SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ajo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_J_TRPJ81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 1ajo CIRCULARLY PERMUTED
(1-3,1-4)-BETA-D-GLU
CAN
4-GLUCANOHYDROLASE
CPA16M-127
(Paenibacillus
macerans) 		4 / 8 SER A  15
ALA A 170
THR A 203
ILE A 175
 None
 0.79A 1c9sI-1ajoA:
1.3
1c9sJ-1ajoA:
0.9		 1c9sI-1ajoA:
18.54
1c9sJ-1ajoA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_U_TRPU81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 1ajo CIRCULARLY PERMUTED
(1-3,1-4)-BETA-D-GLU
CAN
4-GLUCANOHYDROLASE
CPA16M-127
(Paenibacillus
macerans) 		4 / 8 ALA A 170
THR A 203
ILE A 175
SER A  15
 None
 0.76A 1c9sU-1ajoA:
1.3
1c9sV-1ajoA:
1.2		 1c9sU-1ajoA:
18.54
1c9sV-1ajoA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_A_TRPA81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 1ajo CIRCULARLY PERMUTED
(1-3,1-4)-BETA-D-GLU
CAN
4-GLUCANOHYDROLASE
CPA16M-127
(Paenibacillus
macerans) 		4 / 7 ALA A 170
THR A 203
ILE A 175
SER A  15
 None
 0.78A 1gtnA-1ajoA:
undetectable
1gtnK-1ajoA:
undetectable		 1gtnA-1ajoA:
18.54
1gtnK-1ajoA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_B_TRPB81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 1ajo CIRCULARLY PERMUTED
(1-3,1-4)-BETA-D-GLU
CAN
4-GLUCANOHYDROLASE
CPA16M-127
(Paenibacillus
macerans) 		4 / 8 SER A  15
ALA A 170
THR A 203
ILE A 175
 None
 0.76A 1gtnA-1ajoA:
0.0
1gtnB-1ajoA:
0.7		 1gtnA-1ajoA:
18.54
1gtnB-1ajoA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_F_TRPF81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 1ajo CIRCULARLY PERMUTED
(1-3,1-4)-BETA-D-GLU
CAN
4-GLUCANOHYDROLASE
CPA16M-127
(Paenibacillus
macerans) 		4 / 8 SER A  15
ALA A 170
THR A 203
ILE A 175
 None
 0.76A 1gtnE-1ajoA:
undetectable
1gtnF-1ajoA:
0.9		 1gtnE-1ajoA:
18.54
1gtnF-1ajoA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_P_TRPP81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 1ajo CIRCULARLY PERMUTED
(1-3,1-4)-BETA-D-GLU
CAN
4-GLUCANOHYDROLASE
CPA16M-127
(Paenibacillus
macerans) 		4 / 8 ALA A 170
THR A 203
ILE A 175
SER A  15
 None
 0.78A 1gtnP-1ajoA:
1.2
1gtnQ-1ajoA:
0.0		 1gtnP-1ajoA:
18.54
1gtnQ-1ajoA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_B_TRPB81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1ajo CIRCULARLY PERMUTED
(1-3,1-4)-BETA-D-GLU
CAN
4-GLUCANOHYDROLASE
CPA16M-127
(Paenibacillus
macerans) 		4 / 8 ALA A 170
THR A 203
ILE A 175
SER A  15
 None
 0.77A 1utdB-1ajoA:
1.1
1utdC-1ajoA:
1.4		 1utdB-1ajoA:
18.54
1utdC-1ajoA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_F_TRPF81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1ajo CIRCULARLY PERMUTED
(1-3,1-4)-BETA-D-GLU
CAN
4-GLUCANOHYDROLASE
CPA16M-127
(Paenibacillus
macerans) 		4 / 8 ALA A 170
THR A 203
ILE A 175
SER A  15
 None
 0.76A 1utdF-1ajoA:
1.4
1utdG-1ajoA:
1.2		 1utdF-1ajoA:
18.54
1utdG-1ajoA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_I_TRPI81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1ajo CIRCULARLY PERMUTED
(1-3,1-4)-BETA-D-GLU
CAN
4-GLUCANOHYDROLASE
CPA16M-127
(Paenibacillus
