SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ak0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E9Y_B_HAEB800_1
(UREASE SUBUNIT BETA)		 1ak0 P1 NUCLEASE
(Penicillium
citrinum) 		4 / 5 HIS A 116
HIS A 126
HIS A   6
ASP A  45
 ZN  A 271 (-3.5A)
ZN  A 272 ( 3.5A)
ZN  A 273 (-3.4A)
ZN  A 271 (-3.2A)
 0.98A 1e9yB-1ak0A:
undetectable		 1e9yB-1ak0A:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OE1_A_CUA502_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 1ak0 P1 NUCLEASE
(Penicillium
citrinum) 		3 / 3 ASP A 120
HIS A  60
HIS A 116
 ZN  A 271 ( 2.4A)
ZN  A 271 (-3.4A)
ZN  A 271 (-3.5A)
 0.69A 1oe1A-1ak0A:
undetectable		 1oe1A-1ak0A:
25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T7I_A_017A200_2
(POL POLYPROTEIN)		 1ak0 P1 NUCLEASE
(Penicillium
citrinum) 		4 / 7 ASP A 127
ALA A 212
GLY A 252
ILE A 118
 None
 0.82A 1t7iB-1ak0A:
undetectable		 1t7iB-1ak0A:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T7J_A_478A200_2
(POL POLYPROTEIN)		 1ak0 P1 NUCLEASE
(Penicillium
citrinum) 		4 / 7 ASP A 127
ALA A 212
GLY A 252
ILE A 118
 None
 0.83A 1t7jB-1ak0A:
undetectable		 1t7jB-1ak0A:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_C_DVAC6_0
(GRAMICIDIN D)		 1ak0 P1 NUCLEASE
(Penicillium
citrinum) 		3 / 3 ALA A 108
VAL A  97
TRP A  24
 None
 0.85A 1w5uC-1ak0A:
undetectable
1w5uD-1ak0A:
undetectable		 1w5uC-1ak0A:
3.85
1w5uD-1ak0A:
3.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_B_DVAB6_0
(GRAMICIDIN D)		 1ak0 P1 NUCLEASE
(Penicillium
citrinum) 		3 / 3 TRP A  24
ALA A 108
VAL A  97
 None
 0.82A 2izqA-1ak0A:
undetectable
2izqB-1ak0A:
undetectable		 2izqA-1ak0A:
3.85
2izqB-1ak0A:
3.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLC_A_GLYA333_0
(CHOLOYLGLYCINE
HYDROLASE)		 1ak0 P1 NUCLEASE
(Penicillium
citrinum) 		3 / 3 ASN A  71
ASN A  73
ARG A  78
 None
 0.95A 2rlcA-1ak0A:
undetectable		 2rlcA-1ak0A:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_D_2FAD500_1
(ADENOSYLHOMOCYSTEINA
SE)		 1ak0 P1 NUCLEASE
(Penicillium
citrinum) 		5 / 12 ASP A 153
ASP A  45
HIS A 149
GLY A 119
HIS A 116
 ZN  A 272 ( 2.1A)
ZN  A 271 (-3.2A)
THS  A 295 ( 3.4A)
None
ZN  A 271 (-3.5A)
 1.36A 2zj0D-1ak0A:
undetectable		 2zj0D-1ak0A:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_A_DVAA6_0
(GRAMICIDIN D)		 1ak0 P1 NUCLEASE
(Penicillium
citrinum) 		3 / 3 ALA A 108
VAL A  97
TRP A  24
 None
 0.83A 3l8lA-1ak0A:
undetectable
3l8lB-1ak0A:
undetectable		 3l8lA-1ak0A:
3.85
3l8lB-1ak0A:
3.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_C_DVAC6_0
(GRAMICIDIN D)		 1ak0 P1 NUCLEASE
(Penicillium
citrinum) 		3 / 3 ALA A 108
VAL A  97
TRP A  24
 None
 0.77A 3l8lC-1ak0A:
undetectable
3l8lD-1ak0A:
undetectable		 3l8lC-1ak0A:
3.85
3l8lD-1ak0A:
3.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AT0_A_ACTA1490_0
(3-KETOSTEROID-DELTA4
-5ALPHA-DEHYDROGENAS
E)		 1ak0 P1 NUCLEASE
(Penicillium
citrinum) 		3 / 3 GLU A 170
TYR A  11
SER A  35
 None
 0.77A 4at0A-1ak0A:
0.0		 4at0A-1ak0A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K38_B_SAMB504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME)		 1ak0 P1 NUCLEASE
(Penicillium
citrinum) 		5 / 12 TYR A 237
PHE A 141
GLN A 123
VAL A 241
ILE A 245
 None
 1.17A 4k38B-1ak0A:
0.0		 4k38B-1ak0A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K39_A_SAMA504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME)		 1ak0 P1 NUCLEASE
(Penicillium
citrinum) 		5 / 12 TYR A 237
PHE A 141
GLN A 123
VAL A 241
ILE A 245
 None
 1.18A 4k39A-1ak0A:
undetectable		 4k39A-1ak0A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K7G_B_ACTB902_0
(3-HYDROXYPROLINE
DEHYDRATSE)		 1ak0 P1 NUCLEASE
(Penicillium
citrinum) 		4 / 7 ASP A  45
TRP A   1
HIS A 116
SER A  42
 ZN  A 271 (-3.2A)
None
ZN  A 271 (-3.5A)
None
 1.13A 4k7gB-1ak0A:
0.0		 4k7gB-1ak0A:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V20_A_ACTA1444_0
(CELLOBIOHYDROLASE)		 1ak0 P1 NUCLEASE
(Penicillium
citrinum) 		4 / 5 GLY A 119
THR A 122
HIS A   6
GLY A   5
 None
None
ZN  A 273 (-3.4A)
None
 1.18A 4v20A-1ak0A:
undetectable		 4v20A-1ak0A:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GQB_A_GCSA605_1
(CHITINASE)		 1ak0 P1 NUCLEASE
(Penicillium
citrinum) 		3 / 3 TRP A 208
ILE A  87
SER A  86
 None
 0.97A 5gqbA-1ak0A:
undetectable		 5gqbA-1ak0A:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_A_ADNA501_1
(ADENOSYLHOMOCYSTEINA
SE)		 1ak0 P1 NUCLEASE
(Penicillium
citrinum) 		5 / 12 ASP A 153
ASP A  45
HIS A 149
GLY A 119
HIS A 116
 ZN  A 272 ( 2.1A)
ZN  A 271 (-3.2A)
THS  A 295 ( 3.4A)
None
ZN  A 271 (-3.5A)
 1.35A 5hm8A-1ak0A:
undetectable		 5hm8A-1ak0A:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_B_ADNB501_1
(ADENOSYLHOMOCYSTEINA
SE)		 1ak0 P1 NUCLEASE
(Penicillium
citrinum) 		5 / 12 ASP A 153
ASP A  45
HIS A 149
GLY A 119
HIS A 116
 ZN  A 272 ( 2.1A)
ZN  A 271 (-3.2A)
THS  A 295 ( 3.4A)
None
ZN  A 271 (-3.5A)
 1.35A 5hm8B-1ak0A:
undetectable		 5hm8B-1ak0A:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_C_ADNC501_1
(ADENOSYLHOMOCYSTEINA
SE)		 1ak0 P1 NUCLEASE
(Penicillium
citrinum) 		5 / 12 ASP A 153
ASP A  45
HIS A 149
GLY A 119
HIS A 116
 ZN  A 272 ( 2.1A)
ZN  A 271 (-3.2A)
THS  A 295 ( 3.4A)
None
ZN  A 271 (-3.5A)
 1.35A 5hm8C-1ak0A:
undetectable		 5hm8C-1ak0A:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_D_ADND501_1
