SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1al8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_G_TRPG81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 1al8 GLYCOLATE OXIDASE
(Spinacia
oleracea) 		4 / 7 GLY A 231
HIS A 254
THR A 265
ILE A 250
 None
FMN  A 360 ( 3.9A)
None
None
 0.94A 1gtnF-1al8A:
undetectable
1gtnG-1al8A:
undetectable		 1gtnF-1al8A:
13.54
1gtnG-1al8A:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_K_TRPK81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 1al8 GLYCOLATE OXIDASE
(Spinacia
oleracea) 		4 / 7 GLY A 231
HIS A 254
THR A 265
ILE A 250
 None
FMN  A 360 ( 3.9A)
None
None
 0.95A 1gtnJ-1al8A:
undetectable
1gtnK-1al8A:
undetectable		 1gtnJ-1al8A:
13.54
1gtnK-1al8A:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_A_CHDA1503_0
(FERROCHELATASE)		 1al8 GLYCOLATE OXIDASE
(Spinacia
oleracea) 		3 / 3 LEU A 174
PRO A 175
LEU A 178
 None
 0.47A 1hrkA-1al8A:
undetectable		 1hrkA-1al8A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JTX_A_CVIA200_0
(HYPOTHETICAL
TRANSCRIPTIONAL
REGULATOR IN QACA
5'REGION)		 1al8 GLYCOLATE OXIDASE
(Spinacia
oleracea) 		5 / 12 ILE A 307
TYR A   9
ILE A  12
ALA A 317
THR A  92
 None
 1.19A 1jtxA-1al8A:
undetectable		 1jtxA-1al8A:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXG_B_IBPB2002_1
(SERUM ALBUMIN)		 1al8 GLYCOLATE OXIDASE
(Spinacia
oleracea) 		5 / 10 ALA A 246
ALA A 247
LEU A  65
LEU A 228
ALA A 151
 None
 1.01A 2bxgB-1al8A:
undetectable		 2bxgB-1al8A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C6G_B_VD3B700_1
(CYTOCHROME P450 2R1)		 1al8 GLYCOLATE OXIDASE
(Spinacia
oleracea) 		5 / 12 MET A  60
ALA A  99
VAL A 294
GLY A 304
THR A 104
 None
 1.09A 3c6gB-1al8A:
0.0		 3c6gB-1al8A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FAL_A_REAA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1al8 GLYCOLATE OXIDASE
(Spinacia
oleracea) 		5 / 10 ILE A 227
ALA A 246
ALA A 241
VAL A 141
ILE A 222
 None
 1.12A 3falA-1al8A:
undetectable		 3falA-1al8A:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWQ_C_VIAC901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
CATALYTIC DOMAIN,
CONE CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
SUBUNIT ALPHA
CHIMERA)		 1al8 GLYCOLATE OXIDASE
(Spinacia
oleracea) 		4 / 7 TYR A 131
LEU A 154
PHE A 126
VAL A 113
 None
 1.06A 3jwqC-1al8A:
undetectable		 3jwqC-1al8A:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_A_THHA642_1
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 1al8 GLYCOLATE OXIDASE
(Spinacia
oleracea) 		3 / 3 ASN A  38
ASP A 285
ARG A 209
 None
FMN  A 360 (-2.7A)
None
 0.82A 3k13A-1al8A:
7.3		 3k13A-1al8A:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LM8_B_VIBB223_1
(THIAMINE
PYROPHOSPHOKINASE)		 1al8 GLYCOLATE OXIDASE
(Spinacia
oleracea) 		4 / 7 TYR A 129
LEU A 211
LEU A 154
THR A 104
 DHP  A 361 ( 4.3A)
None
None
None
 1.04A 3lm8B-1al8A:
undetectable
3lm8D-1al8A:
undetectable		 3lm8B-1al8A:
20.89
3lm8D-1al8A:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3REM_A_SALA301_1
(SALICYLATE
BIOSYNTHESIS PROTEIN
PCHB)		 1al8 GLYCOLATE OXIDASE
(Spinacia
oleracea) 		4 / 8 VAL A 294
ARG A 290
VAL A   6
ILE A 307
 None
 1.02A 3remA-1al8A:
undetectable		 3remA-1al8A:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3REM_B_SALB301_1
