SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1amu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JOM_A_FFOA161_0
(DIHYDROFOLATE
REDUCTASE)		 1amu GRAMICIDIN
SYNTHETASE 1
(Brevibacillus
brevis) 		5 / 11 ALA A 332
LEU A 210
PHE A 213
ILE A 299
THR A 355
 None
 1.24A 1jomA-1amuA:
undetectable		 1jomA-1amuA:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OHR_A_1UNA201_1
(ASPARTYLPROTEASE)		 1amu GRAMICIDIN
SYNTHETASE 1
(Brevibacillus
brevis) 		6 / 11 GLY A 373
ALA A 415
ASP A 413
THR A 333
PRO A 351
ILE A 423
 None
None
AMP  A 567 (-2.9A)
None
None
None
 1.45A 1ohrA-1amuA:
undetectable		 1ohrA-1amuA:
11.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_B_BEZB504_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 1amu GRAMICIDIN
SYNTHETASE 1
(Brevibacillus
brevis) 		4 / 7 LEU A 110
ILE A 106
ALA A 185
ILE A 330
 None
None
None
PHE  A 566 (-4.6A)
 0.96A 1oniB-1amuA:
0.0
1oniC-1amuA:
0.0		 1oniB-1amuA:
14.59
1oniC-1amuA:
14.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC2_E_NCAE507_0
(NAD-DEPENDENT
DEACETYLASE 2)		 1amu GRAMICIDIN
SYNTHETASE 1
(Brevibacillus
brevis) 		4 / 7 ILE A 352
PHE A 214
LEU A 218
ILE A 330
 None
None
None
PHE  A 566 (-4.6A)
 0.74A 1yc2E-1amuA:
undetectable		 1yc2E-1amuA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AXN_A_EDTA737_0
(6-PHOSPHOFRUCTO-2-KI
NASE/FRUCTOSE-2,6-BI
PHOSPHATASE 3
(6PF-2-K/FRU-
2,6-P2ASE
BRAIN/PLACENTA-TYPE
ISOZYME) (IPFK-2)
[INCLUDES: 6-
PHOSPHOFRUCTO-2-KINA
SE (EC 2.7.1.105)
FRUCTOSE-2,6-BISPHO
SPHATASE (EC
3.1.3.46)])		 1amu GRAMICIDIN
SYNTHETASE 1
(Brevibacillus
brevis) 		5 / 12 THR A 282
GLY A 302
ALA A 304
THR A 305
TYR A 319
 None
PHE  A 566 ( 3.6A)
AMP  A 567 (-4.1A)
None
None
 1.30A 2axnA-1amuA:
2.3		 2axnA-1amuA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BTE_A_LEUA1894_0
(AMINOACYL-TRNA
SYNTHETASE)		 1amu GRAMICIDIN
SYNTHETASE 1
(Brevibacillus
brevis) 		4 / 8 TYR A 123
ASP A 120
SER A 231
TYR A 116
 None
 1.20A 2bteA-1amuA:
undetectable		 2bteA-1amuA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_C_ZMRC3478_1
(NEURAMINIDASE)		 1amu GRAMICIDIN
SYNTHETASE 1
(Brevibacillus
brevis) 		4 / 8 SER A 231
ASP A 120
SER A 233
ASN A 515
 None
 1.10A 2cmlC-1amuA:
undetectable		 2cmlC-1amuA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_C_VIAC903_2
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 1amu GRAMICIDIN
SYNTHETASE 1
(Brevibacillus
brevis) 		3 / 3 ASN A  71
ILE A  58
MET A 241
 None
 0.80A 2h42C-1amuA:
0.0		 2h42C-1amuA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKC_A_TRPA1520_0
(FLAVIN-DEPENDENT
TRYPTOPHAN
HALOGENASE PRNA)		 1amu GRAMICIDIN
SYNTHETASE 1
(Brevibacillus
brevis) 		5 / 10 ILE A 188
PRO A 118
ILE A 330
TYR A 123
ASN A 515
 None
None
PHE  A 566 (-4.6A)
None
None
 1.42A 2jkcA-1amuA:
1.1		 2jkcA-1amuA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NMY_A_ROCA401_1
(PROTEASE)		 1amu GRAMICIDIN
SYNTHETASE 1
(Brevibacillus
brevis) 		6 / 12 GLY A 373
ALA A 415
ASP A 413
THR A 333
PRO A 351
ILE A 423
 None
None
AMP  A 567 (-2.9A)
None
None
None
 1.42A 2nmyA-1amuA:
undetectable		 2nmyA-1amuA:
10.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7B_A_BEZA1529_0
(BENZOATE-COENZYME A
LIGASE)		 1amu GRAMICIDIN
SYNTHETASE 1
(Brevibacillus
brevis) 		5 / 9 PHE A 234
