SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1aoa'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IGX_A_EPAA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 1aoa T-FIMBRIN
(Homo
sapiens) 		5 / 8 VAL A 211
VAL A 165
SER A 203
ILE A 207
LEU A 230
 VAL  A 211 ( 0.6A)
VAL  A 165 ( 0.6A)
SER  A 203 ( 0.0A)
ILE  A 207 ( 0.7A)
LEU  A 230 ( 0.6A)
 1.34A 1igxA-1aoaA:
undetectable		 1igxA-1aoaA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LHV_A_NOGA301_1
(SEX HORMONE-BINDING
GLOBULIN)		 1aoa T-FIMBRIN
(Homo
sapiens) 		4 / 8 THR A 354
ASP A 357
PHE A 352
ASN A 362
 THR  A 354 ( 0.8A)
ASP  A 357 ( 0.6A)
PHE  A 352 ( 1.3A)
ASN  A 362 ( 0.6A)
 0.97A 1lhvA-1aoaA:
undetectable		 1lhvA-1aoaA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RMT_C_ADNC1503_1
(CLASS B ACID
PHOSPHATASE)		 1aoa T-FIMBRIN
(Homo
sapiens) 		4 / 8 PHE A 369
LEU A 341
GLY A 348
ASP A 345
 PHE  A 369 ( 1.3A)
LEU  A 341 ( 0.6A)
GLY  A 348 ( 0.0A)
ASP  A 345 ( 0.6A)
 1.02A 1rmtC-1aoaA:
undetectable		 1rmtC-1aoaA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOF_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 1aoa T-FIMBRIN
(Homo
sapiens) 		4 / 5 LEU A 306
PRO A 311
ALA A 310
ILE A 309
 LEU  A 306 ( 0.6A)
PRO  A 311 ( 1.1A)
ALA  A 310 ( 0.0A)
ILE  A 309 ( 0.3A)
 0.90A 2aofB-1aoaA:
undetectable		 2aofB-1aoaA:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_A_SALA3002_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 1aoa T-FIMBRIN
(Homo
sapiens) 		5 / 8 LEU A 201
VAL A 227
LEU A 230
VAL A 160
LEU A 166
 LEU  A 201 ( 0.6A)
VAL  A 227 ( 0.6A)
LEU  A 230 ( 0.6A)
VAL  A 160 ( 0.6A)
LEU  A 166 ( 0.6A)
 1.15A 3kp6A-1aoaA:
0.0
3kp6B-1aoaA:
0.0		 3kp6A-1aoaA:
21.77
3kp6B-1aoaA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XK8_A_PQNA845_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 1aoa T-FIMBRIN
(Homo
sapiens) 		4 / 8 ARG A 220
ALA A 216
LEU A 219
GLY A 161
 ARG  A 220 ( 0.6A)
ALA  A 216 ( 0.0A)
LEU  A 219 ( 0.6A)
GLY  A 161 ( 0.0A)
 0.91A 4xk8a-1aoaA:
undetectable		 4xk8a-1aoaA:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KLA_A_ACTA1505_0
(MATERNAL PROTEIN
PUMILIO)		 1aoa T-FIMBRIN
(Homo
sapiens) 		3 / 3 HIS A 304
LYS A 300
PHE A 328
 HIS  A 304 ( 1.0A)
LYS  A 300 ( 0.0A)
PHE  A 328 ( 1.3A)
 1.45A 5klaA-1aoaA:
undetectable		 5klaA-1aoaA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UHB_C_RFPC1201_2
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 1aoa T-FIMBRIN
(Homo
sapiens) 		3 / 3 PHE A 369
ASP A 357
LEU A 231
 PHE  A 369 ( 1.3A)
ASP  A 357 ( 0.6A)
LEU  A 231 ( 0.6A)
 0.77A 5uhbC-1aoaA:
0.0		 5uhbC-1aoaA:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UHC_C_RFPC1201_2
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 1aoa T-FIMBRIN
(Homo
sapiens) 		3 / 3 PHE A 369
ASP A 357
LEU A 231
 PHE  A 369 ( 1.3A)
ASP  A 357 ( 0.6A)
LEU  A 231 ( 0.6A)
 0.68A 5uhcC-1aoaA:
0.0		 5uhcC-1aoaA:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1aoa T-FIMBRIN
(Homo
sapiens) 		4 / 5 LEU A 281
GLN A 308
PHE A 279
PHE A 292
 LEU  A 281 ( 0.6A)
GLN  A 308 ( 0.6A)
PHE  A 279 ( 1.3A)
PHE  A 292 ( 1.3A)
 1.29A 6nmpP-1aoaA:
0.1
6nmpW-1aoaA:
0.0		 6nmpP-1aoaA:
19.49
6nmpW-1aoaA:
15.94