SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ao0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A29_A_TFPA153_1
(CALMODULIN)
1ao0 GLUTAMINE
PHOSPHORIBOSYLPYROPH
OSPHATE
AMIDOTRANSFERASE

(Bacillus
subtilis)
5 / 8 LEU A 303
MET A 360
GLU A 363
ALA A 364
VAL A 336
None
1.00A 1a29A-1ao0A:
undetectable
1a29A-1ao0A:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4Y_A_TPVA501_1
(PROTEIN (HIV-1
PROTEASE))
1ao0 GLUTAMINE
PHOSPHORIBOSYLPYROPH
OSPHATE
AMIDOTRANSFERASE

(Bacillus
subtilis)
5 / 10 LEU A 215
ASP A 219
GLY A  66
ILE A   6
VAL A 170
None
1.12A 1d4yA-1ao0A:
undetectable
1d4yA-1ao0A:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H9Z_A_RWFA3001_1
(SERUM ALBUMIN)
1ao0 GLUTAMINE
PHOSPHORIBOSYLPYROPH
OSPHATE
AMIDOTRANSFERASE

(Bacillus
subtilis)
5 / 11 PHE A 198
ALA A 197
LEU A  23
ARG A  26
LEU A 161
None
1.06A 1h9zA-1ao0A:
undetectable
1h9zA-1ao0A:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HA2_A_SWFA3001_1
(SERUM ALBUMIN)
1ao0 GLUTAMINE
PHOSPHORIBOSYLPYROPH
OSPHATE
AMIDOTRANSFERASE

(Bacillus
subtilis)
5 / 11 PHE A 198
ALA A 197
LEU A  23
ARG A  26
LEU A 161
None
1.04A 1ha2A-1ao0A:
undetectable
1ha2A-1ao0A:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Z_A_COCA301_1
(CHIMERA OF IG KAPPA
CHAIN: HUMAN
CONSTANT REGION AND
MOUSE VARIABLE
REGION)
1ao0 GLUTAMINE
PHOSPHORIBOSYLPYROPH
OSPHATE
AMIDOTRANSFERASE

(Bacillus
subtilis)
4 / 8 TYR A 299
TYR A 291
LEU A 266
SER A 284
None
None
None
MG  A 469 ( 4.4A)
1.10A 1i7zA-1ao0A:
undetectable
1i7zA-1ao0A:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Z_A_COCA301_1
(CHIMERA OF IG KAPPA
CHAIN: HUMAN
CONSTANT REGION AND
MOUSE VARIABLE
REGION)
1ao0 GLUTAMINE
PHOSPHORIBOSYLPYROPH
OSPHATE
AMIDOTRANSFERASE

(Bacillus
subtilis)
4 / 8 TYR A 384
LEU A 438
LEU A 177
SER A 234
SF4  A 466 ( 4.9A)
None
None
None
1.05A 1i7zA-1ao0A:
undetectable
1i7zA-1ao0A:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_5
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)
1ao0 GLUTAMINE
PHOSPHORIBOSYLPYROPH
OSPHATE
AMIDOTRANSFERASE

(Bacillus
subtilis)
3 / 3 THR A 412
LEU A 413
VAL A 401
None
0.64A 1mz9E-1ao0A:
0.0
1mz9E-1ao0A:
7.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_C_8MOC501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)
1ao0 GLUTAMINE
PHOSPHORIBOSYLPYROPH
OSPHATE
AMIDOTRANSFERASE

(Bacillus
subtilis)
5 / 10 ILE A 395
GLY A 351
ILE A 373
LEU A 413
PHE A 415
None
5GP  A 467 (-3.2A)
None
None
None
0.97A 1z11C-1ao0A:
0.0
1z11C-1ao0A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_D_8MOD501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)
1ao0 GLUTAMINE
PHOSPHORIBOSYLPYROPH
OSPHATE
AMIDOTRANSFERASE

(Bacillus
subtilis)
5 / 10 ILE A 395
GLY A 351
ILE A 373
LEU A 413
PHE A 415
None
5GP  A 467 (-3.2A)
None
None
None
0.96A 1z11D-1ao0A:
0.0
1z11D-1ao0A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVS_B_MK1B902_3
(POL POLYPROTEIN)
1ao0 GLUTAMINE
PHOSPHORIBOSYLPYROPH
OSPHATE
AMIDOTRANSFERASE

