SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ak6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF3_A_SAMA301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 1ak6 DESTRIN
(Homo
sapiens;
Sus
scrofa) 		5 / 12 GLY A   4
ALA A   2
ALA A 118
ALA A 123
VAL A   5
 None
 1.19A 4df3A-1ak6A:
undetectable		 4df3A-1ak6A:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF3_B_SAMB301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 1ak6 DESTRIN
(Homo
sapiens;
Sus
scrofa) 		5 / 12 GLY A   4
ALA A   2
ALA A 118
ALA A 123
VAL A   5
 None
 1.23A 4df3B-1ak6A:
undetectable		 4df3B-1ak6A:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_C_29SC601_2
(ESTROGEN RECEPTOR)		 1ak6 DESTRIN
(Homo
sapiens;
Sus
scrofa) 		4 / 6 LEU A 143
ILE A  55
HIS A  70
PRO A 164
 None
 1.08A 4xi3C-1ak6A:
undetectable		 4xi3C-1ak6A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C8T_D_SAMD605_0
(GUANINE-N7
METHYLTRANSFERASE)		 1ak6 DESTRIN
(Homo
sapiens;
Sus
scrofa) 		5 / 10 ASP A 142
ALA A 137
GLN A 136
PHE A 102
CYH A 147
 None
 1.48A 5c8tD-1ak6A:
0.0		 5c8tD-1ak6A:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z12_B_9CRB501_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1ak6 DESTRIN
(Homo
sapiens;
Sus
scrofa) 		3 / 3 GLN A 136
ILE A  55
HIS A  70
 None
 0.71A 5z12B-1ak6A:
undetectable		 5z12B-1ak6A:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 1ak6 DESTRIN
(Homo
sapiens;
Sus
scrofa) 		3 / 3 LYS A 112
LEU A 108
ASP A  79
 None
 0.87A 5zv2A-1ak6A:
undetectable		 5zv2A-1ak6A:
19.88