ALA A 301
GLY A 302
GLY A 324
LYS A 517
 PHE  A 566 ( 4.5A)
PHE  A 566 (-3.4A)
PHE  A 566 ( 3.6A)
PHE  A 566 (-4.7A)
AMP  A 567 ( 2.8A)
 0.64A 2v7bA-1amuA:
45.7		 2v7bA-1amuA:
25.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7B_B_BEZB1529_0
(BENZOATE-COENZYME A
LIGASE)		 1amu GRAMICIDIN
SYNTHETASE 1
(Brevibacillus
brevis) 		5 / 9 PHE A 234
ALA A 301
GLY A 302
GLY A 324
LYS A 517
 PHE  A 566 ( 4.5A)
PHE  A 566 (-3.4A)
PHE  A 566 ( 3.6A)
PHE  A 566 (-4.7A)
AMP  A 567 ( 2.8A)
 0.65A 2v7bB-1amuA:
45.7		 2v7bB-1amuA:
25.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D1Y_A_ROCA201_1
(HIV-1 PROTEASE)		 1amu GRAMICIDIN
SYNTHETASE 1
(Brevibacillus
brevis) 		6 / 12 GLY A 373
ALA A 415
ASP A 413
THR A 333
PRO A 351
ILE A 423
 None
None
AMP  A 567 (-2.9A)
None
None
None
 1.42A 3d1yA-1amuA:
undetectable		 3d1yA-1amuA:
10.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB200_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 1amu GRAMICIDIN
SYNTHETASE 1
(Brevibacillus
brevis) 		4 / 5 PRO A 118
THR A 513
GLY A 516
LYS A 517
 None
None
None
AMP  A 567 ( 2.8A)
 1.20A 3elzB-1amuA:
0.0		 3elzB-1amuA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KW4_A_TICA600_1
(CYTOCHROME P450 2B4)		 1amu GRAMICIDIN
SYNTHETASE 1
(Brevibacillus
brevis) 		5 / 11 ILE A 348
ILE A 359
GLU A 374
THR A 411
ILE A 377
 None
 0.96A 3kw4A-1amuA:
0.0		 3kw4A-1amuA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QEL_B_QELB1_1
(NMDA GLUTAMATE
RECEPTOR SUBUNIT
GLUTAMATE [NMDA]
RECEPTOR SUBUNIT
EPSILON-2)		 1amu GRAMICIDIN
SYNTHETASE 1
(Brevibacillus
brevis) 		5 / 11 LEU A 202
ALA A 332
ILE A 352
THR A 190
GLU A 327
 None
None
None
AMP  A 567 (-3.8A)
MG  A 564 (-2.8A)
 1.25A 3qelA-1amuA:
3.0
3qelB-1amuA:
3.2		 3qelA-1amuA:
21.92
3qelB-1amuA:
22.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3VNS_A_DVAA602_0
(NRPS ADENYLATION
PROTEIN CYTC1)		 1amu GRAMICIDIN
SYNTHETASE 1
(Brevibacillus
brevis) 		5 / 7 PHE A 234
ASP A 235
GLY A 302
THR A 326
LYS A 517
 PHE  A 566 ( 4.5A)
PHE  A 566 (-2.8A)
PHE  A 566 ( 3.6A)
AMP  A 567 ( 3.9A)
AMP  A 567 ( 2.8A)
 0.52A 3vnsA-1amuA:
49.8		 3vnsA-1amuA:
31.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WXO_A_NIZA804_1
(CATALASE-PEROXIDASE)		 1amu GRAMICIDIN
SYNTHETASE 1
(Brevibacillus
brevis) 		3 / 3 ASN A 354
GLU A 380
ARG A  37
 None
 0.94A 3wxoA-1amuA:
0.0		 3wxoA-1amuA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_C_IMNC701_1
(CYCLOOXYGENASE-2)		 1amu GRAMICIDIN
SYNTHETASE 1
(Brevibacillus
brevis) 		5 / 12 LEU A 107
VAL A 109
GLY A 113
ALA A 112
LEU A 175
 None
 1.16A 4coxC-1amuA:
0.0		 4coxC-1amuA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RMJ_A_NCAA402_0
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-2)		 1amu GRAMICIDIN
SYNTHETASE 1
(Brevibacillus
brevis) 		4 / 7 ILE A 352
PHE A 214
LEU A 218
ILE A 330
 None
None
None
PHE  A 566 (-4.6A)
 0.63A 4rmjA-1amuA:
undetectable		 4rmjA-1amuA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WQ5_B_ACTB404_0
(TRNA N6-ADENOSINE
THREONYLCARBAMOYLTRA
NSFERASE)		 1amu GRAMICIDIN
SYNTHETASE 1
(Brevibacillus
brevis) 		3 / 3 TYR A 130
ARG A 389
LYS A 197
 None
 0.83A 4wq5B-1amuA:
0.0		 4wq5B-1amuA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZXI_A_GLYA1402_0
(TYROCIDINE
SYNTHETASE 3)		 1amu GRAMICIDIN