(Bacillus
subtilis)
5 / 12 GLY A  30
ALA A  31
ILE A  33
VAL A   3
ILE A  50
None
1.00A 2avsB-1ao0A:
undetectable
2avsB-1ao0A:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJP_A_KLNA413_1
(CYTOCHROME P450
113A1)
1ao0 GLUTAMINE
PHOSPHORIBOSYLPYROPH
OSPHATE
AMIDOTRANSFERASE

(Bacillus
subtilis)
5 / 12 LEU A 161
ALA A 100
THR A 128
GLN A 146
ILE A 147
None
1.18A 2jjpA-1ao0A:
0.0
2jjpA-1ao0A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_A_SAMA302_1
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)
1ao0 GLUTAMINE
PHOSPHORIBOSYLPYROPH
OSPHATE
AMIDOTRANSFERASE

(Bacillus
subtilis)
3 / 3 THR A 388
ASP A 127
SER A 125
SF4  A 466 ( 4.1A)
None
None
0.47A 2nxeA-1ao0A:
3.1
2nxeA-1ao0A:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_B_SAMB303_1
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)
1ao0 GLUTAMINE
PHOSPHORIBOSYLPYROPH
OSPHATE
AMIDOTRANSFERASE

(Bacillus
subtilis)
3 / 3 THR A 388
ASP A 127
SER A 125
SF4  A 466 ( 4.1A)
None
None
0.43A 2nxeB-1ao0A:
3.1
2nxeB-1ao0A:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4L_A_TPVA403_2
(PROTEASE)
1ao0 GLUTAMINE
PHOSPHORIBOSYLPYROPH
OSPHATE
AMIDOTRANSFERASE

(Bacillus
subtilis)
6 / 12 GLY A  30
ALA A  31
ILE A  33
GLY A  69
VAL A   3
ILE A  50
None
1.21A 2o4lB-1ao0A:
0.0
2o4lB-1ao0A:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMM_B_SAMB301_0
(UPF0217 PROTEIN
AF_1056)
1ao0 GLUTAMINE
PHOSPHORIBOSYLPYROPH
OSPHATE
AMIDOTRANSFERASE

(Bacillus
subtilis)
6 / 11 ILE A  68
GLY A  69
GLY A  32
LEU A  97
SER A  96
LEU A  41
None
1.25A 2qmmA-1ao0A:
undetectable
2qmmB-1ao0A:
undetectable
2qmmA-1ao0A:
20.59
2qmmB-1ao0A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X1L_C_ADNC601_1
(METHIONYL-TRNA
SYNTHETASE)
1ao0 GLUTAMINE
PHOSPHORIBOSYLPYROPH
OSPHATE
AMIDOTRANSFERASE

(Bacillus
subtilis)
5 / 11 ALA A 157
ALA A 159
HIS A  70
GLY A 385
ASP A 387
None
1.06A 2x1lC-1ao0A:
undetectable
2x1lC-1ao0A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKQ_A_ROCA100_1
(PROTEASE)
1ao0 GLUTAMINE
PHOSPHORIBOSYLPYROPH
OSPHATE
AMIDOTRANSFERASE

(Bacillus
subtilis)
5 / 12 GLY A  30
ALA A  31
VAL A   3
GLY A   2
ILE A  50
None
0.58A 3ekqA-1ao0A:
undetectable
3ekqA-1ao0A:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKW_B_DR7B100_2
(PROTEASE)
1ao0 GLUTAMINE
PHOSPHORIBOSYLPYROPH
OSPHATE
AMIDOTRANSFERASE

(Bacillus
subtilis)
5 / 12 GLY A  30
ALA A  31
VAL A   3
GLY A   2
ILE A  50
None
0.83A 3ekwB-1ao0A:
undetectable
3ekwB-1ao0A:
13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_B_CELB1701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)
1ao0 GLUTAMINE
PHOSPHORIBOSYLPYROPH
OSPHATE
AMIDOTRANSFERASE

