SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1akc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_A_CFXA1001_2
(BETA-LACTAMASE
CTX-M-9)		 1akc ASPARTATE
AMINOTRANSFERASE
(Gallus
gallus) 		4 / 5 TYR A 256
PRO A 299
THR A 271
SER A 111
 None
 1.47A 1ymxA-1akcA:
0.0		 1ymxA-1akcA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZX_A_TRPA602_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1akc ASPARTATE
AMINOTRANSFERASE
(Gallus
gallus) 		4 / 8 LEU A 310
ILE A 309
GLU A 322
ILE A 233
 None
 0.91A 2azxA-1akcA:
undetectable		 2azxA-1akcA:
24.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FL5_F_RBFF204_1
(IMMUNOGLOBULIN IGG1
LAMBDA LIGHT CHAIN
IMMUNOGLOBULIN IGG1
HEAVY CHAIN)		 1akc ASPARTATE
AMINOTRANSFERASE
(Gallus
gallus) 		4 / 8 TYR A 399
ARG A 372
GLU A 376
PHE A 377
 None
 1.06A 2fl5E-1akcA:
undetectable
2fl5F-1akcA:
undetectable		 2fl5E-1akcA:
19.35
2fl5F-1akcA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_C_SAMC300_1
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 1akc ASPARTATE
AMINOTRANSFERASE
(Gallus
gallus) 		4 / 4 SER A 111
GLY A 268
HIS A 189
ASP A 199
 None
None
PPE  A 411 ( 4.6A)
None
 1.29A 2oxtC-1akcA:
2.5		 2oxtC-1akcA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_A_ZMRA1776_2
(NEURAMINIDASE A)		 1akc ASPARTATE
AMINOTRANSFERASE
(Gallus
gallus) 		4 / 6 ASP A 249
ILE A 244
LEU A  88
GLU A  93
 None
 1.08A 2ya7A-1akcA:
0.0		 2ya7A-1akcA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_B_ZMRB1776_2
(NEURAMINIDASE A)		 1akc ASPARTATE
AMINOTRANSFERASE
(Gallus
gallus) 		4 / 6 ASP A 249
ILE A 244
LEU A  88
GLU A  93
 None
 1.05A 2ya7B-1akcA:
0.0		 2ya7B-1akcA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK3_A_0LIA1_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 1akc ASPARTATE
AMINOTRANSFERASE
(Gallus
gallus) 		4 / 7 LEU A 187
TYR A 220
ILE A 248
MET A 223
 None
 1.30A 3ik3A-1akcA:
undetectable		 3ik3A-1akcA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK3_A_0LIA1_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 1akc ASPARTATE
AMINOTRANSFERASE
(Gallus
gallus) 		4 / 7 LEU A 187
TYR A 220
MET A 223
ARG A 275
 None
 1.10A 3ik3A-1akcA:
undetectable		 3ik3A-1akcA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK3_B_0LIB2_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 1akc ASPARTATE
AMINOTRANSFERASE
(Gallus
gallus) 		4 / 7 LEU A 187
TYR A 220
ILE A 248
MET A 223
 None
 1.29A 3ik3B-1akcA:
undetectable		 3ik3B-1akcA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK3_B_0LIB2_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 1akc ASPARTATE
AMINOTRANSFERASE
(Gallus
gallus) 		4 / 7 LEU A 187
TYR A 220
MET A 223
ARG A 275
 None
 1.08A 3ik3B-1akcA:
undetectable		 3ik3B-1akcA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KKZ_B_SAMB302_0
(UNCHARACTERIZED
PROTEIN Q5LES9)		 1akc ASPARTATE
AMINOTRANSFERASE
(Gallus
gallus) 		5 / 12 ARG A 386
GLY A  36
LEU A 337
SER A 332
ALA A 390
 PPE  A 411 ( 2.7A)
None
None
None
None
 1.08A 3kkzB-1akcA:
2.9		 3kkzB-1akcA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_C_ACTC4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 1akc ASPARTATE
AMINOTRANSFERASE
(Gallus
gallus) 		4 / 4 GLY A  38
GLY A  36
THR A  21
LEU A  18
 PPE  A 411 ( 3.8A)
None
None
None
 0.89A 3si7C-1akcA:
1.1
3si7D-1akcA:
1.0		 3si7C-1akcA:
22.93
3si7D-1akcA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SO9_A_017A100_1