(SALICYLATE
BIOSYNTHESIS PROTEIN
PCHB)		 1al8 GLYCOLATE OXIDASE
(Spinacia
oleracea) 		4 / 8 VAL A 294
ARG A 290
VAL A   6
ILE A 307
 None
 0.99A 3remB-1al8A:
undetectable		 3remB-1al8A:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1al8 GLYCOLATE OXIDASE
(Spinacia
oleracea) 		3 / 3 LEU A 174
PRO A 175
LEU A 178
 None
 0.42A 3w1wB-1al8A:
0.8		 3w1wB-1al8A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAT_B_BEZB1000_0
(BENZOATE-COENZYME A
LIGASE)		 1al8 GLYCOLATE OXIDASE
(Spinacia
oleracea) 		5 / 9 ALA A 302
ALA A 276
GLY A 278
ILE A 280
ILE A 249
 None
 1.07A 4eatB-1al8A:
undetectable		 4eatB-1al8A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYZ_A_CCSA109_0
(CELLULOSOME-RELATED
PROTEIN MODULE FROM
RUMINOCOCCUS
FLAVEFACIENS THAT
RESEMBLES
PAPAIN-LIKE CYSTEINE
PEPTIDASES)		 1al8 GLYCOLATE OXIDASE
(Spinacia
oleracea) 		4 / 8 VAL A 141
ILE A 152
SER A 224
ALA A 247
 None
 0.88A 4eyzA-1al8A:
0.0		 4eyzA-1al8A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYZ_B_CCSB109_0
(CELLULOSOME-RELATED
PROTEIN MODULE FROM
RUMINOCOCCUS
FLAVEFACIENS THAT
RESEMBLES
PAPAIN-LIKE CYSTEINE
PEPTIDASES)		 1al8 GLYCOLATE OXIDASE
(Spinacia
oleracea) 		4 / 8 VAL A 141
ILE A 152
SER A 224
ALA A 247
 None
 0.87A 4eyzB-1al8A:
0.0		 4eyzB-1al8A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_B_LOCB503_2
(TUBULIN BETA-2B
CHAIN)		 1al8 GLYCOLATE OXIDASE
(Spinacia
oleracea) 		5 / 12 LEU A 298
ALA A 297
MET A  74
THR A 101
ILE A  64
 None
 1.08A 4o2bB-1al8A:
2.7		 4o2bB-1al8A:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O4D_A_ACTA406_0
(INOSITOL
HEXAKISPHOSPHATE
KINASE)		 1al8 GLYCOLATE OXIDASE
(Spinacia
oleracea) 		4 / 7 ASP A 293
THR A 292
PHE A  42
SER A  43
 None
 1.30A 4o4dA-1al8A:
0.0		 4o4dA-1al8A:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OR0_A_NPSA602_1
(SERUM ALBUMIN)		 1al8 GLYCOLATE OXIDASE
(Spinacia
oleracea) 		5 / 9 ALA A  91
ALA A  93
SER A 314
LEU A 315
VAL A 311
 None
 1.20A 4or0A-1al8A:
undetectable		 4or0A-1al8A:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4POO_B_SAMB301_0
(PUTATIVE RNA
METHYLASE)		 1al8 GLYCOLATE OXIDASE
(Spinacia
oleracea) 		5 / 12 GLY A 286
ASN A  38
ASP A 293
ASP A 285
ILE A 250
 FMN  A 360 (-3.3A)
None
None
FMN  A 360 (-2.7A)
None
 1.29A 4pooB-1al8A:
undetectable		 4pooB-1al8A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1Y_B_LOCB502_1
(TUBULIN BETA CHAIN)		 1al8 GLYCOLATE OXIDASE
(Spinacia
oleracea) 		5 / 12 LEU A 298
ALA A 297
MET A  74
THR A 101
ILE A  64
 None
 1.10A 4x1yB-1al8A:
2.7		 4x1yB-1al8A:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_A_1N1A501_2
(PROTEIN-TYROSINE
KINASE 6)		 1al8 GLYCOLATE OXIDASE
(Spinacia
oleracea) 		3 / 3 ILE A  45
MET A 338
ASP A 293
 None
 0.83A 5h2uA-1al8A:
undetectable		 5h2uA-1al8A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 1al8 GLYCOLATE OXIDASE
(Spinacia
oleracea) 		5 / 12 MET A  74
ILE A 102
VAL A 305
ALA A 302
GLY A 278
 None
 1.06A 5igiA-1al8A:
0.0		 5igiA-1al8A:
25.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_B_PFLB510_1
(PROTON-GATED ION
CHANNEL)		 1al8 GLYCOLATE OXIDASE
(Spinacia
oleracea) 		4 / 6 ILE A 266
ALA A 297
LEU A 300
ILE A 354
 None
 0.71A 5mvmB-1al8A:
undetectable