(Bacillus
subtilis)
4 / 6 VAL A 454
SER A 125
LEU A 134
ALA A 108
None
0.71A 3kk6B-1ao0A:
0.0
3kk6B-1ao0A:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU5_B_478B401_2
(PROTEASE)
1ao0 GLUTAMINE
PHOSPHORIBOSYLPYROPH
OSPHATE
AMIDOTRANSFERASE

(Bacillus
subtilis)
5 / 12 GLY A  30
ALA A  31
ILE A  33
VAL A   3
ILE A  50
None
1.07A 3nu5B-1ao0A:
undetectable
3nu5B-1ao0A:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU9_A_478A401_1
(PROTEASE)
1ao0 GLUTAMINE
PHOSPHORIBOSYLPYROPH
OSPHATE
AMIDOTRANSFERASE

(Bacillus
subtilis)
4 / 8 ALA A 287
GLY A 424
ILE A 425
PRO A 376
None
0.76A 3nu9A-1ao0A:
undetectable
3nu9A-1ao0A:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NY4_A_SMXA309_1
(BETA-LACTAMASE)
1ao0 GLUTAMINE
PHOSPHORIBOSYLPYROPH
OSPHATE
AMIDOTRANSFERASE

(Bacillus
subtilis)
4 / 5 ILE A 378
ARG A 178
THR A 388
GLU A 239
None
None
SF4  A 466 ( 4.1A)
None
1.37A 3ny4A-1ao0A:
0.0
3ny4A-1ao0A:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_B_SAMB6735_0
(16S RRNA METHYLASE)
1ao0 GLUTAMINE
PHOSPHORIBOSYLPYROPH
OSPHATE
AMIDOTRANSFERASE

(Bacillus
subtilis)
5 / 12 GLY A  46
PRO A  86
LEU A  49
THR A  16
LEU A  20
None
1.00A 3p2kB-1ao0A:
2.1
3p2kB-1ao0A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DM8_B_REAB1501_1
(RETINOIC ACID
RECEPTOR BETA)
1ao0 GLUTAMINE
PHOSPHORIBOSYLPYROPH
OSPHATE
AMIDOTRANSFERASE

(Bacillus
subtilis)
5 / 12 LEU A  99
ALA A 100
LEU A  20
ILE A  33
GLY A  19
None
1.10A 4dm8B-1ao0A:
0.0
4dm8B-1ao0A:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HFP_B_15UB402_1
(PROTHROMBIN)
1ao0 GLUTAMINE
PHOSPHORIBOSYLPYROPH
OSPHATE
AMIDOTRANSFERASE

(Bacillus
subtilis)
6 / 12 LEU A 105
ALA A 100
ASP A 387
GLY A 103
CYH A   1
GLY A 385
None
1.25A 4hfpB-1ao0A:
undetectable
4hfpB-1ao0A:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NPT_A_017A401_1
(PROTEASE)
1ao0 GLUTAMINE
PHOSPHORIBOSYLPYROPH
OSPHATE
AMIDOTRANSFERASE

(Bacillus
subtilis)
5 / 9 ALA A 287
GLY A 424
ILE A 425
ILE A 373
VAL A 344
None
1.15A 4nptA-1ao0A:
0.0
4nptA-1ao0A:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6V_E_RBFE201_1
(NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT B
NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT E)
1ao0 GLUTAMINE
PHOSPHORIBOSYLPYROPH
OSPHATE
AMIDOTRANSFERASE

(Bacillus
subtilis)
4 / 5 HIS A 370
VAL A 369
GLU A 368
VAL A 272
None
1.47A 4p6vB-1ao0A:
0.0
4p6vE-1ao0A:
0.0
4p6vB-1ao0A:
23.14
4p6vE-1ao0A:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_D_SAMD301_0
(PUTATIVE
METHYLTRANSFERASE
BUD23)
1ao0 GLUTAMINE
PHOSPHORIBOSYLPYROPH
OSPHATE
AMIDOTRANSFERASE

(Bacillus
subtilis)
5 / 12 GLY A   5
GLY A  69
ILE A  15
SER A 193
ALA A 192
None
1.12A 4qtuD-1ao0A:
undetectable
4qtuD-1ao0A:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R1Z_A_AERA601_1
(CYP17A1 PROTEIN)
1ao0 GLUTAMINE
PHOSPHORIBOSYLPYROPH
OSPHATE
AMIDOTRANSFERASE