SYNTHETASE 1
(Brevibacillus
brevis) 		5 / 7 PHE A 234
ASP A 235
GLY A 302
THR A 326
LYS A 517
 PHE  A 566 ( 4.5A)
PHE  A 566 (-2.8A)
PHE  A 566 ( 3.6A)
AMP  A 567 ( 3.9A)
AMP  A 567 ( 2.8A)
 0.27A 4zxiA-1amuA:
49.6		 4zxiA-1amuA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_O_BEZO801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 1amu GRAMICIDIN
SYNTHETASE 1
(Brevibacillus
brevis) 		4 / 6 SER A 461
HIS A 463
PRO A 526
LEU A 523
 None
 1.29A 5dzka-1amuA:
undetectable
5dzko-1amuA:
undetectable		 5dzka-1amuA:
16.58
5dzko-1amuA:
1.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWJ_D_QELD503_1
(NMDA GLUTAMATE
RECEPTOR SUBUNIT
GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 2B)		 1amu GRAMICIDIN
SYNTHETASE 1
(Brevibacillus
brevis) 		5 / 12 LEU A 202
ALA A 332
ILE A 352
THR A 190
GLU A 327
 None
None
None
AMP  A 567 (-3.8A)
MG  A 564 (-2.8A)
 1.20A 5ewjC-1amuA:
3.6
5ewjD-1amuA:
3.0		 5ewjC-1amuA:
21.83
5ewjD-1amuA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IWU_A_ACTA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 1amu GRAMICIDIN
SYNTHETASE 1
(Brevibacillus
brevis) 		4 / 6 PHE A  81
VAL A 109
MET A  96
ILE A  94
 None
 1.15A 5iwuA-1amuA:
0.0		 5iwuA-1amuA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JW1_B_CELB602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1amu GRAMICIDIN
SYNTHETASE 1
(Brevibacillus
brevis) 		4 / 6 VAL A 317
VAL A 284
ILE A 259
PHE A 229
 None
 0.87A 5jw1B-1amuA:
0.0		 5jw1B-1amuA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC0_A_RBFA303_2
(RIBOFLAVIN
TRANSPORTER RIBU)		 1amu GRAMICIDIN
SYNTHETASE 1
(Brevibacillus
brevis) 		3 / 3 LYS A  39
LEU A 110
ILE A 207
 None
 0.73A 5kc0A-1amuA:
0.0		 5kc0A-1amuA:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC4_A_RBFA201_2
(RIBOFLAVIN
TRANSPORTER RIBU)		 1amu GRAMICIDIN
SYNTHETASE 1
(Brevibacillus
brevis) 		3 / 3 LYS A  39
LEU A 110
ILE A 207
 None
 0.80A 5kc4A-1amuA:
0.0		 5kc4A-1amuA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5K_C_ADNC502_2
(ADENOSYLHOMOCYSTEINA
SE)		 1amu GRAMICIDIN
SYNTHETASE 1
(Brevibacillus
brevis) 		4 / 4 GLN A 356
THR A  31
THR A 334
LEU A 210
 None
 1.44A 5m5kC-1amuA:
undetectable		 5m5kC-1amuA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M66_B_ADNB502_2
(ADENOSYLHOMOCYSTEINA
SE)		 1amu GRAMICIDIN
SYNTHETASE 1
(Brevibacillus
brevis) 		4 / 4 GLN A 356
THR A  31
THR A 334
LEU A 210
 None
 1.42A 5m66B-1amuA:
2.5		 5m66B-1amuA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZR_E_PFLE409_1
(PROTON-GATED ION
CHANNEL)		 1amu GRAMICIDIN
SYNTHETASE 1
(Brevibacillus
brevis) 		4 / 8 TYR A 116
ILE A  94
TYR A 189
ILE A 131
 None
 0.88A 5mzrE-1amuA:
0.0		 5mzrE-1amuA:
10.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5N9X_A_THRA601_0
(ADENYLATION DOMAIN)		 1amu GRAMICIDIN
SYNTHETASE 1
(Brevibacillus
brevis) 		5 / 7 PHE A 234
ASP A 235
GLY A 302
GLY A 324
LYS A 517
 PHE  A 566 ( 4.5A)
PHE  A 566 (-2.8A)
PHE  A 566 ( 3.6A)
PHE  A 566 (-4.7A)
AMP  A 567 ( 2.8A)
 0.65A 5n9xA-1amuA:
50.1		 5n9xA-1amuA:
30.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3M_B_ADNB502_2
(-)		 1amu GRAMICIDIN
SYNTHETASE 1
(Brevibacillus
brevis) 		4 / 4 GLN A 356
THR A  31
THR A 334
LEU A 210
 None
 1.40A 6f3mB-1amuA:
2.4		 6f3mB-1amuA:
23.27