SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1aog'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AJV_L_COCL501_1
(ANTIBODY 7A1 FAB')		 1aog TRYPANOTHIONE
REDUCTASE
(Trypanosoma
cruzi) 		4 / 7 ALA A 285
ARG A 288
TYR A 184
PHE A 204
 None
FAD  A 492 (-3.5A)
None
None
 1.19A 2ajvH-1aogA:
undetectable
2ajvL-1aogA:
undetectable		 2ajvH-1aogA:
18.79
2ajvL-1aogA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B235_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		 1aog TRYPANOTHIONE
REDUCTASE
(Trypanosoma
cruzi) 		4 / 6 PHE A 123
PHE A 115
GLY A  14
GLY A  17
 None
None
FAD  A 492 (-3.3A)
None
 0.92A 2qr2A-1aogA:
0.0
2qr2B-1aogA:
4.1		 2qr2A-1aogA:
19.03
2qr2B-1aogA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B236_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		 1aog TRYPANOTHIONE
REDUCTASE
(Trypanosoma
cruzi) 		4 / 5 GLY A  14
GLY A  17
PHE A 123
PHE A 115
 FAD  A 492 (-3.3A)
None
None
None
 0.93A 2qr2A-1aogA:
0.0
2qr2B-1aogA:
4.1		 2qr2A-1aogA:
19.03
2qr2B-1aogA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ROX_A_T44A128_1
(TRANSTHYRETIN)		 1aog TRYPANOTHIONE
REDUCTASE
(Trypanosoma
cruzi) 		4 / 4 LYS A 414
LEU A 235
ALA A 413
LEU A 430
 None
 1.45A 2roxA-1aogA:
undetectable		 2roxA-1aogA:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DAT_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 1aog TRYPANOTHIONE
REDUCTASE
(Trypanosoma
cruzi) 		5 / 12 ALA A 465
LEU A 429
GLN A 439
LEU A 445
PHE A 454
 None
 1.10A 3datA-1aogA:
undetectable		 3datA-1aogA:
14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_B_TMQB612_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1aog TRYPANOTHIONE
REDUCTASE
(Trypanosoma
cruzi) 		5 / 9 VAL A 328
ALA A 160
THR A  52
SER A  47
PHE A  45
 None
FAD  A 492 (-4.7A)
FAD  A 492 (-3.4A)
FAD  A 492 (-2.5A)
None
 1.32A 3hbbB-1aogA:
undetectable		 3hbbB-1aogA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RAE_H_LFXH101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		 1aog TRYPANOTHIONE
REDUCTASE
(Trypanosoma
cruzi) 		4 / 5 SER A 368
GLY A 230
GLU A 379
GLU A 380
 None
 1.30A 3raeB-1aogA:
undetectable
3raeD-1aogA:
undetectable		 3raeB-1aogA:
22.43
3raeD-1aogA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SM2_A_478A126_2
(GAG-PRO-POL
POLYPROTEIN)		 1aog TRYPANOTHIONE
REDUCTASE
(Trypanosoma
cruzi) 		5 / 11 VAL A 136
GLY A  12
ALA A  13
LEU A 130
LEU A 152
 None
FAD  A 492 (-3.4A)
None
None
None
 1.05A 3sm2B-1aogA:
undetectable		 3sm2B-1aogA:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U7S_A_017A202_1
(POL POLYPROTEIN)		 1aog TRYPANOTHIONE
REDUCTASE
(Trypanosoma
cruzi) 		5 / 9 ILE A 248
GLY A 206
ILE A 207
PRO A 189
LEU A 281
 None
 1.07A 3u7sA-1aogA:
undetectable		 3u7sA-1aogA:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQ6_B_ADNB401_2
(ADENOSINE KINASE,
PUTATIVE)		 1aog TRYPANOTHIONE
REDUCTASE
(Trypanosoma
cruzi) 		4 / 5 LEU A  18
GLY A  14
PHE A 123
ASN A  55
 None
FAD  A 492 (-3.3A)
None
None
 1.06A 3uq6B-1aogA:
5.1		 3uq6B-1aogA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZTV_A_ADNA1600_1
(NAD NUCLEOTIDASE)		 1aog TRYPANOTHIONE
REDUCTASE
(Trypanosoma
cruzi) 		5 / 9 GLY A  14
GLY A  17
SER A  47
GLY A  51
ASP A  36
 FAD  A 492 (-3.3A)
None
FAD  A 492 (-2.5A)
FAD  A 492 (-3.2A)
FAD  A 492 (-3.2A)
 0.88A 3ztvA-1aogA:
undetectable		 3ztvA-1aogA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZS_A_SAMA1475_0
(METHYLTRANSFERASE
WBDD)		 1aog TRYPANOTHIONE
REDUCTASE
(Trypanosoma
cruzi) 		5 / 12 TYR A 111
GLY A  17
ALA A  13
ILE A 325
GLU A 341
 None
 1.30A 4azsA-1aogA:
2.9		 4azsA-1aogA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HTF_A_SAMA301_0
(S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 1aog TRYPANOTHIONE
REDUCTASE
(Trypanosoma
cruzi) 		5 / 12 GLY A  14
GLY A  50
ALA A  20
VAL A  34
VAL A  32
 FAD  A 492 (-3.3A)
