SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ao3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_A_9CRA165_2
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 1ao3 VON WILLEBRAND
FACTOR
(Homo
sapiens) 		4 / 7 PHE A 138
LEU A   9
PHE A  32
VAL A 176
 None
 0.90A 1epbA-1ao3A:
0.1		 1epbA-1ao3A:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_B_9CRB165_2
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 1ao3 VON WILLEBRAND
FACTOR
(Homo
sapiens) 		4 / 8 PHE A 138
LEU A   9
PHE A  32
VAL A 176
 None
 0.87A 1epbB-1ao3A:
0.0		 1epbB-1ao3A:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RH3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 1ao3 VON WILLEBRAND
FACTOR
(Homo
sapiens) 		5 / 12 ILE A 140
LEU A  10
SER A  83
ILE A  85
LEU A 154
 None
 1.09A 1rh3A-1ao3A:
undetectable		 1rh3A-1ao3A:
26.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKT_D_017D200_2
(PROTEASE)		 1ao3 VON WILLEBRAND
FACTOR
(Homo
sapiens) 		5 / 11 LEU A  89
ASP A 147
GLY A 141
ILE A 140
ILE A  85
 None
 1.13A 3ektD-1ao3A:
undetectable		 3ektD-1ao3A:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU6_B_478B401_2
(PROTEASE)		 1ao3 VON WILLEBRAND
FACTOR
(Homo
sapiens) 		5 / 10 LEU A  89
ASP A 147
GLY A 141
ILE A 140
ILE A  85
 None
 1.11A 3nu6B-1ao3A:
undetectable		 3nu6B-1ao3A:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_C_ZPCC1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 1ao3 VON WILLEBRAND
FACTOR
(Homo
sapiens) 		5 / 12 VAL A  73
ILE A  33
GLU A  24
ILE A 169
VAL A  45
 None
 1.14A 4a97B-1ao3A:
undetectable
4a97C-1ao3A:
undetectable		 4a97B-1ao3A:
21.82
4a97C-1ao3A:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BLV_B_SAMB1281_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 1ao3 VON WILLEBRAND
FACTOR
(Homo
sapiens) 		5 / 12 ASP A  12
GLY A  81
SER A  14
LEU A  89
ASP A 117
 None
 1.22A 4blvB-1ao3A:
undetectable		 4blvB-1ao3A:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOR_A_FLPA711_1
(LACTOTRANSFERRIN)		 1ao3 VON WILLEBRAND
FACTOR
(Homo
sapiens) 		4 / 7 VAL A 112
PRO A 139
ASN A 162
GLY A 141
 None
 0.86A 4forA-1ao3A:
undetectable		 4forA-1ao3A:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KBW_A_RBFA201_1
(RIBOFLAVIN
TRANSPORTER RIBU)		 1ao3 VON WILLEBRAND
FACTOR
(Homo
sapiens) 		5 / 12 LEU A 154
ASP A 160
GLY A 159
ASN A 162
ALA A 130
 None
 1.38A 5kbwA-1ao3A:
undetectable		 5kbwA-1ao3A:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC0_A_RBFA303_1
(RIBOFLAVIN
TRANSPORTER RIBU)		 1ao3 VON WILLEBRAND
FACTOR
(Homo
sapiens) 		5 / 12 LEU A 154
ASP A 160
GLY A 159
ASN A 162
ALA A 130
 None
 1.36A 5kc0A-1ao3A:
0.0		 5kc0A-1ao3A:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC4_A_RBFA201_1
(RIBOFLAVIN
TRANSPORTER RIBU)		 1ao3 VON WILLEBRAND
FACTOR
(Homo
sapiens) 		5 / 12 LEU A 154
ASP A 160
GLY A 159
ASN A 162
ALA A 130
 None
 1.41A 5kc4A-1ao3A:
undetectable		 5kc4A-1ao3A:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB307_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 1ao3 VON WILLEBRAND
FACTOR
(Homo
sapiens) 		3 / 3 LEU A  89
ALA A  88
LEU A 154
 None
 0.49A 5uunB-1ao3A:
0.0		 5uunB-1ao3A:
20.77