macerans) 		4 / 8 ALA A 170
THR A 203
ILE A 175
SER A  15
 None
 0.77A 1utdI-1ajoA:
1.4
1utdJ-1ajoA:
undetectable		 1utdI-1ajoA:
18.54
1utdJ-1ajoA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_J_TRPJ81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1ajo CIRCULARLY PERMUTED
(1-3,1-4)-BETA-D-GLU
CAN
4-GLUCANOHYDROLASE
CPA16M-127
(Paenibacillus
macerans) 		4 / 8 ALA A 170
THR A 203
ILE A 175
SER A  15
 None
 0.76A 1utdJ-1ajoA:
0.0
1utdK-1ajoA:
0.0		 1utdJ-1ajoA:
18.54
1utdK-1ajoA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_A_SAMA300_0
(PUTATIVE RRNA
METHYLASE)		 1ajo CIRCULARLY PERMUTED
(1-3,1-4)-BETA-D-GLU
CAN
4-GLUCANOHYDROLASE
CPA16M-127
(Paenibacillus
macerans) 		5 / 12 GLY A 138
ASN A 126
ASN A 128
ILE A 175
GLY A 200
 None
 1.09A 3eeyA-1ajoA:
undetectable		 3eeyA-1ajoA:
24.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_B_SAMB300_0
(PUTATIVE RRNA
METHYLASE)		 1ajo CIRCULARLY PERMUTED
(1-3,1-4)-BETA-D-GLU
CAN
4-GLUCANOHYDROLASE
CPA16M-127
(Paenibacillus
macerans) 		5 / 12 GLY A 138
ASN A 126
ASN A 128
ILE A 175
GLY A 200
 None
 1.08A 3eeyB-1ajoA:
undetectable		 3eeyB-1ajoA:
24.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_H_SAMH300_0
(PUTATIVE RRNA
METHYLASE)		 1ajo CIRCULARLY PERMUTED
(1-3,1-4)-BETA-D-GLU
CAN
4-GLUCANOHYDROLASE
CPA16M-127
(Paenibacillus
macerans) 		5 / 12 GLY A 138
ASN A 126
ASN A 128
ILE A 175
GLY A 200
 None
 1.10A 3eeyH-1ajoA:
undetectable		 3eeyH-1ajoA:
24.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_I_SAMI300_0
(PUTATIVE RRNA
METHYLASE)		 1ajo CIRCULARLY PERMUTED
(1-3,1-4)-BETA-D-GLU
CAN
4-GLUCANOHYDROLASE
CPA16M-127
(Paenibacillus
macerans) 		5 / 12 GLY A 138
ASN A 126
ASN A 128
ILE A 175
GLY A 200
 None
 1.11A 3eeyI-1ajoA:
undetectable		 3eeyI-1ajoA:
24.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ECK_B_FOLB703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1ajo CIRCULARLY PERMUTED
(1-3,1-4)-BETA-D-GLU
CAN
4-GLUCANOHYDROLASE
CPA16M-127
(Paenibacillus
macerans) 		5 / 12 VAL A 165
ALA A  22
PHE A 179
SER A 178
VAL A  83
 None
 1.19A 4eckB-1ajoA:
undetectable		 4eckB-1ajoA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M93_B_ACTB303_0
(S25-26 FAB (IGG1K)
HEAVY CHAIN
S25-26 FAB (IGG1K)
LIGHT CHAIN)		 1ajo CIRCULARLY PERMUTED
(1-3,1-4)-BETA-D-GLU
CAN
4-GLUCANOHYDROLASE
CPA16M-127
(Paenibacillus
macerans) 		4 / 5 GLY A  17
SER A  15
ALA A  14
PHE A  18
 None
 1.02A 4m93B-1ajoA:
undetectable
4m93C-1ajoA:
2.0		 4m93B-1ajoA:
20.33
4m93C-1ajoA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_A_P06A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1ajo CIRCULARLY PERMUTED
(1-3,1-4)-BETA-D-GLU
CAN
4-GLUCANOHYDROLASE
CPA16M-127
(Paenibacillus
macerans) 		3 / 3 PHE A  23
ILE A 196
ASP A  35
 None
 0.74A 5cswA-1ajoA:
0.0		 5cswA-1ajoA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_B_P06B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1ajo CIRCULARLY PERMUTED
(1-3,1-4)-BETA-D-GLU
CAN
4-GLUCANOHYDROLASE
CPA16M-127
(Paenibacillus
macerans) 		3 / 3 PHE A  23
ILE A 196
ASP A  35
 None
 0.70A 5cswB-1ajoA:
0.0		 5cswB-1ajoA:
18.79