SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1amk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM9_A_9CRA201_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1amk TRIOSE PHOSPHATE
ISOMERASE
(Leishmania
mexicana) 		3 / 3 GLN A  52
ILE A 246
HIS A  31
 None
 0.66A 1fm9A-1amkA:
undetectable		 1fm9A-1amkA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K74_A_9CRA463_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1amk TRIOSE PHOSPHATE
ISOMERASE
(Leishmania
mexicana) 		3 / 3 GLN A  52
ILE A 246
HIS A  31
 None
 0.65A 1k74A-1amkA:
undetectable		 1k74A-1amkA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQE_A_DVAA6_0
(MINI-GRAMICIDIN A)		 1amk TRIOSE PHOSPHATE
ISOMERASE
(Leishmania
mexicana) 		3 / 3 ALA A  64
VAL A  41
TRP A  12
 None
 0.82A 1kqeA-1amkA:
undetectable
1kqeE-1amkA:
undetectable		 1kqeA-1amkA:
11.43
1kqeE-1amkA:
11.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQE_B_DVAB6_0
(MINI-GRAMICIDIN A)		 1amk TRIOSE PHOSPHATE
ISOMERASE
(Leishmania
mexicana) 		3 / 3 ALA A  64
VAL A  41
TRP A  12
 None
 0.82A 1kqeB-1amkA:
undetectable
1kqeD-1amkA:
undetectable		 1kqeB-1amkA:
11.43
1kqeD-1amkA:
11.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQE_D_DVAD6_0
(MINI-GRAMICIDIN A)		 1amk TRIOSE PHOSPHATE
ISOMERASE
(Leishmania
mexicana) 		3 / 3 TRP A  12
ALA A  64
VAL A  41
 None
 0.81A 1kqeB-1amkA:
undetectable
1kqeD-1amkA:
undetectable		 1kqeB-1amkA:
11.43
1kqeD-1amkA:
11.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQE_E_DVAE6_0
(MINI-GRAMICIDIN A)		 1amk TRIOSE PHOSPHATE
ISOMERASE
(Leishmania
mexicana) 		3 / 3 TRP A  12
ALA A  64
VAL A  41
 None
 0.80A 1kqeA-1amkA:
undetectable
1kqeE-1amkA:
undetectable		 1kqeA-1amkA:
11.43
1kqeE-1amkA:
11.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_D_SNLD4001_2
(MINERALOCORTICOID
RECEPTOR)		 1amk TRIOSE PHOSPHATE
ISOMERASE
(Leishmania
mexicana) 		4 / 5 LEU A 209
LEU A 206
MET A 122
THR A 249
 None
 1.30A 2oaxD-1amkA:
undetectable		 2oaxD-1amkA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VUF_B_FUAB2002_1
(SERUM ALBUMIN)		 1amk TRIOSE PHOSPHATE
ISOMERASE
(Leishmania
mexicana) 		4 / 9 ALA A 110
VAL A 113
CYH A 117
LYS A 118
 None
 0.67A 2vufB-1amkA:
0.0		 2vufB-1amkA:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X1L_A_ADNA601_1
(METHIONYL-TRNA
SYNTHETASE)		 1amk TRIOSE PHOSPHATE
ISOMERASE
(Leishmania
mexicana) 		5 / 11 ALA A 165
GLY A 234
GLU A 167
ILE A 124
HIS A  95
 None
PGA  A 600 (-3.3A)
PGA  A 600 (-2.4A)
None
PGA  A 600 (-4.0A)
 1.09A 2x1lA-1amkA:
undetectable		 2x1lA-1amkA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X1L_C_ADNC601_1
(METHIONYL-TRNA
SYNTHETASE)		 1amk TRIOSE PHOSPHATE
ISOMERASE
(Leishmania
mexicana) 		5 / 11 ALA A 165
GLY A 234
GLU A 167
ILE A 124
HIS A  95
 None
PGA  A 600 (-3.3A)
PGA  A 600 (-2.4A)
None
PGA  A 600 (-4.0A)
 1.12A 2x1lC-1amkA:
undetectable		 2x1lC-1amkA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUJ_A_CAMA422_0
(CAMPHOR
5-MONOOXYGENASE)		 1amk TRIOSE PHOSPHATE
ISOMERASE
(Leishmania
mexicana) 		4 / 8 VAL A 109
VAL A 162
LEU A 164
VAL A 123
 None
 0.88A 2zujA-1amkA:
0.0		 2zujA-1amkA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROX_A_TEPA266_1
(APOLIPOPROTEIN
A-I-BINDING PROTEIN)		 1amk TRIOSE PHOSPHATE
