SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ao5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QXS_A_RALA600_1
(ESTROGEN RECEPTOR)		 1ao5 GLANDULAR
KALLIKREIN-13
(Mus
musculus) 		5 / 12 THR A 161
ALA A 183
LEU A 181
LEU A 199
PRO A 130
 None
 1.13A 2qxsA-1ao5A:
undetectable		 2qxsA-1ao5A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QXS_B_RALB600_1
(ESTROGEN RECEPTOR)		 1ao5 GLANDULAR
KALLIKREIN-13
(Mus
musculus) 		5 / 12 THR A 161
ALA A 183
LEU A 181
LEU A 199
PRO A 130
 None
 1.14A 2qxsB-1ao5A:
undetectable		 2qxsB-1ao5A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARU_A_PNXA608_1
(CHITINASE A)		 1ao5 GLANDULAR
KALLIKREIN-13
(Mus
musculus) 		4 / 6 TRP A 141
SER A 139
ALA A 138
ASP A 194
 None
 1.26A 3aruA-1ao5A:
0.3		 3aruA-1ao5A:
17.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GY3_A_PNTA246_0
(CATIONIC TRYPSIN)		 1ao5 GLANDULAR
KALLIKREIN-13
(Mus
musculus) 		5 / 11 HIS A  57
GLN A 174
ASP A 189
SER A 195
GLY A 216
 None
 0.81A 3gy3A-1ao5A:
13.4		 3gy3A-1ao5A:
37.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RAE_F_LFXF101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		 1ao5 GLANDULAR
KALLIKREIN-13
(Mus
musculus) 		3 / 4 SER A  26
GLY A  19
GLU A 185
 None
 0.66A 3raeA-1ao5A:
0.0
3raeC-1ao5A:
0.0		 3raeA-1ao5A:
16.53
3raeC-1ao5A:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_C_ACTC4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 1ao5 GLANDULAR
KALLIKREIN-13
(Mus
musculus) 		4 / 4 GLY A  44
GLY A 197
THR A 212
LEU A 209
 None
 0.85A 3si7C-1ao5A:
0.0
3si7D-1ao5A:
0.0		 3si7C-1ao5A:
21.09
3si7D-1ao5A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L6V_1_PQN12001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
FUSION PROTEIN OF
PHOTOSYSTEM I
SUBUNIT III AND
SUBUNIT IX)		 1ao5 GLANDULAR
KALLIKREIN-13
(Mus
musculus) 		5 / 11 SER A 139
GLY A 140
ALA A  32
GLY A 196
ALA A 246
 None
 1.11A 4l6v1-1ao5A:
undetectable
4l6v6-1ao5A:
undetectable		 4l6v1-1ao5A:
13.99
4l6v6-1ao5A:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_D_29SD601_1
(ESTROGEN RECEPTOR)		 1ao5 GLANDULAR
KALLIKREIN-13
(Mus
musculus) 		5 / 12 THR A 161
ALA A 183
LEU A 181
LEU A 199
PRO A 130
 None
 1.09A 4xi3D-1ao5A:
undetectable		 4xi3D-1ao5A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUG_A_VIVA301_1
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 1ao5 GLANDULAR
KALLIKREIN-13
(Mus
musculus) 		3 / 3 SER A 214
SER A 195
PHE A  94
 None
 0.91A 5mugA-1ao5A:
undetectable		 5mugA-1ao5A:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 1ao5 GLANDULAR
KALLIKREIN-13
(Mus
musculus) 		4 / 6 VAL A  31
LEU A  46
ARG A  83
VAL A  66
 None
 0.95A 5x7zA-1ao5A:
undetectable		 5x7zA-1ao5A:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_D_ADND502_1
(ADENOSYLHOMOCYSTEINA
SE)		 1ao5 GLANDULAR
KALLIKREIN-13
(Mus
musculus) 		3 / 3 LEU A 181
ASN A 235
LEU A 103
 None
 0.63A 6exiD-1ao5A:
undetectable		 6exiD-1ao5A:
15.00