SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1akm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMC_B_SAMB105_0
(MET REPRESSOR)		 1akm ORNITHINE
TRANSCARBAMYLASE
(Escherichia
coli) 		5 / 10 GLU A 174
LEU A 197
GLU A 200
ALA A 177
GLY A 180
 None
 1.25A 1cmcA-1akmA:
undetectable
1cmcB-1akmA:
undetectable		 1cmcA-1akmA:
15.32
1cmcB-1akmA:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_C_SAMC2199_0
(PROTEIN (METHIONINE
REPRESSOR))		 1akm ORNITHINE
TRANSCARBAMYLASE
(Escherichia
coli) 		5 / 12 GLY A 180
GLU A 174
LEU A 197
GLU A 200
LEU A 204
 None
 1.25A 1mj2C-1akmA:
undetectable
1mj2D-1akmA:
undetectable		 1mj2C-1akmA:
15.02
1mj2D-1akmA:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_C_SAMC200_0
(METHIONINE REPRESSOR)		 1akm ORNITHINE
TRANSCARBAMYLASE
(Escherichia
coli) 		5 / 12 GLY A 180
GLU A 174
LEU A 197
GLU A 200
LEU A 204
 None
 1.26A 1mjoC-1akmA:
undetectable
1mjoD-1akmA:
undetectable		 1mjoC-1akmA:
15.02
1mjoD-1akmA:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_B_SAMB200_0
(METHIONINE REPRESSOR)		 1akm ORNITHINE
TRANSCARBAMYLASE
(Escherichia
coli) 		5 / 11 GLY A 180
GLU A 174
LEU A 197
GLU A 200
LEU A 204
 None
 1.19A 1mjqA-1akmA:
undetectable
1mjqB-1akmA:
undetectable		 1mjqA-1akmA:
15.02
1mjqB-1akmA:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_H_SAMH200_0
(METHIONINE REPRESSOR)		 1akm ORNITHINE
TRANSCARBAMYLASE
(Escherichia
coli) 		5 / 10 GLY A 180
GLU A 174
LEU A 197
GLU A 200
LEU A 204
 None
 1.20A 1mjqG-1akmA:
undetectable
1mjqH-1akmA:
undetectable		 1mjqG-1akmA:
15.02
1mjqH-1akmA:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACL_C_REAC503_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1akm ORNITHINE
TRANSCARBAMYLASE
(Escherichia
coli) 		5 / 10 ALA A  65
ALA A  66
GLN A  69
ASN A  46
ILE A 103
 None
 1.02A 2aclC-1akmA:
undetectable		 2aclC-1akmA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACL_E_REAE504_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1akm ORNITHINE
TRANSCARBAMYLASE
(Escherichia
coli) 		5 / 11 ALA A  65
ALA A  66
GLN A  69
ASN A  46
ILE A 103
 None
 1.12A 2aclE-1akmA:
undetectable		 2aclE-1akmA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DU8_A_BEZA352_0
(D-AMINO-ACID OXIDASE)		 1akm ORNITHINE
TRANSCARBAMYLASE
(Escherichia
coli) 		4 / 6 LEU A 116
TYR A 105
ILE A  50
GLY A  84
 None
 0.86A 2du8A-1akmA:
4.3		 2du8A-1akmA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DU8_B_BEZB1352_0
(D-AMINO-ACID OXIDASE)		 1akm ORNITHINE
TRANSCARBAMYLASE
(Escherichia
coli) 		4 / 6 LEU A 116
TYR A 105
ILE A  50
GLY A  84
 None
 0.84A 2du8B-1akmA:
4.3		 2du8B-1akmA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NMZ_B_ROCB401_2
(PROTEASE)		 1akm ORNITHINE
TRANSCARBAMYLASE
(Escherichia
coli) 		3 / 3 ARG A 246
VAL A 255
THR A 230
 None
 0.76A 2nmzA-1akmA:
0.0		 2nmzA-1akmA:
12.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNK_A_ROCA401_2
(PROTEASE)		 1akm ORNITHINE
TRANSCARBAMYLASE
(Escherichia
coli) 		3 / 3 ARG A 246
VAL A 255
THR A 230
 None
 0.71A 2nnkA-1akmA:
0.0		 2nnkA-1akmA:
12.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q63_A_1UNA1001_2
(PROTEASE RETROPEPSIN)		 1akm ORNITHINE
TRANSCARBAMYLASE
(Escherichia
coli) 		3 / 3 ARG A 246
ASN A 256
THR A 230
 None
 0.85A 2q63A-1akmA:
0.0		 2q63A-1akmA:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VUF_A_FUAA2002_1
(SERUM ALBUMIN)		 1akm ORNITHINE
TRANSCARBAMYLASE
(Escherichia
coli) 		4 / 9 ILE A 228
ALA A 219
VAL A 222
GLU A 223
 None
 0.63A 2vufA-1akmA:
0.0		 2vufA-1akmA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E00_A_9CRA7223_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1akm ORNITHINE
TRANSCARBAMYLASE
(Escherichia
coli) 		5 / 12 ALA A  65
ALA A  66
GLN A  69
ASN A  46
ILE A 103
 None
 0.99A 3e00A-1akmA:
undetectable		 3e00A-1akmA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_B_ROCB201_2
(HIV-1 PROTEASE)		 1akm ORNITHINE
TRANSCARBAMYLASE
(Escherichia
coli) 		3 / 3 ARG A 246
VAL A 255
THR A 230
 None
 0.70A 3k4vA-1akmA:
0.0		 3k4vA-1akmA:
11.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_D_ROCD201_4
(HIV-1 PROTEASE)		 1akm ORNITHINE
TRANSCARBAMYLASE
(Escherichia
coli) 		3 / 3 ARG A 246
VAL A 255
THR A 230
 None
 0.70A 3k4vD-1akmA:
0.0		 3k4vD-1akmA:
11.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MYU_B_VIBB500_1
(HIGH AFFINITY
TRANSPORT SYSTEM
PROTEIN P37)		 1akm ORNITHINE
TRANSCARBAMYLASE
(Escherichia
coli) 		5 / 10 TYR A 229
ASP A 140
TYR A 160
ASP A 231
GLY A 169
 None
 1.49A 3myuB-1akmA:
0.8		 3myuB-1akmA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDT_A_ROCA101_2
(PROTEASE)		 1akm ORNITHINE
TRANSCARBAMYLASE
(Escherichia
coli) 		3 / 3 ARG A 246
VAL A 255
THR A 230
 None
 0.72A 3ndtA-1akmA:
undetectable		 3ndtA-1akmA:
11.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDU_D_ROCD100_3
(PROTEASE)		 1akm ORNITHINE
TRANSCARBAMYLASE
(Escherichia
coli) 		3 / 3 ARG A 246
VAL A 255
THR A 230
 None
 0.75A 3nduD-1akmA:
0.0		 3nduD-1akmA:
11.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWR_A_ROCA401_2
(PROTEASE)		 1akm ORNITHINE
TRANSCARBAMYLASE
(Escherichia
coli) 		3 / 3 ARG A 246
VAL A 255
THR A 230
 None
 0.81A 3pwrA-1akmA:
0.0		 3pwrA-1akmA:
11.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TL9_A_ROCA401_2
(PROTEASE)		 1akm ORNITHINE
TRANSCARBAMYLASE
(Escherichia
coli) 		3 / 3 ARG A 246
VAL A 255
THR A 230
 None
 0.74A 3tl9A-1akmA:
0.0		 3tl9A-1akmA:
11.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_E_ZPCE1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 1akm ORNITHINE
TRANSCARBAMYLASE
(Escherichia
coli) 		4 / 6 GLU A  18
HIS A   5
VAL A 124
PHE A  14
 None
 1.22A 4a97E-1akmA:
0.0		 4a97E-1akmA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYR_B_RITB301_2
(HIV-1 PROTEASE)		 1akm ORNITHINE
TRANSCARBAMYLASE
(Escherichia
coli) 		4 / 8 ARG A 106
ALA A  65
ASP A  68
THR A 135
 None
 0.76A 4eyrB-1akmA:
undetectable		 4eyrB-1akmA:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXE_B_ESTB1000_1
(ESTROGEN RECEPTOR)		 1akm ORNITHINE
TRANSCARBAMYLASE
(Escherichia
coli) 		5 / 10 LEU A  19
ALA A 175
LEU A 137
LEU A 138
LEU A  12
 None
 1.43A 5dxeB-1akmA:
undetectable		 5dxeB-1akmA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESE_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1akm ORNITHINE
TRANSCARBAMYLASE
(Escherichia
coli) 		4 / 8 LEU A 158
ILE A 212
GLY A 169
LEU A 137
 None
 0.75A 5eseA-1akmA:
0.1		 5eseA-1akmA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_A_1N1A501_1
(PROTEIN-TYROSINE
KINASE 6)		 1akm ORNITHINE
TRANSCARBAMYLASE
(Escherichia
coli) 		6 / 12 LEU A 173
ALA A 176
LEU A 141
THR A 179
LEU A 183
LEU A 137
 None
 1.32A 5h2uA-1akmA:
undetectable		 5h2uA-1akmA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOX_A_RFPA502_1
(PENTACHLOROPHENOL
4-MONOOXYGENASE)		 1akm ORNITHINE
TRANSCARBAMYLASE
(Escherichia
coli) 		6 / 12 GLY A 285
PHE A 292
GLY A 162
PHE A 270
THR A 301
GLY A 297
 None
 1.42A 5koxA-1akmA:
undetectable		 5koxA-1akmA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDH_C_DAHC60_1
(PUTATIVE CYTOCHROME
C)		 1akm ORNITHINE
TRANSCARBAMYLASE
(Escherichia
coli) 		4 / 6 GLN A 110
MET A 172
ASN A 130
LEU A 137
 None
 1.14A 5xdhA-1akmA:
0.0
5xdhC-1akmA:
0.0		 5xdhA-1akmA:
12.00
5xdhC-1akmA:
12.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_F_EY4F500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 1akm ORNITHINE
TRANSCARBAMYLASE
(Escherichia
coli) 		5 / 7 ALA A 117
THR A 115
ILE A  50
GLN A 104
VAL A 124
 None
 1.45A 6cduF-1akmA:
undetectable
6cduJ-1akmA:
0.0		 6cduF-1akmA:
20.58
6cduJ-1akmA:
20.58