SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1aol'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FAP_A_RAPA108_2
(FK506-BINDING
PROTEIN
FRAP)		 1aol GP70
(Murine
leukemia
virus) 		4 / 8 ARG A 225
PHE A 222
TRP A 207
PHE A 191
 None
 1.04A 1fapB-1aolA:
0.0		 1fapB-1aolA:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_A_CFXA1300_2
(BETA-LACTAMASE)		 1aol GP70
(Murine
leukemia
virus) 		4 / 5 TYR A 206
LEU A  41
THR A 202
ARG A 227
 None
 1.28A 1i2wA-1aolA:
undetectable		 1i2wA-1aolA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y4L_B_SVRB301_1
(PHOSPHOLIPASE A2
HOMOLOG 2)		 1aol GP70
(Murine
leukemia
virus) 		5 / 12 GLY A  20
GLY A  52
LEU A  58
GLY A  57
PRO A 218
 None
 1.23A 1y4lA-1aolA:
undetectable		 1y4lA-1aolA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TSR_B_D16B409_1
(THYMIDYLATE SYNTHASE)		 1aol GP70
(Murine
leukemia
virus) 		4 / 8 ARG A 225
ILE A 224
GLY A 195
PHE A 191
 None
 0.91A 2tsrB-1aolA:
0.0		 2tsrB-1aolA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_A_SALA3002_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 1aol GP70
(Murine
leukemia
virus) 		5 / 8 LEU A  48
VAL A 165
LEU A 187
VAL A 120
LEU A 209
 None
 1.29A 3kp6A-1aolA:
undetectable
3kp6B-1aolA:
0.0		 3kp6A-1aolA:
19.67
3kp6B-1aolA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NRR_A_D16A520_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1aol GP70
(Murine
leukemia
virus) 		5 / 12 ALA A 174
ASP A 108
LEU A 105
PRO A  68
THR A 171
 None
 1.04A 3nrrA-1aolA:
undetectable		 3nrrA-1aolA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NRR_B_D16B520_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1aol GP70
(Murine
leukemia
virus) 		5 / 12 ALA A 174
ASP A 108
LEU A 105
PRO A  68
THR A 171
 None
 1.04A 3nrrB-1aolA:
undetectable		 3nrrB-1aolA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFU_A_RBVA601_1
(RNA POLYMERASE)		 1aol GP70
(Murine
leukemia
virus) 		5 / 9 THR A  24
THR A  18
ASN A  19
TYR A 206
GLY A  20
 None
 1.27A 3sfuA-1aolA:
undetectable		 3sfuA-1aolA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4APJ_A_ACTA1635_0
(ANGIOTENSIN-CONVERTI
NG ENZYME
BRADYKININ-POTENTIAT
ING PEPTIDE B)		 1aol GP70
(Murine
leukemia
virus) 		4 / 6 HIS A 125
ASP A 161
SER A 158
PRO A 127
 None
 1.33A 4apjA-1aolA:
undetectable
4apjP-1aolA:
undetectable		 4apjA-1aolA:
16.90
4apjP-1aolA:
4.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KMF_A_6U9A1301_1
(ION TRANSPORT
PROTEIN)		 1aol GP70
(Murine
leukemia
virus) 		4 / 6 THR A 203
GLY A 204
TYR A 162
ILE A 163
 None
 0.88A 5kmfA-1aolA:
undetectable
5kmfC-1aolA:
undetectable		 5kmfA-1aolA:
18.15
5kmfC-1aolA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QXS_B_FOZB403_0
(THYMIDYLATE SYNTHASE)		 1aol GP70
(Murine
leukemia
virus) 		5 / 12 PRO A  39
LEU A  41
ILE A 224
GLY A 195
PHE A 191
 None
 1.02A 6qxsB-1aolA:
undetectable		 6qxsB-1aolA:
20.19