_B_NOVB2000_1
(DNA TOPOISOMERASE
IV, B SUBUNIT)		 1aj6 GYRASE
(Escherichia
coli) 		7 / 11 ASN A  46
GLU A  50
ASP A  73
ARG A  76
PRO A  79
ILE A  94
THR A 165
 NOV  A   1 (-4.0A)
NOV  A   1 (-3.8A)
NOV  A   1 (-3.5A)
NOV  A   1 (-3.5A)
NOV  A   1 (-4.2A)
NOV  A   1 ( 4.4A)
NOV  A   1 ( 4.1A)
 0.56A 4urnB-1aj6A:
26.2		 4urnB-1aj6A:
52.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4URN_C_NOVC2000_1
(DNA TOPOISOMERASE
IV, B SUBUNIT)		 1aj6 GYRASE
(Escherichia
coli) 		7 / 11 ASN A  46
GLU A  50
ASP A  73
ARG A  76
PRO A  79
ILE A  94
THR A 165
 NOV  A   1 (-4.0A)
NOV  A   1 (-3.8A)
NOV  A   1 (-3.5A)
NOV  A   1 (-3.5A)
NOV  A   1 (-4.2A)
NOV  A   1 ( 4.4A)
NOV  A   1 ( 4.1A)
 0.60A 4urnC-1aj6A:
28.2		 4urnC-1aj6A:
52.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4URO_A_NOVA2000_1
(DNA GYRASE SUBUNIT B)		 1aj6 GYRASE
(Escherichia
coli) 		7 / 12 ASN A  46
GLU A  50
ASP A  73
ARG A  76
ILE A  78
PRO A  79
ILE A  94
 NOV  A   1 (-4.0A)
NOV  A   1 (-3.8A)
NOV  A   1 (-3.5A)
NOV  A   1 (-3.5A)
NOV  A   1 (-4.1A)
NOV  A   1 (-4.2A)
NOV  A   1 ( 4.4A)
 0.41A 4uroA-1aj6A:
28.5		 4uroA-1aj6A:
55.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4URO_B_NOVB2000_1
(DNA GYRASE SUBUNIT B)		 1aj6 GYRASE
(Escherichia
coli) 		7 / 12 ASN A  46
GLU A  50
ASP A  73
ARG A  76
ILE A  78
PRO A  79
ILE A  94
 NOV  A   1 (-4.0A)
NOV  A   1 (-3.8A)
NOV  A   1 (-3.5A)
NOV  A   1 (-3.5A)
NOV  A   1 (-4.1A)
NOV  A   1 (-4.2A)
NOV  A   1 ( 4.4A)
 0.50A 4uroB-1aj6A:
28.8		 4uroB-1aj6A:
55.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4URO_C_NOVC2000_1
(DNA GYRASE SUBUNIT B)		 1aj6 GYRASE
(Escherichia
coli) 		6 / 12 ASN A  46
GLU A  50
ARG A  76
PRO A  79
ALA A  91
ILE A  94
 NOV  A   1 (-4.0A)
NOV  A   1 (-3.8A)
NOV  A   1 (-3.5A)
NOV  A   1 (-4.2A)
None
NOV  A   1 ( 4.4A)
 1.36A 4uroC-1aj6A:
28.6		 4uroC-1aj6A:
55.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4URO_C_NOVC2000_1
(DNA GYRASE SUBUNIT B)		 1aj6 GYRASE
(Escherichia
coli) 		8 / 12 ASN A  46
GLU A  50
ASP A  73
ARG A  76
ILE A  78
PRO A  79
ALA A  90
ILE A  94
 NOV  A   1 (-4.0A)
NOV  A   1 (-3.8A)
NOV  A   1 (-3.5A)
NOV  A   1 (-3.5A)
NOV  A   1 (-4.1A)
NOV  A   1 (-4.2A)
NOV  A   1 ( 3.9A)
NOV  A   1 ( 4.4A)
 0.46A 4uroC-1aj6A:
28.6		 4uroC-1aj6A:
55.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4URO_D_NOVD2000_1
(DNA GYRASE SUBUNIT B)		 1aj6 GYRASE
(Escherichia
coli) 		8 / 12 ASN A  46
GLU A  50
ASP A  73
ARG A  76
ILE A  78
PRO A  79
ILE A  94
THR A 165
 NOV  A   1 (-4.0A)
NOV  A   1 (-3.8A)
NOV  A   1 (-3.5A)
NOV  A   1 (-3.5A)
NOV  A   1 (-4.1A)
NOV  A   1 (-4.2A)
NOV  A   1 ( 4.4A)
NOV  A   1 ( 4.1A)
 0.43A 4uroD-1aj6A:
28.9		 4uroD-1aj6A:
55.51