(ADENOSYLHOMOCYSTEINA
SE)		 1ak0 P1 NUCLEASE
(Penicillium
citrinum) 		5 / 12 ASP A 153
ASP A  45
HIS A 149
GLY A 119
HIS A 116
 ZN  A 272 ( 2.1A)
ZN  A 271 (-3.2A)
THS  A 295 ( 3.4A)
None
ZN  A 271 (-3.5A)
 1.35A 5hm8D-1ak0A:
undetectable		 5hm8D-1ak0A:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_E_ADNE501_1
(ADENOSYLHOMOCYSTEINA
SE)		 1ak0 P1 NUCLEASE
(Penicillium
citrinum) 		5 / 12 ASP A 153
ASP A  45
HIS A 149
GLY A 119
HIS A 116
 ZN  A 272 ( 2.1A)
ZN  A 271 (-3.2A)
THS  A 295 ( 3.4A)
None
ZN  A 271 (-3.5A)
 1.35A 5hm8E-1ak0A:
undetectable		 5hm8E-1ak0A:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_F_ADNF501_1
(ADENOSYLHOMOCYSTEINA
SE)		 1ak0 P1 NUCLEASE
(Penicillium
citrinum) 		5 / 12 ASP A 153
ASP A  45
HIS A 149
GLY A 119
HIS A 116
 ZN  A 272 ( 2.1A)
ZN  A 271 (-3.2A)
THS  A 295 ( 3.4A)
None
ZN  A 271 (-3.5A)
 1.35A 5hm8F-1ak0A:
undetectable		 5hm8F-1ak0A:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_G_ADNG501_1
(ADENOSYLHOMOCYSTEINA
SE)		 1ak0 P1 NUCLEASE
(Penicillium
citrinum) 		5 / 12 ASP A 153
ASP A  45
HIS A 149
GLY A 119
HIS A 116
 ZN  A 272 ( 2.1A)
ZN  A 271 (-3.2A)
THS  A 295 ( 3.4A)
None
ZN  A 271 (-3.5A)
 1.35A 5hm8G-1ak0A:
undetectable		 5hm8G-1ak0A:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_H_ADNH501_1
(ADENOSYLHOMOCYSTEINA
SE)		 1ak0 P1 NUCLEASE
(Penicillium
citrinum) 		5 / 12 ASP A 153
ASP A  45
HIS A 149
GLY A 119
HIS A 116
 ZN  A 272 ( 2.1A)
ZN  A 271 (-3.2A)
THS  A 295 ( 3.4A)
None
ZN  A 271 (-3.5A)
 1.35A 5hm8H-1ak0A:
undetectable		 5hm8H-1ak0A:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND3_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 1ak0 P1 NUCLEASE
(Penicillium
citrinum) 		5 / 12 GLU A  46
HIS A 164
LEU A   4
ALA A   3
SER A  42
 None
 1.26A 5nd3B-1ak0A:
undetectable		 5nd3B-1ak0A:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWU_A_ACAA18_1
(WTFP-TAG,GP41)		 1ak0 P1 NUCLEASE
(Penicillium
citrinum) 		5 / 12 GLY A  30
SER A  31
ASN A 106
GLU A 109
LEU A 111
 None
None
None
NAG  A 281 (-3.2A)
None
 1.22A 5nwuA-1ak0A:
0.0		 5nwuA-1ak0A:
8.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3M_A_ADNA502_1
(-)		 1ak0 P1 NUCLEASE
(Penicillium
citrinum) 		5 / 12 ASP A 153
ASP A  45
HIS A 149
GLY A 119
HIS A 116
 ZN  A 272 ( 2.1A)
ZN  A 271 (-3.2A)
THS  A 295 ( 3.4A)
None
ZN  A 271 (-3.5A)
 1.39A 6f3mA-1ak0A:
0.0		 6f3mA-1ak0A:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3M_B_ADNB502_1
(-)		 1ak0 P1 NUCLEASE
(Penicillium
citrinum) 		5 / 12 ASP A 153
ASP A  45
HIS A 149
GLY A 119
HIS A 116
 ZN  A 272 ( 2.1A)
ZN  A 271 (-3.2A)
THS  A 295 ( 3.4A)
None
ZN  A 271 (-3.5A)
 1.39A 6f3mB-1ak0A:
0.0		 6f3mB-1ak0A:
22.62