SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1aj8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK1_A_T44A3003_1
(SERUM ALBUMIN)		 1aj8 CITRATE SYNTHASE
(Pyrococcus
furiosus) 		4 / 6 ILE A 307
LYS A 256
ALA A 250
VAL A 298
 COA  A3000 (-4.4A)
COA  A3000 (-2.8A)
None
None
 0.93A 1hk1A-1aj8A:
1.6		 1hk1A-1aj8A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_A_BEZA349_0
(D-AMINO ACID OXIDASE)		 1aj8 CITRATE SYNTHASE
(Pyrococcus
furiosus) 		4 / 5 TYR A 207
TYR A 208
ILE A 102
GLY A 125
 None
 1.19A 1kifA-1aj8A:
undetectable		 1kifA-1aj8A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_B_BEZB349_0
(D-AMINO ACID OXIDASE)		 1aj8 CITRATE SYNTHASE
(Pyrococcus
furiosus) 		4 / 5 TYR A 207
TYR A 208
ILE A 102
GLY A 125
 None
 1.19A 1kifB-1aj8A:
undetectable		 1kifB-1aj8A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_C_BEZC349_0
(D-AMINO ACID OXIDASE)		 1aj8 CITRATE SYNTHASE
(Pyrococcus
furiosus) 		4 / 5 TYR A 207
TYR A 208
ILE A 102
GLY A 125
 None
 1.19A 1kifC-1aj8A:
undetectable		 1kifC-1aj8A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_D_BEZD349_0
(D-AMINO ACID OXIDASE)		 1aj8 CITRATE SYNTHASE
(Pyrococcus
furiosus) 		4 / 5 TYR A 207
TYR A 208
ILE A 102
GLY A 125
 None
 1.18A 1kifD-1aj8A:
undetectable		 1kifD-1aj8A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_E_BEZE349_0
(D-AMINO ACID OXIDASE)		 1aj8 CITRATE SYNTHASE
(Pyrococcus
furiosus) 		4 / 5 TYR A 207
TYR A 208
ILE A 102
GLY A 125
 None
 1.19A 1kifE-1aj8A:
undetectable		 1kifE-1aj8A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_F_BEZF349_0
(D-AMINO ACID OXIDASE)		 1aj8 CITRATE SYNTHASE
(Pyrococcus
furiosus) 		4 / 5 TYR A 207
TYR A 208
ILE A 102
GLY A 125
 None
 1.19A 1kifF-1aj8A:
undetectable		 1kifF-1aj8A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_G_BEZG349_0
(D-AMINO ACID OXIDASE)		 1aj8 CITRATE SYNTHASE
(Pyrococcus
furiosus) 		4 / 5 TYR A 207
TYR A 208
ILE A 102
GLY A 125
 None
 1.19A 1kifG-1aj8A:
undetectable		 1kifG-1aj8A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_H_BEZH349_0
(D-AMINO ACID OXIDASE)		 1aj8 CITRATE SYNTHASE
(Pyrococcus
furiosus) 		4 / 5 TYR A 207
TYR A 208
ILE A 102
GLY A 125
 None
 1.19A 1kifH-1aj8A:
undetectable		 1kifH-1aj8A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_D_AG2D7015_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 1aj8 CITRATE SYNTHASE
(Pyrococcus
furiosus) 		4 / 7 LEU A 212
LEU A  98
LEU A 105
GLY A 106
 None
 0.74A 1n13D-1aj8A:
0.0
1n13E-1aj8A:
undetectable		 1n13D-1aj8A:
19.06
1n13E-1aj8A:
9.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VE9_A_BEZA352_0
(D-AMINO ACID OXIDASE)		 1aj8 CITRATE SYNTHASE
(Pyrococcus
furiosus) 		4 / 5 TYR A 207
TYR A 208
ILE A 102
GLY A 125
 None
 1.16A 1ve9A-1aj8A:
undetectable		 1ve9A-1aj8A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_B_9CRB600_2
(RETINOIC ACID
RECEPTOR, BETA)		 1aj8 CITRATE SYNTHASE
(Pyrococcus
furiosus) 		3 / 3 LEU A 317
PHE A 288
ARG A 273
 None
 0.74A 1xdkB-1aj8A:
0.0		 1xdkB-1aj8A:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_F_9CRF1600_2
(RETINOIC ACID
RECEPTOR, BETA)		 1aj8 CITRATE SYNTHASE
(Pyrococcus
furiosus) 		3 / 3 LEU A 317
PHE A 288
ARG A 273
 None
 0.74A 1xdkF-1aj8A:
0.0		 1xdkF-1aj8A:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F6D_A_ACRA996_1
(GLUCOAMYLASE GLU1)		 1aj8 CITRATE SYNTHASE
(Pyrococcus
furiosus) 		4 / 7 HIS A 223
ASN A 310
ASP A 269
GLY A 224
 CIT  A1000 (-4.0A)
COA  A3000 (-3.3A)
None
CIT  A1000 (-4.2A)
 0.99A 2f6dA-1aj8A:
0.0		 2f6dA-1aj8A:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_A_STIA600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 1aj8 CITRATE SYNTHASE
(Pyrococcus
furiosus) 		4 / 6 LEU A 345
VAL A 136
VAL A 128
ILE A 215
 None
 0.94A 2hyyA-1aj8A:
undetectable		 2hyyA-1aj8A:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 1aj8 CITRATE SYNTHASE
(Pyrococcus
furiosus) 		5 / 12 GLY A 283
ILE A 332
GLY A 316
PHE A 275
ALA A 181
 None
 1.00A 3sueA-1aj8A:
undetectable		 3sueA-1aj8A:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_B_SUEB1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 1aj8 CITRATE SYNTHASE
(Pyrococcus
furiosus) 		5 / 12 GLY A 283
ILE A 332
GLY A 316
PHE A 275
ALA A 181
 None
 0.95A 3sufB-1aj8A:
undetectable		 3sufB-1aj8A:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQ6_B_ADNB401_2
(ADENOSINE KINASE,
PUTATIVE)		 1aj8 CITRATE SYNTHASE
(Pyrococcus
furiosus) 		4 / 5 LEU A  77
GLY A  76
MET A 164
ASN A 160
 None
 1.18A 3uq6B-1aj8A:
undetectable		 3uq6B-1aj8A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7T_F_5FWF1001_1
(SUPEROXIDE DISMUTASE
[CU-ZN])		 1aj8 CITRATE SYNTHASE
(Pyrococcus
furiosus) 		4 / 6 GLU A  47
LYS A  68
PRO A  59
GLU A  48
 None
 1.49A 4a7tF-1aj8A:
undetectable		 4a7tF-1aj8A:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DT8_A_ADNA401_1
(APH(2'')-ID)		 1aj8 CITRATE SYNTHASE
(Pyrococcus
furiosus) 		5 / 11 GLY A 125
ILE A 338
ILE A 215
LEU A 212
ILE A 102
 None
 1.07A 4dt8A-1aj8A:
undetectable		 4dt8A-1aj8A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DT8_B_ADNB401_1
(APH(2'')-ID)		 1aj8 CITRATE SYNTHASE
(Pyrococcus
furiosus) 		5 / 10 GLY A 125
ILE A 338
ILE A 215
LEU A 212
ILE A 102
 None
 1.01A 4dt8B-1aj8A:
undetectable		 4dt8B-1aj8A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FUB_A_ACTA311_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 1aj8 CITRATE SYNTHASE
(Pyrococcus
furiosus) 		3 / 3 TYR A 185
ARG A 337
HIS A 188
 None
CIT  A1000 (-2.9A)
CIT  A1000 (-3.8A)
 1.11A 4fubA-1aj8A:
0.0		 4fubA-1aj8A:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_D_AERD601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 1aj8 CITRATE SYNTHASE
(Pyrococcus
furiosus) 		4 / 5 GLY A 283
ASP A 284
GLU A 292
VAL A 243
 None
 0.98A 4nkvD-1aj8A:
0.0		 4nkvD-1aj8A:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1E_A_C2FA3000_0
(DIHYDROPTEROATE
SYNTHASE DHPS)		 1aj8 CITRATE SYNTHASE
(Pyrococcus
furiosus) 		5 / 12 ILE A 102
LEU A  98
GLY A 214
SER A 193
ILE A 211
 None
 0.99A 4o1eA-1aj8A:
undetectable		 4o1eA-1aj8A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTW_A_DB8A1101_2
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-3)		 1aj8 CITRATE SYNTHASE
(Pyrococcus
furiosus) 		3 / 3 LEU A 317
LEU A 184
ASN A 310
 None
None
COA  A3000 (-3.3A)
 0.62A 4otwA-1aj8A:
0.7		 4otwA-1aj8A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVD_A_SAMA502_0
(D-MYCAROSE
3-C-METHYLTRANSFERAS
E)		 1aj8 CITRATE SYNTHASE
(Pyrococcus
furiosus) 		5 / 12 TYR A 313
ILE A 307
ALA A 272
VAL A 298
ILE A 257
 None
COA  A3000 (-4.4A)
None
None
COA  A3000 (-4.0A)
 0.95A 4rvdA-1aj8A:
undetectable		 4rvdA-1aj8A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVG_A_SAMA503_0
(D-MYCAROSE
3-C-METHYLTRANSFERAS
E)		 1aj8 CITRATE SYNTHASE
(Pyrococcus
furiosus) 		5 / 12 TYR A 313
ILE A 307
ALA A 272
VAL A 298
ILE A 257
 None
COA  A3000 (-4.4A)
None
None
COA  A3000 (-4.0A)
 0.93A 4rvgA-1aj8A:
undetectable		 4rvgA-1aj8A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0Q_A_PX9A201_1
(BETA-LACTOGLOBULIN)		 1aj8 CITRATE SYNTHASE