ISOMERASE
(Leishmania
mexicana) 		4 / 8 ALA A 183
VAL A 186
LEU A 190
LEU A 209
 None
 0.59A 3roxA-1amkA:
undetectable		 3roxA-1amkA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_B_715B801_2
(DIPEPTIDYL PEPTIDASE
4)		 1amk TRIOSE PHOSPHATE
ISOMERASE
(Leishmania
mexicana) 		3 / 3 ARG A 243
TYR A 223
ASN A 218
 None
 0.94A 4ffwB-1amkA:
undetectable		 4ffwB-1amkA:
14.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTW_A_DB8A1101_2
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-3)		 1amk TRIOSE PHOSPHATE
ISOMERASE
(Leishmania
mexicana) 		3 / 3 LEU A  93
LEU A 209
ASN A  11
 None
 0.60A 4otwA-1amkA:
undetectable		 4otwA-1amkA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1I_B_LOCB502_2
(TUBULIN BETA CHAIN)		 1amk TRIOSE PHOSPHATE
ISOMERASE
(Leishmania
mexicana) 		5 / 12 ALA A 236
ASN A 218
THR A 221
ALA A 248
ALA A   8
 None
 1.19A 4x1iB-1amkA:
undetectable		 4x1iB-1amkA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1K_D_LOCD502_2
(TUBULIN BETA CHAIN)		 1amk TRIOSE PHOSPHATE
ISOMERASE
(Leishmania
mexicana) 		5 / 12 LEU A 232
THR A  44
ALA A  42
VAL A  40
ALA A   9
 PGA  A 600 ( 4.2A)
None
None
None
None
 1.15A 4x1kD-1amkA:
2.9		 4x1kD-1amkA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XO7_A_ASDA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 1amk TRIOSE PHOSPHATE
ISOMERASE
(Leishmania
mexicana) 		4 / 7 ILE A 150
TRP A 193
LEU A 189
LEU A 190
 None
 1.01A 4xo7A-1amkA:
8.3		 4xo7A-1amkA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JH7_B_6K9B503_0
(TUBULIN BETA-2B
CHAIN)		 1amk TRIOSE PHOSPHATE
ISOMERASE
(Leishmania
mexicana) 		5 / 11 VAL A 214
SER A 213
THR A 174
TYR A 210
LEU A 222
 None
PGA  A 600 (-4.2A)
None
None
None
 1.27A 5jh7B-1amkA:
undetectable		 5jh7B-1amkA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JH7_D_6K9D502_0
(TUBULIN BETA-2B
CHAIN)		 1amk TRIOSE PHOSPHATE
ISOMERASE
(Leishmania
mexicana) 		5 / 11 GLN A 182
VAL A 214
SER A 213
THR A 174
TYR A 210
 None
None
PGA  A 600 (-4.2A)
None
None
 1.42A 5jh7D-1amkA:
undetectable		 5jh7D-1amkA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JH7_D_6K9D502_0
(TUBULIN BETA-2B
CHAIN)		 1amk TRIOSE PHOSPHATE
ISOMERASE
(Leishmania
mexicana) 		5 / 11 VAL A 214
SER A 213
THR A 174
TYR A 210
LEU A 222
 None
PGA  A 600 (-4.2A)
None
None
None
 1.26A 5jh7D-1amkA:
undetectable		 5jh7D-1amkA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_H_ACTH614_0
(NADH DEHYDROGENASE,
PUTATIVE)		 1amk TRIOSE PHOSPHATE
ISOMERASE
(Leishmania
mexicana) 		4 / 6 ILE A  21
VAL A  41
VAL A  51
TRP A  12
 None
 0.86A 5jwaH-1amkA:
undetectable		 5jwaH-1amkA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIO_A_HFGA801_0
(PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE))		 1amk TRIOSE PHOSPHATE
ISOMERASE
(Leishmania
mexicana) 		5 / 12 GLU A 167
HIS A  95
THR A 130
SER A  96
GLY A 128
 PGA  A 600 (-2.4A)
PGA  A 600 (-4.0A)
None
None
None
 1.39A 5xioA-1amkA:
undetectable		 5xioA-1amkA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z12_B_9CRB501_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1amk TRIOSE PHOSPHATE
ISOMERASE
(Leishmania
mexicana) 		3 / 3 GLN A  52
ILE A 246
HIS A  31
 None
 0.61A 5z12B-1amkA:
undetectable		 5z12B-1amkA:
18.27