SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ako'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L2I_B_CCSB417_0
(ESTROGEN RECEPTOR)		 1ako EXONUCLEASE III
(Escherichia
coli) 		4 / 6 PRO A 261
PHE A   6
GLN A  17
VAL A  22
 None
 1.45A 1l2iB-1akoA:
undetectable		 1l2iB-1akoA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E1Q_D_SALD5006_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 1ako EXONUCLEASE III
(Escherichia
coli) 		4 / 5 PHE A 266
THR A 198
LEU A 195
ALA A 238
 None
 1.14A 2e1qD-1akoA:
0.0		 2e1qD-1akoA:
11.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NV4_A_ACTA148_0
(UPF0066 PROTEIN
AF_0241)		 1ako EXONUCLEASE III
(Escherichia
coli) 		3 / 3 VAL A  22
GLU A  19
GLU A  23
 None
 0.79A 2nv4A-1akoA:
0.0		 2nv4A-1akoA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_B_DIFB1374_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 1ako EXONUCLEASE III
(Escherichia
coli) 		4 / 6 MET A 152
PRO A 111
ILE A 154
LEU A 190
 None
 1.07A 2wekB-1akoA:
undetectable		 2wekB-1akoA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A35_A_RBFA191_1
(LUMAZINE PROTEIN)		 1ako EXONUCLEASE III
(Escherichia
coli) 		5 / 12 VAL A  29
LEU A  68
THR A  69
THR A  35
ILE A   8
 None
 1.15A 3a35A-1akoA:
undetectable		 3a35A-1akoA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A35_B_RBFB191_1
(LUMAZINE PROTEIN)		 1ako EXONUCLEASE III
(Escherichia
coli) 		5 / 12 VAL A  29
LEU A  68
THR A  69
THR A  35
ILE A   8
 None
 1.17A 3a35B-1akoA:
undetectable		 3a35B-1akoA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A3B_A_RBFA191_1
(LUMAZINE PROTEIN)		 1ako EXONUCLEASE III
(Escherichia
coli) 		5 / 12 VAL A  29
LEU A  68
THR A  69
THR A  35
ILE A   8
 None
 1.13A 3a3bA-1akoA:
undetectable		 3a3bA-1akoA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_C_SHHC301_1
(HISTONE DEACETYLASE
7A)		 1ako EXONUCLEASE III
(Escherichia
coli) 		4 / 6 ASP A 214
ASP A 229
HIS A 259
ASP A 151
 None
 1.12A 3c0zC-1akoA:
undetectable		 3c0zC-1akoA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_B_DXCB1473_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 1ako EXONUCLEASE III
(Escherichia
coli) 		4 / 8 ILE A 246
GLY A 245
PHE A 199
ARG A 184
 None
 0.90A 4acbB-1akoA:
undetectable
4acbC-1akoA:
undetectable		 4acbB-1akoA:
21.62
4acbC-1akoA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_A_NCTA501_1
(CYTOCHROME P450 2A6)		 1ako EXONUCLEASE III
(Escherichia
coli) 		5 / 7 PHE A 110
ASN A   7
GLY A 150
ILE A  91
PHE A 128
 None
 1.41A 4ejjA-1akoA:
0.0		 4ejjA-1akoA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LF7_A_PARA1817_1
(16S RRNA
RIBOSOMAL PROTEIN S9
RIBOSOMAL PROTEIN
S10)		 1ako EXONUCLEASE III
(Escherichia
coli) 		3 / 3 TYR A 215
ARG A  14
SER A 257
 None
 0.97A 4lf7I-1akoA:
0.0
4lf7J-1akoA:
0.0		 4lf7I-1akoA:
21.07
4lf7J-1akoA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LF8_A_PARA1817_1
(16S RRNA
RIBOSOMAL PROTEIN S9
RIBOSOMAL PROTEIN
S10)		 1ako EXONUCLEASE III
(Escherichia
coli) 		3 / 3 TYR A 215
ARG A  14
SER A 257
 None
 0.97A 4lf8I-1akoA:
0.0
4lf8J-1akoA:
0.0		 4lf8I-1akoA:
21.07
4lf8J-1akoA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0S_A_PX9A201_0
(BETA-LACTOGLOBULIN)		 1ako EXONUCLEASE III
(Escherichia
coli) 		5 / 12 LEU A  32
LEU A  11
ILE A   8
VAL A  47
LEU A  68
 None
 0.97A 4y0sA-1akoA:
0.0		 4y0sA-1akoA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_B_P06B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1ako EXONUCLEASE III
(Escherichia
coli) 		3 / 3 PHE A 199
ILE A 246
ASP A 151
 None
 0.73A 5cswB-1akoA:
undetectable		 5cswB-1akoA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_A_SAMA301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 1ako EXONUCLEASE III
(Escherichia
coli) 		5 / 12 GLY A 150
LEU A  32
ILE A 148
LEU A 232
GLY A  64
 None
 1.08A 5d4uA-1akoA:
undetectable		 5d4uA-1akoA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_B_SAMB301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 1ako EXONUCLEASE III
(Escherichia
coli) 		5 / 12 GLY A 150
LEU A  32
ILE A 148
LEU A 232
GLY A  64
 None
 1.10A 5d4uB-1akoA:
undetectable		 5d4uB-1akoA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_A_RFPA502_1
(RIFAMPIN
MONOOXYGENASE)		 1ako EXONUCLEASE III
(Escherichia
coli) 		5 / 12 LEU A 147
MET A 187
PHE A 266
THR A 244
GLY A 245
 None
 0.91A 6brdA-1akoA:
undetectable		 6brdA-1akoA:
13.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HZP_A_FVTA501_0
(PEPTIDE ABC
TRANSPORTER PERMEASE)		 1ako EXONUCLEASE III
(Escherichia
coli) 		4 / 8 VAL A  54
GLN A  33
ASN A 107
ILE A  92
 None
 0.88A 6hzpA-1akoA:
undetectable		 6hzpA-1akoA:
18.65