SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ajz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RBP_A_RTLA183_0
(PLASMA
RETINOL-BINDING
PROTEIN PRECURSOR)		 1ajz DIHYDROPTEROATE
SYNTHASE
(Escherichia
coli) 		5 / 12 LEU A   3
ALA A 128
ALA A 125
ALA A 129
LEU A 182
 None
 1.21A 1rbpA-1ajzA:
undetectable		 1rbpA-1ajzA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SGU_B_MK1B2632_2
(POL POLYPROTEIN)		 1ajz DIHYDROPTEROATE
SYNTHASE
(Escherichia
coli) 		5 / 12 GLY A  58
ASP A 116
ILE A 114
ILE A 103
ILE A  79
 None
 1.02A 1sguB-1ajzA:
undetectable		 1sguB-1ajzA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XVA_A_ACTA294_0
(GLYCINE
N-METHYLTRANSFERASE)		 1ajz DIHYDROPTEROATE
SYNTHASE
(Escherichia
coli) 		4 / 5 ILE A  79
LEU A  37
ALA A  84
GLU A  83
 None
 0.99A 1xvaA-1ajzA:
undetectable
1xvaB-1ajzA:
undetectable		 1xvaA-1ajzA:
22.32
1xvaB-1ajzA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XVA_B_ACTB294_0
(GLYCINE
N-METHYLTRANSFERASE)		 1ajz DIHYDROPTEROATE
SYNTHASE
(Escherichia
coli) 		4 / 6 ALA A  84
GLU A  83
ILE A  79
LEU A  37
 None
 0.95A 1xvaA-1ajzA:
undetectable
1xvaB-1ajzA:
undetectable		 1xvaA-1ajzA:
22.32
1xvaB-1ajzA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2D55_C_DVAC8_0
(ACTINOMYCIN D)		 1ajz DIHYDROPTEROATE
SYNTHASE
(Escherichia
coli) 		3 / 3 PRO A  64
THR A 147
PRO A 145
 None
 0.80A 2d55C-1ajzA:
undetectable		 2d55C-1ajzA:
5.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNI_A_MTKA501_2
(CYTOCHROME P450 2C8)		 1ajz DIHYDROPTEROATE
SYNTHASE
(Escherichia
coli) 		4 / 8 ILE A  85
ILE A  38
ASN A  22
VAL A  23
 None
None
SO4  A 283 (-3.4A)
None
 0.69A 2nniA-1ajzA:
undetectable		 2nniA-1ajzA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNK_A_ROCA401_3
(PROTEASE)		 1ajz DIHYDROPTEROATE
SYNTHASE
(Escherichia
coli) 		5 / 12 GLY A  58
ASP A  56
ILE A 103
VAL A 109
VAL A  82
 None
 0.95A 2nnkB-1ajzA:
undetectable		 2nnkB-1ajzA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YCJ_A_C2FA3000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 1ajz DIHYDROPTEROATE
SYNTHASE
(Escherichia
coli) 		5 / 12 ASP A  56
ASN A 115
ASP A 185
GLY A 217
SER A 219
 None
 1.14A 2ycjA-1ajzA:
21.2		 2ycjA-1ajzA:
24.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDW_A_RITA100_2
(PROTEASE)		 1ajz DIHYDROPTEROATE
SYNTHASE
(Escherichia
coli) 		5 / 9 ALA A  44
GLY A  19
ILE A  20
VAL A  82
ILE A  85
 None
None
SO4  A 283 ( 4.8A)
None
None
 1.13A 3ndwB-1ajzA:
undetectable		 3ndwB-1ajzA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NV6_A_CAMA422_0
(CYTOCHROME P450)		 1ajz DIHYDROPTEROATE
SYNTHASE
(Escherichia
coli) 		3 / 3 GLY A  58
ILE A 103
VAL A 102
 None
 0.50A 3nv6A-1ajzA:
0.0		 3nv6A-1ajzA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NY4_A_SMXA310_1
(BETA-LACTAMASE)		 1ajz DIHYDROPTEROATE
SYNTHASE
(Escherichia
coli) 		4 / 8 LEU A 204
ALA A 241
GLY A 187
PRO A 186
 None
 0.94A 3ny4A-1ajzA:
