SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1aow'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_F_SC2F1291_1
(FICOLIN-2)		 1aow ANNEXIN IV
(Bos
taurus) 		4 / 6 LEU A  71
SER A  69
ASP A  66
ASP A  65
 None
 1.07A 2j2pE-1aowA:
undetectable
2j2pF-1aowA:
undetectable		 2j2pE-1aowA:
21.45
2j2pF-1aowA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFH_A_CL6A1414_1
(ERYTHROMYCIN B/D
C-12 HYDROXYLASE)		 1aow ANNEXIN IV
(Bos
taurus) 		4 / 8 LEU A  22
ILE A  36
LEU A  40
LEU A  63
 None
 0.70A 2xfhA-1aowA:
0.0		 2xfhA-1aowA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZM_A_SAMA401_0
(UNCHARACTERIZED
PROTEIN MJ0883)		 1aow ANNEXIN IV
(Bos
taurus) 		5 / 12 LEU A 193
GLY A 157
ILE A 123
ASN A 124
ASP A  90
 None
 1.15A 2zzmA-1aowA:
0.0		 2zzmA-1aowA:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZN_A_SAMA401_0
(UNCHARACTERIZED
PROTEIN MJ0883)		 1aow ANNEXIN IV
(Bos
taurus) 		5 / 12 LEU A 193
GLY A 157
ILE A 123
ASN A 124
ASP A  90
 None
 1.27A 2zznA-1aowA:
0.0		 2zznA-1aowA:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNW_A_T3A501_2
(THYROID HORMONE
RECEPTOR ALPHA)		 1aow ANNEXIN IV
(Bos
taurus) 		3 / 3 ILE A 123
MET A  98
ARG A  95
 None
 0.92A 4lnwA-1aowA:
0.0		 4lnwA-1aowA:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNX_A_T3A502_2
(THYROID HORMONE
RECEPTOR ALPHA)		 1aow ANNEXIN IV
(Bos
taurus) 		3 / 3 ILE A 123
MET A  98
ARG A  95
 None
 0.94A 4lnxA-1aowA:
0.0		 4lnxA-1aowA:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_A_SORA1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 1aow ANNEXIN IV
(Bos
taurus) 		4 / 7 ILE A 120
GLU A 161
GLY A 158
GLY A 157
 None
 0.71A 5a06A-1aowA:
undetectable		 5a06A-1aowA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_B_SORB1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 1aow ANNEXIN IV
(Bos
taurus) 		4 / 7 ILE A 120
GLU A 161
GLY A 158
GLY A 157
 None
 0.72A 5a06B-1aowA:
undetectable		 5a06B-1aowA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_C_SORC1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 1aow ANNEXIN IV
(Bos
taurus) 		4 / 7 ILE A 120
GLU A 161
GLY A 158
GLY A 157
 None
 0.73A 5a06C-1aowA:
undetectable		 5a06C-1aowA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_E_SORE1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 1aow ANNEXIN IV
(Bos
taurus) 		4 / 7 ILE A 120
GLU A 161
GLY A 158
GLY A 157
 None
 0.72A 5a06E-1aowA:
undetectable		 5a06E-1aowA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_F_SORF1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 1aow ANNEXIN IV
(Bos
taurus) 		4 / 7 ILE A 120
GLU A 161
GLY A 158
GLY A 157
 None
 0.69A 5a06F-1aowA:
undetectable		 5a06F-1aowA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E5J_A_017A201_3
(PROTEASE)		 1aow ANNEXIN IV
(Bos
taurus) 		3 / 3 ASP A 138
VAL A  94
LEU A 108
 None
 0.68A 5e5jB-1aowA:
undetectable		 5e5jB-1aowA:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FPD_B_PZAB1385_0
(HEAT SHOCK-RELATED
70KDA PROTEIN 2)		 1aow ANNEXIN IV
(Bos
taurus) 		4 / 7 VAL A 152
SER A 153
ALA A 156
ARG A 140
 None
 0.92A 5fpdB-1aowA:
undetectable		 5fpdB-1aowA:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_A_SAMA301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 1aow ANNEXIN IV
(Bos
taurus) 		5 / 12 ASP A 218
GLY A 181
THR A 187
GLU A 226
SER A 222
 None
 1.14A 5hfjA-1aowA:
undetectable		 5hfjA-1aowA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_D_SAMD301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 1aow ANNEXIN IV
(Bos
taurus) 		5 / 12 ASP A 218
GLY A 181
THR A 187
GLU A 226
SER A 222
 None
 1.15A 5hfjD-1aowA:
undetectable		 5hfjD-1aowA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_E_SAME301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 1aow ANNEXIN IV
(Bos
taurus) 		5 / 12 ASP A 218
GLY A 181
THR A 187
GLU A 226
SER A 222
 None
 1.12A 5hfjE-1aowA:
undetectable		 5hfjE-1aowA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND2_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 1aow ANNEXIN IV
(Bos
taurus) 		5 / 12 GLU A 276
ALA A  46
SER A  44
ARG A 122
ARG A  48
 None
 1.33A 5nd2B-1aowA:
undetectable		 5nd2B-1aowA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC0_A_RITA602_1
(CYTOCHROME P450 3A4)		 1aow ANNEXIN IV
(Bos
taurus) 		5 / 12 ASP A 218
ARG A 243
LEU A 253
ILE A 109
ALA A 234
 None
 1.14A 5vc0A-1aowA:
0.0		 5vc0A-1aowA:
20.86