SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ak2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AKD_A_CAMA420_0
(CYTOCHROME P450CAM)		 1ak2 ADENYLATE KINASE
ISOENZYME-2
(Bos
taurus) 		5 / 11 THR A 105
GLY A 101
THR A  47
VAL A  80
ASP A  77
 None
 1.27A 1akdA-1ak2A:
undetectable		 1akdA-1ak2A:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SH9_B_RITB301_1
(POL POLYPROTEIN)		 1ak2 ADENYLATE KINASE
ISOENZYME-2
(Bos
taurus) 		5 / 8 ASP A 179
ILE A 140
ILE A 137
ILE A 186
PRO A  25
 None
None
None
None
SO4  A 301 ( 4.8A)
 1.20A 1sh9A-1ak2A:
0.0		 1sh9A-1ak2A:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7Q_A_ZMRA601_2
(NEURAMINIDASE)		 1ak2 ADENYLATE KINASE
ISOENZYME-2
(Bos
taurus) 		3 / 3 ARG A 143
ARG A 139
ILE A 145
 None
 0.90A 4b7qA-1ak2A:
undetectable		 4b7qA-1ak2A:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RN6_A_15UA301_1
(THROMBIN HEAVY CHAIN)		 1ak2 ADENYLATE KINASE
ISOENZYME-2
(Bos
taurus) 		5 / 10 HIS A 208
TYR A 202
ALA A 213
ALA A 210
GLY A  23
 None
 1.24A 4rn6A-1ak2A:
0.0		 4rn6A-1ak2A:
25.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JH7_D_6K9D502_0
(TUBULIN BETA-2B
CHAIN)		 1ak2 ADENYLATE KINASE
ISOENZYME-2
(Bos
taurus) 		5 / 11 VAL A 126
SER A 125
ASP A 124
PRO A 103
LEU A  22
 None
 1.09A 5jh7D-1ak2A:
3.3		 5jh7D-1ak2A:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JNA_C_TORC302_1
(CARBONIC ANHYDRASE 4)		 1ak2 ADENYLATE KINASE
ISOENZYME-2
(Bos
taurus) 		5 / 11 SER A 130
HIS A 208
VAL A 126
LEU A 198
THR A 195
 None
 1.31A 5jnaC-1ak2A:
undetectable		 5jnaC-1ak2A:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWO_A_SREA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 1ak2 ADENYLATE KINASE
ISOENZYME-2
(Bos
taurus) 		5 / 9 ALA A 210
ILE A 211
GLY A  28
PHE A 129
SER A 214
 None
None
SO4  A 301 (-3.4A)
None
None
 1.28A 6awoA-1ak2A:
0.0		 6awoA-1ak2A:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWQ_A_SREA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 1ak2 ADENYLATE KINASE
ISOENZYME-2
(Bos
taurus) 		5 / 9 ALA A 210
ILE A 211
GLY A  28
PHE A 129
SER A 214
 None
None
SO4  A 301 (-3.4A)
None
None
 1.29A 6awqA-1ak2A:
undetectable		 6awqA-1ak2A:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_C_RFPC502_1
(RIFAMPIN
MONOOXYGENASE)		 1ak2 ADENYLATE KINASE
ISOENZYME-2
(Bos
taurus) 		5 / 12 VAL A  20
VAL A 126
MET A 116
ARG A 119
GLY A  16
 None
 1.17A 6brdC-1ak2A:
undetectable		 6brdC-1ak2A:
18.45