undetectable		 3ny4A-1ajzA:
20.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TYE_B_YTZB902_1
(DIHYDROPTEROATE
SYNTHASE)		 1ajz DIHYDROPTEROATE
SYNTHASE
(Escherichia
coli) 		3 / 3 PHE A 190
LYS A 221
SER A 222
 None
SO4  A 283 ( 4.2A)
SO4  A 284 (-2.7A)
 0.69A 3tyeB-1ajzA:
35.7		 3tyeB-1ajzA:
38.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TZF_B_08DB280_1
(7,8-DIHYDROPTEROATE
SYNTHASE)		 1ajz DIHYDROPTEROATE
SYNTHASE
(Escherichia
coli) 		5 / 8 PRO A  64
GLY A 189
PHE A 190
LYS A 221
SER A 222
 None
None
None
SO4  A 283 ( 4.2A)
SO4  A 284 (-2.7A)
 0.93A 3tzfB-1ajzA:
41.9		 3tzfB-1ajzA:
74.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TZF_B_08DB280_1
(7,8-DIHYDROPTEROATE
SYNTHASE)		 1ajz DIHYDROPTEROATE
SYNTHASE
(Escherichia
coli) 		5 / 8 THR A  62
PRO A  64
GLY A 189
PHE A 190
SER A 222
 SO4  A 283 ( 4.9A)
None
None
None
SO4  A 284 (-2.7A)
 0.81A 3tzfB-1ajzA:
41.9		 3tzfB-1ajzA:
74.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJE_B_C2FB302_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 1ajz DIHYDROPTEROATE
SYNTHASE
(Escherichia
coli) 		6 / 12 ASP A  56
ASP A  96
ASN A 115
ASP A 185
GLY A 217
SER A 219
 None
 1.06A 4djeB-1ajzA:
21.4		 4djeB-1ajzA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HB8_A_DXCA75_0
(PPCA)		 1ajz DIHYDROPTEROATE
SYNTHASE
(Escherichia
coli) 		5 / 8 ILE A 245
LEU A 201
LYS A 221
ILE A 224
GLY A 187
 None
None
SO4  A 283 ( 4.2A)
None
None
 1.30A 4hb8A-1ajzA:
undetectable		 4hb8A-1ajzA:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MI4_A_SPMA201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 1ajz DIHYDROPTEROATE
SYNTHASE
(Escherichia
coli) 		4 / 6 ASN A 162
GLU A 167
TYR A 164
GLU A 160
 None
 1.19A 4mi4A-1ajzA:
0.5		 4mi4A-1ajzA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MI4_C_SPMC201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 1ajz DIHYDROPTEROATE
SYNTHASE
(Escherichia
coli) 		4 / 7 ASN A 162
GLU A 167
TYR A 164
GLU A 160
 None
 1.18A 4mi4A-1ajzA:
0.5
4mi4C-1ajzA:
0.6		 4mi4A-1ajzA:
22.76
4mi4C-1ajzA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_A_SPMA201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 1ajz DIHYDROPTEROATE
SYNTHASE
(Escherichia
coli) 		4 / 8 ASN A 162
GLU A 167
TYR A 164
GLU A 160
 None
 1.17A 4mj8A-1ajzA:
0.6
4mj8C-1ajzA:
0.8		 4mj8A-1ajzA:
22.46
4mj8C-1ajzA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_C_SPMC201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 1ajz DIHYDROPTEROATE
SYNTHASE
(Escherichia
coli) 		4 / 7 ASN A 162
GLU A 167
TYR A 164
GLU A 160
 None
 1.18A 4mj8C-1ajzA:
0.8		 4mj8C-1ajzA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTW_A_DB8A1101_2
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-3)		 1ajz DIHYDROPTEROATE
SYNTHASE
(Escherichia
coli) 		3 / 3 LEU A 212
LEU A 204
ASN A 162
 None
 0.70A 4otwA-1ajzA:
0.0		 4otwA-1ajzA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGH_A_SAMA401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 1ajz DIHYDROPTEROATE