(Bacillus
subtilis)
5 / 9 ALA A  98
ILE A 217
GLY A  66
ALA A  67
THR A  16
None
0.94A 4r1zA-1ao0A:
undetectable
4r1zA-1ao0A:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJO_A_ERYA1101_0
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)
1ao0 GLUTAMINE
PHOSPHORIBOSYLPYROPH
OSPHATE
AMIDOTRANSFERASE

(Bacillus
subtilis)
5 / 12 SER A 126
ALA A 100
ASP A 387
GLU A 239
THR A 388
None
None
None
None
SF4  A 466 ( 4.1A)
1.42A 4zjoA-1ao0A:
0.6
4zjoA-1ao0A:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_B_X2NB590_1
(CYP51 VARIANT1)
1ao0 GLUTAMINE
PHOSPHORIBOSYLPYROPH
OSPHATE
AMIDOTRANSFERASE

(Bacillus
subtilis)
5 / 12 GLY A  27
GLN A  24
LEU A 180
ILE A 216
HIS A  70
None
1.18A 5fsaB-1ao0A:
undetectable
5fsaB-1ao0A:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1N_F_DVAF9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)
1ao0 GLUTAMINE
PHOSPHORIBOSYLPYROPH
OSPHATE
AMIDOTRANSFERASE

(Bacillus
subtilis)
3 / 3 ALA A 258
ASN A 261
LEU A 262
None
0.41A 5i1nC-1ao0A:
0.0
5i1nC-1ao0A:
5.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1O_F_DVAF9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)
1ao0 GLUTAMINE
PHOSPHORIBOSYLPYROPH
OSPHATE
AMIDOTRANSFERASE

(Bacillus
subtilis)
3 / 3 ALA A 258
ASN A 261
LEU A 262
None
0.41A 5i1oC-1ao0A:
0.0
5i1oC-1ao0A:
5.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1P_F_DVAF9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)
1ao0 GLUTAMINE
PHOSPHORIBOSYLPYROPH
OSPHATE
AMIDOTRANSFERASE

(Bacillus
subtilis)
3 / 3 ALA A 258
ASN A 261
LEU A 262
None
0.36A 5i1pA-1ao0A:
0.0
5i1pA-1ao0A:
6.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1P_G_DVAG9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)
1ao0 GLUTAMINE
PHOSPHORIBOSYLPYROPH
OSPHATE
AMIDOTRANSFERASE

(Bacillus
subtilis)
3 / 3 ALA A 258
ASN A 261
LEU A 262
None
0.47A 5i1pD-1ao0A:
0.0
5i1pD-1ao0A:
6.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M0I_B_ACTB303_0
(SWI5-DEPENDENT HO
EXPRESSION PROTEIN 2)
1ao0 GLUTAMINE
PHOSPHORIBOSYLPYROPH
OSPHATE
AMIDOTRANSFERASE

(Bacillus
subtilis)
4 / 5 VAL A 106
THR A 447
ASN A 175
ASP A 173
None
1.20A 5m0iB-1ao0A:
0.0
5m0iB-1ao0A:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_H_RITH602_1
(CYTOCHROME P450 3A5)
1ao0 GLUTAMINE
PHOSPHORIBOSYLPYROPH
OSPHATE
AMIDOTRANSFERASE

(Bacillus
subtilis)
5 / 12 LEU A  97
PHE A 160
GLY A  69
ILE A 147
GLY A   5
None
1.06A 5veuH-1ao0A:
0.0
5veuH-1ao0A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AK3_A_P2EA1201_1
(PROSTAGLANDIN E2
RECEPTOR EP3
SUBTYPE,SOLUBLE
CYTOCHROME B562)
1ao0 GLUTAMINE
PHOSPHORIBOSYLPYROPH
OSPHATE
AMIDOTRANSFERASE

(Bacillus
subtilis)
4 / 4 PRO A  13
MET A 185
GLY A 183
VAL A 201
None
1.39A 6ak3A-1ao0A:
0.0
6ak3A-1ao0A:
11.26