SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1al3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W0G_A_MYTA1499_1
(CYTOCHROME P450 3A4)		 1al3 CYS REGULON
TRANSCRIPTIONAL
ACTIVATOR CYSB
(Klebsiella
aerogenes) 		4 / 6 ILE A 134
ALA A 148
THR A 270
ALA A 107
 None
SO4  A 500 ( 3.9A)
SO4  A 500 ( 4.9A)
None
 0.92A 1w0gA-1al3A:
undetectable		 1w0gA-1al3A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_A_CHDA501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1al3 CYS REGULON
TRANSCRIPTIONAL
ACTIVATOR CYSB
(Klebsiella
aerogenes) 		5 / 12 LEU A 124
LEU A  95
ILE A 112
LEU A 161
VAL A 159
 None
 1.01A 2pnjA-1al3A:
undetectable		 2pnjA-1al3A:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VH3_B_DAHB2_1
(RANASMURFIN)		 1al3 CYS REGULON
TRANSCRIPTIONAL
ACTIVATOR CYSB
(Klebsiella
aerogenes) 		4 / 8 SER A 268
GLY A 203
SER A 245
ALA A 244
 None
 0.78A 2vh3B-1al3A:
0.0		 2vh3B-1al3A:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_1
(CYTOCHROME P450 2R1)		 1al3 CYS REGULON
TRANSCRIPTIONAL
ACTIVATOR CYSB
(Klebsiella
aerogenes) 		5 / 12 VAL A  97
ALA A 143
VAL A 122
ILE A 272
THR A  99
 None
 1.09A 3czhA-1al3A:
0.0		 3czhA-1al3A:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DL9_A_V2HA602_0
(CYTOCHROME P450 2R1)		 1al3 CYS REGULON
TRANSCRIPTIONAL
ACTIVATOR CYSB
(Klebsiella
aerogenes) 		5 / 12 VAL A  97
ALA A 143
VAL A 122
ILE A 272
THR A  99
 None
 1.09A 3dl9A-1al3A:
0.0		 3dl9A-1al3A:
22.97