(Pyrococcus
furiosus) 		3 / 3 LYS A 219
ILE A 215
ILE A 102
 None
 0.67A 4y0qA-1aj8A:
0.0		 4y0qA-1aj8A:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE2_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1aj8 CITRATE SYNTHASE
(Pyrococcus
furiosus) 		4 / 5 ALA A 186
TYR A 185
HIS A 166
PHE A 319
 None
 1.39A 4ze2A-1aj8A:
0.2		 4ze2A-1aj8A:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTI_F_LFXF101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 1aj8 CITRATE SYNTHASE
(Pyrococcus
furiosus) 		4 / 5 SER A  44
ARG A  33
GLY A  34
THR A  18
 None
 1.21A 5btiC-1aj8A:
0.0
5btiD-1aj8A:
undetectable		 5btiC-1aj8A:
22.09
5btiD-1aj8A:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECN_A_LEUA602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 1aj8 CITRATE SYNTHASE
(Pyrococcus
furiosus) 		4 / 7 ALA A 272
TYR A 265
VAL A  37
GLU A  38
 None
 1.02A 5ecnA-1aj8A:
undetectable		 5ecnA-1aj8A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECN_D_LEUD602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 1aj8 CITRATE SYNTHASE
(Pyrococcus
furiosus) 		4 / 8 ALA A 272
TYR A 265
VAL A  37
GLU A  38
 None
 0.89A 5ecnD-1aj8A:
undetectable		 5ecnD-1aj8A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_B_ZOTB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 1aj8 CITRATE SYNTHASE
(Pyrococcus
furiosus) 		5 / 12 VAL A 311
GLY A 224
PHE A 234
PHE A 319
VAL A 318
 None
CIT  A1000 (-4.2A)
None
None
None
 1.04A 6a94B-1aj8A:
1.4		 6a94B-1aj8A:
26.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC607_0
(ALPHA-AMYLASE)		 1aj8 CITRATE SYNTHASE
(Pyrococcus
furiosus) 		4 / 6 GLY A 216
GLY A 220
PRO A 221
GLY A 224
 None
None
None
CIT  A1000 (-4.2A)
 0.76A 6ag0C-1aj8A:
undetectable		 6ag0C-1aj8A:
12.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUU_A_ACTA804_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1aj8 CITRATE SYNTHASE
(Pyrococcus
furiosus) 		3 / 3 GLN A 233
TRP A 246
VAL A 243
 None
 1.08A 6auuA-1aj8A:
0.0		 6auuA-1aj8A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_D_SUED1202_0
(NS3 PROTEASE)		 1aj8 CITRATE SYNTHASE
(Pyrococcus
furiosus) 		5 / 12 GLY A 283
ILE A 332
GLY A 316
PHE A 275
ALA A 181
 None
 0.90A 6c2mD-1aj8A:
undetectable		 6c2mD-1aj8A:
10.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HLO_A_GBQA1501_1
(SUBSTANCE-P
RECEPTOR,GLGA
GLYCOGEN
SYNTHASE,SUBSTANCE-P
RECEPTOR)		 1aj8 CITRATE SYNTHASE
(Pyrococcus
furiosus) 		5 / 9 ASN A 191
ILE A 211
ILE A 215
VAL A 128
ILE A 102
 CIT  A1000 (-3.3A)
None
None
None
None
 1.26A 6hloA-1aj8A:
undetectable		 6hloA-1aj8A:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HXI_B_ACTB706_0
(SUCCINYL-COA LIGASE
(ADP-FORMING)
SUBUNIT ALPHA)		 1aj8 CITRATE SYNTHASE
(Pyrococcus
furiosus) 		4 / 5 HIS A 188
ARG A 271
PHE A 333
ARG A 337
 CIT  A1000 (-3.8A)
CIT  A1000 (-2.9A)
None
CIT  A1000 (-2.9A)
 0.77A 6hxiB-1aj8A:
14.7		 6hxiB-1aj8A:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HXI_D_ACTD703_0
(SUCCINYL-COA LIGASE
(ADP-FORMING)
SUBUNIT ALPHA)		 1aj8 CITRATE SYNTHASE
(Pyrococcus
furiosus) 		5 / 5 HIS A 188
ARG A 271
ASP A 312
PHE A 333
ARG A 337
 CIT  A1000 (-3.8A)
CIT  A1000 (-2.9A)
CIT  A1000 ( 4.1A)
None
CIT  A1000 (-2.9A)
 0.79A 6hxiD-1aj8A:
16.4		 6hxiD-1aj8A:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6J20_A_GBQA1201_0
(SUBSTANCE-P
RECEPTOR,ENDOLYSIN)		 1aj8 CITRATE SYNTHASE
(Pyrococcus
furiosus) 		5 / 12 PRO A 357
ILE A 190
TYR A 348
THR A 203
ILE A 354
 None
 1.18A 6j20A-1aj8A:
0.0		 6j20A-1aj8A:
19.78