SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1am2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FPQ_A_SAMA1699_0
(ISOLIQUIRITIGENIN
2'-O-METHYLTRANSFERA
SE)		 1am2 MXE GYRA INTEIN
(Mycobacterium
xenopi) 		5 / 10 GLY A  71
VAL A  61
ASP A 171
ALA A   0
ASN A  74
 None
 1.38A 1fpqA-1am2A:
undetectable		 1fpqA-1am2A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KGL_A_RTLA175_0
(CELLULAR
RETINOL-BINDING
PROTEIN TYPE I)		 1am2 MXE GYRA INTEIN
(Mycobacterium
xenopi) 		5 / 12 PHE A 189
LEU A  77
GLY A  71
ILE A   2
LEU A  50
 None
 1.19A 1kglA-1am2A:
undetectable		 1kglA-1am2A:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MCL_P_DHIP1_0
(IMMUNOGLOBULIN
LAMBDA DIMER MCG
(LIGHT CHAIN)
N-ACETYL-D-HIS-L-PRO
-OH)		 1am2 MXE GYRA INTEIN
(Mycobacterium
xenopi) 		4 / 5 TYR A 162
GLU A  65
PHE A 194
TYR A 102
 None
 1.26A 1mclA-1am2A:
0.0
1mclB-1am2A:
0.0
1mclP-1am2A:
undetectable		 1mclA-1am2A:
23.89
1mclB-1am2A:
23.89
1mclP-1am2A:
2.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJT_A_SAMA501_1
(N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE)		 1am2 MXE GYRA INTEIN
(Mycobacterium
xenopi) 		3 / 3 ARG A 160
ASP A 154
ASP A 148
 None
 0.81A 2ejtA-1am2A:
undetectable		 2ejtA-1am2A:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_B_SAMB530_0
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 1am2 MXE GYRA INTEIN
(Mycobacterium
xenopi) 		5 / 12 ILE A 105
ALA A 188
THR A 191
GLY A 193
THR A 184
 None
 1.07A 2y7hB-1am2A:
undetectable		 2y7hB-1am2A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_C_SAMC530_0
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 1am2 MXE GYRA INTEIN
(Mycobacterium
xenopi) 		5 / 12 ILE A 105
ALA A 188
THR A 191
GLY A 193
THR A 184
 None
 1.07A 2y7hC-1am2A:
undetectable		 2y7hC-1am2A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGO_A_PCFA1213_0
(WNT INHIBITORY
FACTOR 1)		 1am2 MXE GYRA INTEIN
(Mycobacterium
xenopi) 		6 / 12 ILE A 190
ILE A 105
PHE A 110
ILE A   2
VAL A  61
VAL A 166
 None
 1.49A 2ygoA-1am2A:
0.0		 2ygoA-1am2A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXV_D_MTXD2000_2
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 1am2 MXE GYRA INTEIN
(Mycobacterium
xenopi) 		3 / 3 LEU A  89
ARG A 107
ASN A  43
 None
 0.70A 3qxvD-1am2A:
undetectable		 3qxvD-1am2A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_D_29SD601_2
(ESTROGEN RECEPTOR)		 1am2 MXE GYRA INTEIN
(Mycobacterium
xenopi) 		3 / 3 LEU A  50
ASP A  48
ILE A   2
 None
 0.58A 4xi3D-1am2A:
0.0		 4xi3D-1am2A:
25.19