(HIV-1 PROTEASE)		 1akc ASPARTATE
AMINOTRANSFERASE
(Gallus
gallus) 		4 / 8 GLY A 302
ALA A 303
GLY A 105
ILE A 106
 None
 0.51A 3so9A-1akcA:
undetectable		 3so9A-1akcA:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_A_RTZA2_1
(CYTOCHROME P450 2D6)		 1akc ASPARTATE
AMINOTRANSFERASE
(Gallus
gallus) 		5 / 11 LEU A  86
SER A  92
GLU A  85
LEU A 252
THR A 102
 None
 1.31A 3tbgA-1akcA:
undetectable		 3tbgA-1akcA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OR0_A_NPSA602_1
(SERUM ALBUMIN)		 1akc ASPARTATE
AMINOTRANSFERASE
(Gallus
gallus) 		5 / 9 ALA A 190
ALA A 239
LEU A 208
LEU A 252
VAL A 250
 None
 1.13A 4or0A-1akcA:
0.0		 4or0A-1akcA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OR0_B_NPSB602_1
(SERUM ALBUMIN)		 1akc ASPARTATE
AMINOTRANSFERASE
(Gallus
gallus) 		5 / 9 ALA A 190
ALA A 239
LEU A 208
LEU A 252
VAL A 250
 None
 1.14A 4or0B-1akcA:
0.0		 4or0B-1akcA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PCL_B_SAMB301_0
(O-METHYLTRANSFERASE
FAMILY PROTEIN)		 1akc ASPARTATE
AMINOTRANSFERASE
(Gallus
gallus) 		5 / 12 GLU A 265
GLY A 302
ALA A 306
ALA A 267
TYR A 256
 None
 1.18A 4pclB-1akcA:
3.4		 4pclB-1akcA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YVP_A_GBMA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C1)		 1akc ASPARTATE
AMINOTRANSFERASE
(Gallus
gallus) 		5 / 11 LEU A 341
TRP A 350
ILE A 353
LEU A 373
LEU A 365
 None
 1.35A 4yvpA-1akcA:
undetectable		 4yvpA-1akcA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_A_8LXA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1akc ASPARTATE
AMINOTRANSFERASE
(Gallus
gallus) 		5 / 12 LEU A 400
PHE A 360
GLY A  36
TYR A 263
HIS A 258
 None
None
None
None
PPE  A 411 (-4.9A)
 1.26A 5y2tA-1akcA:
undetectable		 5y2tA-1akcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A7P_B_9SCB601_0
(SERUM ALBUMIN)		 1akc ASPARTATE
AMINOTRANSFERASE
(Gallus
gallus) 		5 / 12 VAL A 251
VAL A 103
LEU A 287
PHE A 118
LEU A 119
 None
 1.39A 6a7pB-1akcA:
undetectable		 6a7pB-1akcA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_C_AQ4C602_1
(CYTOCHROME P450 1A1)		 1akc ASPARTATE
AMINOTRANSFERASE
(Gallus
gallus) 		3 / 3 SER A 253
SER A 111
ALA A 257
 None
None
PPE  A 411 ( 3.8A)
 0.68A 6dwnC-1akcA:
0.0		 6dwnC-1akcA:
13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECT_A_SAMA1300_0
(STIE PROTEIN)		 1akc ASPARTATE
AMINOTRANSFERASE
(Gallus
gallus) 		5 / 12 GLY A 385
GLY A 364
ILE A 387
VAL A 370
LEU A 373
 None
 0.93A 6ectA-1akcA:
undetectable		 6ectA-1akcA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECX_A_SAMA1301_0
(STIE PROTEIN)		 1akc ASPARTATE
AMINOTRANSFERASE
(Gallus
gallus) 		5 / 12 GLY A 385
GLY A 364
ILE A 387
VAL A 370
LEU A 373
 None
 0.93A 6ecxA-1akcA:
3.4		 6ecxA-1akcA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HCX_A_ZMRA519_1
(NEURAMINIDASE)		 1akc ASPARTATE
AMINOTRANSFERASE
(Gallus
gallus) 		3 / 3 TRP A 319
ILE A 233
GLU A  85
 None
 0.83A 6hcxA-1akcA:
undetectable		 6hcxA-1akcA:
12.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_H_PCFH604_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 8
CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL)		 1akc ASPARTATE
AMINOTRANSFERASE
(Gallus
gallus) 		5 / 8 GLY A 261
VAL A 323
GLY A 268
SER A 255
ALA A 224
 None
None
None
PPE  A 411 ( 3.0A)
PPE  A 411 ( 3.6A)
 1.25A 6hu9H-1akcA:
0.0
6hu9e-1akcA:
0.4		 6hu9H-1akcA:
11.84
6hu9e-1akcA:
15.56