SYNTHASE
(Escherichia
coli) 		5 / 11 SER A  27
GLY A  58
ASP A  96
ASP A 185
ILE A  20
 None
None
None
None
SO4  A 283 ( 4.8A)
 1.13A 4pghA-1ajzA:
undetectable		 4pghA-1ajzA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R87_I_SPMI202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 1ajz DIHYDROPTEROATE
SYNTHASE
(Escherichia
coli) 		4 / 7 ASN A 162
GLU A 167
TYR A 164
GLU A 160
 None
 1.18A 4r87I-1ajzA:
1.8		 4r87I-1ajzA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RYA_A_MTLA501_0
(ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (SORBITOL))		 1ajz DIHYDROPTEROATE
SYNTHASE
(Escherichia
coli) 		5 / 12 GLY A  51
ALA A  52
PHE A  89
ALA A  44
VAL A  41
 None
 1.47A 4ryaA-1ajzA:
0.0		 4ryaA-1ajzA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWZ_B_BEZB301_0
(14-3-3 PROTEIN
ZETA/DELTA)		 1ajz DIHYDROPTEROATE
SYNTHASE
(Escherichia
coli) 		3 / 3 MET A 223
GLN A 226
ARG A 235
 None
None
SO4  A 284 (-2.6A)
 1.12A 5ewzB-1ajzA:
undetectable		 5ewzB-1ajzA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKQ_A_JMSA602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1ajz DIHYDROPTEROATE
SYNTHASE
(Escherichia
coli) 		3 / 3 VAL A 230
SER A 237
MET A 218
 None
 0.94A 5ikqA-1ajzA:
0.0		 5ikqA-1ajzA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_A_C2FA3001_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 1ajz DIHYDROPTEROATE
SYNTHASE
(Escherichia
coli) 		3 / 3 ASP A  96
ASN A 115
ASP A 185
 None
 0.74A 5vopA-1ajzA:
18.7		 5vopA-1ajzA:
24.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_B_C2FB3001_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 1ajz DIHYDROPTEROATE
SYNTHASE
(Escherichia
coli) 		3 / 3 ASP A  96
ASN A 115
ASP A 185
 None
 0.75A 5vopB-1ajzA:
7.9		 5vopB-1ajzA:
24.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6J_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 1ajz DIHYDROPTEROATE
SYNTHASE
(Escherichia
coli) 		3 / 3 MET A 139
ASP A  96
ARG A  63
 None
None
SO4  A 283 (-3.9A)
 1.21A 5z6jA-1ajzA:
undetectable		 5z6jA-1ajzA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A60_D_9CRD501_0
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1ajz DIHYDROPTEROATE
SYNTHASE
(Escherichia
coli) 		5 / 12 ILE A 254
ALA A 246
ALA A 251
LEU A 214
ILE A  54
 None
 1.06A 6a60D-1ajzA:
undetectable		 6a60D-1ajzA:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_A_QPSA602_1
(-)		 1ajz DIHYDROPTEROATE
SYNTHASE
(Escherichia
coli) 		5 / 12 VAL A  82
ASP A 258
HIS A  43
ASN A  22
ARG A 255
 None
None
None
SO4  A 283 (-3.4A)
SO4  A 283 (-3.1A)
 1.34A 6gnfA-1ajzA:
2.9		 6gnfA-1ajzA:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_C_QPSC602_2
(-)		 1ajz DIHYDROPTEROATE
SYNTHASE
(Escherichia
coli) 		5 / 12 VAL A  82
ASP A 258
HIS A  43
ASN A  22
ARG A 255
 None
None
None
SO4  A 283 (-3.4A)
SO4  A 283 (-3.1A)
 1.38A 6gnfC-1ajzA:
3.0		 6gnfC-1ajzA:
18.08