SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1aos'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_3
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 1aos ARGININOSUCCINATE
LYASE
(Homo
sapiens) 		3 / 3 THR A 128
LEU A 132
LEU A 139
 None
 0.63A 1mz9C-1aosA:
undetectable		 1mz9C-1aosA:
8.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_1
(CES1 PROTEIN)		 1aos ARGININOSUCCINATE
LYASE
(Homo
sapiens) 		5 / 12 GLY A 200
VAL A 211
SER A  42
LEU A 216
LEU A  49
 None
 1.12A 1ya4B-1aosA:
undetectable		 1ya4B-1aosA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_1
(CES1 PROTEIN)		 1aos ARGININOSUCCINATE
LYASE
(Homo
sapiens) 		5 / 12 GLY A 200
VAL A 211
SER A  42
LEU A 216
LEU A  49
 None
 1.03A 1ya4C-1aosA:
undetectable		 1ya4C-1aosA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_D_BEZD2385_0
(CES1 PROTEIN)		 1aos ARGININOSUCCINATE
LYASE
(Homo
sapiens) 		4 / 5 LEU A 373
LEU A 408
LEU A 410
LEU A 405
 None
 1.05A 1yajD-1aosA:
undetectable		 1yajD-1aosA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q7L_A_TESA155_1
(ANDROGEN RECEPTOR)		 1aos ARGININOSUCCINATE
LYASE
(Homo
sapiens) 		5 / 12 LEU A 180
LEU A 136
VAL A 342
MET A 339
MET A 256
 None
 1.40A 2q7lA-1aosA:
undetectable		 2q7lA-1aosA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R4X_A_PZAA597_0
(LACTOPEROXIDASE)		 1aos ARGININOSUCCINATE
LYASE
(Homo
sapiens) 		4 / 5 GLN A 116
ASP A 120
HIS A  89
GLU A  93
 None
 1.26A 3r4xA-1aosA:
0.0		 3r4xA-1aosA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9C_A_ECLA452_1
(CYTOCHROME P450
164A2)		 1aos ARGININOSUCCINATE
LYASE
(Homo
sapiens) 		5 / 12 SER A 175
LEU A 253
LEU A 180
ALA A 346
THR A 347
 None
 1.17A 3r9cA-1aosA:
undetectable		 3r9cA-1aosA:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_B_CHDB502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1aos ARGININOSUCCINATE
LYASE
(Homo
sapiens) 		4 / 6 PHE A 238
MET A 125
ARG A 236
VAL A 117
 None
 1.42A 4mk4B-1aosA:
undetectable		 4mk4B-1aosA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_B_29SB601_2
(ESTROGEN RECEPTOR)		 1aos ARGININOSUCCINATE
LYASE
(Homo
sapiens) 		4 / 5 LEU A 199
GLU A 219
LEU A 107
HIS A  89
 None
 1.05A 4xi3B-1aosA:
undetectable		 4xi3B-1aosA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I6X_A_8PRA705_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 1aos ARGININOSUCCINATE
LYASE
(Homo
sapiens) 		5 / 10 TYR A  45
ALA A  52
GLY A 110
SER A  46
GLY A  48
 None
 1.07A 5i6xA-1aosA:
0.0		 5i6xA-1aosA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5F_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA
TYPE-8,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)		 1aos ARGININOSUCCINATE
LYASE
(Homo
sapiens) 		4 / 8 SER A 234
ALA A 203
ASP A 115
SER A 112
 None
 1.06A 5l5fY-1aosA:
0.0
5l5fZ-1aosA:
undetectable		 5l5fY-1aosA:
18.32
5l5fZ-1aosA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B0L_B_TA1B502_1
(TUBULIN BETA CHAIN)		 1aos ARGININOSUCCINATE
LYASE
(Homo
sapiens) 		5 / 12 VAL A 211
ASP A 212
LEU A  67
LEU A 107
LEU A 220
 None
 1.13A 6b0lB-1aosA:
undetectable		 6b0lB-1aosA:
10.85