None
None
None
None
 0.99A 4htfA-1aogA:
3.7		 4htfA-1aogA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HTF_B_SAMB301_0
(S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 1aog TRYPANOTHIONE
REDUCTASE
(Trypanosoma
cruzi) 		5 / 12 GLY A  14
GLY A  50
ALA A  20
VAL A  34
VAL A  32
 FAD  A 492 (-3.3A)
None
None
None
None
 0.95A 4htfB-1aogA:
2.6		 4htfB-1aogA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_B_LOCB503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 1aog TRYPANOTHIONE
REDUCTASE
(Trypanosoma
cruzi) 		3 / 3 SER A 475
ALA A 390
VAL A 389
 None
 0.61A 4o2bA-1aogA:
2.3		 4o2bA-1aogA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_D_LOCD503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 1aog TRYPANOTHIONE
REDUCTASE
(Trypanosoma
cruzi) 		3 / 3 SER A 475
ALA A 390
VAL A 389
 None
 0.64A 4o2bC-1aogA:
2.1		 4o2bC-1aogA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_D_SAMD301_0
(UNCHARACTERIZED
PROTEIN)		 1aog TRYPANOTHIONE
REDUCTASE
(Trypanosoma
cruzi) 		5 / 12 ALA A 390
GLY A 422
ILE A 441
GLY A 426
GLU A 379
 None
 1.03A 4r29D-1aogA:
0.0		 4r29D-1aogA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_A_URFA302_1
(URIDINE
PHOSPHORYLASE)		 1aog TRYPANOTHIONE
REDUCTASE
(Trypanosoma
cruzi) 		4 / 7 THR A 194
GLY A 196
ALA A 285
ILE A 200
 None
MAE  A 500 ( 3.9A)
None
FAD  A 492 ( 4.3A)
 0.95A 4txnA-1aogA:
undetectable		 4txnA-1aogA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_B_URFB302_1
(URIDINE
PHOSPHORYLASE)		 1aog TRYPANOTHIONE
REDUCTASE
(Trypanosoma
cruzi) 		4 / 7 THR A 194
GLY A 196
ALA A 285
ILE A 200
 None
MAE  A 500 ( 3.9A)
None
FAD  A 492 ( 4.3A)
 0.95A 4txnB-1aogA:
undetectable		 4txnB-1aogA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_C_URFC302_1
(URIDINE
PHOSPHORYLASE)		 1aog TRYPANOTHIONE
REDUCTASE
(Trypanosoma
cruzi) 		4 / 7 THR A 194
GLY A 196
ALA A 285
ILE A 200
 None
MAE  A 500 ( 3.9A)
None
FAD  A 492 ( 4.3A)
 0.96A 4txnC-1aogA:
undetectable		 4txnC-1aogA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_D_URFD302_1
(URIDINE
PHOSPHORYLASE)		 1aog TRYPANOTHIONE
REDUCTASE
(Trypanosoma
cruzi) 		4 / 7 THR A 194
GLY A 196
ALA A 285
ILE A 200
 None
MAE  A 500 ( 3.9A)
None
FAD  A 492 ( 4.3A)
 0.91A 4txnD-1aogA:
undetectable		 4txnD-1aogA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XO7_A_ASDA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 1aog TRYPANOTHIONE
REDUCTASE
(Trypanosoma
cruzi) 		4 / 7 VAL A  34
ILE A  35
LEU A 297
LEU A 130
 None
FAD  A 492 ( 4.6A)
None
None
 0.97A 4xo7A-1aogA:
undetectable		 4xo7A-1aogA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LBT_A_6T0A303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1aog TRYPANOTHIONE
REDUCTASE
(Trypanosoma
cruzi) 		5 / 10 PHE A 123
ILE A  35
PHE A 115
GLY A  14
GLY A  17
 None
FAD  A 492 ( 4.6A)
None
FAD  A 492 (-3.3A)
None
 1.08A 5lbtA-1aogA:
4.0
5lbtB-1aogA:
3.9		 5lbtA-1aogA:
18.24
5lbtB-1aogA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DYN_A_HSMA901_0
(EBONY)		 1aog TRYPANOTHIONE
REDUCTASE
(Trypanosoma
cruzi) 		4 / 4 GLU A 379
VAL A 391
LEU A 393
THR A 234
 None
 1.13A 6dynA-1aogA:
0.0		 6dynA-1aogA:
10.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DYO_A_LDPA901_0
(EBONY)		 1aog TRYPANOTHIONE
REDUCTASE
(Trypanosoma
cruzi) 		4 / 5 GLU A 379
VAL A 391
LEU A 393
THR A 234
 None
 1.20A 6dyoA-1aogA:
0.0		 6dyoA-1aogA:
10.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNR_A_6J3A201_0
(TRANSTHYRETIN)		 1aog TRYPANOTHIONE
REDUCTASE
(Trypanosoma
cruzi) 		4 / 4 LYS A 414
LEU A 235
ALA A 413
LEU A 430
 None
 1.49A 6gnrA-1aogA:
undetectable		 6gnrA-1aogA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNR_B_6J3B201_0
(TRANSTHYRETIN)		 1aog TRYPANOTHIONE
REDUCTASE
(Trypanosoma
cruzi) 		4 / 4 LYS A 414
LEU A 235
ALA A 413
LEU A 430
 None
 1.48A 6gnrB-1aogA:
undetectable		 6gnrB-1aogA:
16.94