5mvmC-1al8A:
0.0		 5mvmB-1al8A:
13.76
5mvmC-1al8A:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_D_ERMD1201_2
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 1al8 GLYCOLATE OXIDASE
(Spinacia
oleracea) 		4 / 6 LEU A  65
THR A 101
LEU A 228
GLU A 145
 None
 0.91A 5tudD-1al8A:
0.0		 5tudD-1al8A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_A_RITA602_2
(CYTOCHROME P450 3A5)		 1al8 GLYCOLATE OXIDASE
(Spinacia
oleracea) 		3 / 3 ARG A 142
PHE A 125
LEU A 128
 None
 0.81A 5veuA-1al8A:
0.0		 5veuA-1al8A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1804_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1al8 GLYCOLATE OXIDASE
(Spinacia
oleracea) 		5 / 8 GLY A 286
VAL A 294
ILE A 307
GLY A 308
ILE A  64
 FMN  A 360 (-3.3A)
None
None
FMN  A 360 (-3.5A)
None
 0.98A 5vkqB-1al8A:
0.0
5vkqC-1al8A:
0.0		 5vkqB-1al8A:
11.41
5vkqC-1al8A:
11.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1804_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1al8 GLYCOLATE OXIDASE
(Spinacia
oleracea) 		5 / 8 GLY A 286
VAL A 294
ILE A 307
GLY A 308
ILE A  69
 FMN  A 360 (-3.3A)
None
None
FMN  A 360 (-3.5A)
None
 1.14A 5vkqB-1al8A:
0.0
5vkqC-1al8A:
0.0		 5vkqB-1al8A:
11.41
5vkqC-1al8A:
11.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1804_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1al8 GLYCOLATE OXIDASE
(Spinacia
oleracea) 		5 / 8 GLY A 287
VAL A 294
ILE A 307
GLY A 308
ILE A  64
 FMN  A 360 (-3.8A)
None
None
FMN  A 360 (-3.5A)
None
 1.09A 5vkqB-1al8A:
0.0
5vkqC-1al8A:
0.0		 5vkqB-1al8A:
11.41
5vkqC-1al8A:
11.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1805_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1al8 GLYCOLATE OXIDASE
(Spinacia
oleracea) 		5 / 9 GLY A 286
VAL A 294
ILE A 307
GLY A 308
ILE A  64
 FMN  A 360 (-3.3A)
None
None
FMN  A 360 (-3.5A)
None
 0.96A 5vkqC-1al8A:
0.0
5vkqD-1al8A:
0.0		 5vkqC-1al8A:
11.41
5vkqD-1al8A:
11.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_A_SALA201_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 1al8 GLYCOLATE OXIDASE
(Spinacia
oleracea) 		4 / 5 VAL A 288
ARG A 289
PRO A 310
GLY A 308
 None
FMN  A 360 (-2.9A)
None
FMN  A 360 (-3.5A)
 0.94A 5x80A-1al8A:
0.0
5x80B-1al8A:
0.0		 5x80A-1al8A:
22.28
5x80B-1al8A:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_C_SALC201_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 1al8 GLYCOLATE OXIDASE
(Spinacia
oleracea) 		5 / 7 VAL A 288
ARG A 289
VAL A 326
PRO A 310
GLY A 308
 None
FMN  A 360 (-2.9A)
None
None
FMN  A 360 (-3.5A)
 1.19A 5x80C-1al8A:
undetectable
5x80D-1al8A:
0.0		 5x80C-1al8A:
22.28
5x80D-1al8A:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_D_SALD201_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 1al8 GLYCOLATE OXIDASE
(Spinacia
oleracea) 		4 / 5 PRO A 310
GLY A 308
VAL A 288
ARG A 289
 None
FMN  A 360 (-3.5A)
None
FMN  A 360 (-2.9A)
 0.97A 5x80C-1al8A:
undetectable
5x80D-1al8A:
0.0		 5x80C-1al8A:
22.28
5x80D-1al8A:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CLX_A_SAMA401_0
(O-METHYLTRANSFERASE)		 1al8 GLYCOLATE OXIDASE
(Spinacia
oleracea) 		5 / 12 ASP A 293
ALA A 302
GLY A 286
ARG A  39
VAL A 251
 None
None
FMN  A 360 (-3.3A)
None
None
 1.23A 6clxA-1al8A:
undetectable		 6clxA-1al8A:
23.98