SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ap2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3FI0_I_TRPI1001_0 (TRYPTOPHANYL-TRNA SYNTHETASE)	1ap2	MONOCLONAL ANTIBODY C219 (Mus musculus)	4 / 8	GLY A 16 ILE A 81 VAL A 19 VAL A 13	None	0.75A	3fi0I-1ap2A: undetectable	3fi0I-1ap2A: 17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3KEE_B_30BB500_2 (GENOME POLYPROTEIN)	1ap2	MONOCLONAL ANTIBODY C219 (Mus musculus)	3 / 3	PHE A 77 TYR A 98 LEU A 53	None	0.70A	3keeB-1ap2A: undetectable	3keeB-1ap2A: 21.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3LS4_H_TCIH220_2 (HEAVY CHAIN OF ANTIBODY FAB FRAGMENT LIGHT CHAIN OF ANTIBODY FAB FRAGMENT)	1ap2	MONOCLONAL ANTIBODY C219 (Mus musculus)	4 / 5	TYR A 42 GLN A 95 LEU A 102 PHE A 104	None	0.55A	3ls4L-1ap2A: 20.4	3ls4L-1ap2A: 51.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3SUE_B_SUEB1201_2 (NS3 PROTEASE, NS4A PROTEIN)	1ap2	MONOCLONAL ANTIBODY C219 (Mus musculus)	3 / 3	PHE A 77 TYR A 98 LEU A 53	None	0.79A	3sueB-1ap2A: undetectable	3sueB-1ap2A: 19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4AE1_A_NCAA1536_0 (DIPHTHERIA TOXIN)	1ap2	MONOCLONAL ANTIBODY C219 (Mus musculus)	4 / 6	GLY A 105 TYR A 92 ALA A 106 TYR A 93	None	1.00A	4ae1A-1ap2A: 3.4	4ae1A-1ap2A: 11.65

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["3FI0_I_TRPI1001_0","TRYPTOPHANYL-TRNA SYNTHETASE","1ap2","MONOCLONAL ANTIBODY C219","Mus musculus",4,"GLY A  16;ILE A  81;VAL A  19;VAL A  13","None","0.75A","3fi0I-1ap2A:undetectable","3fi0I-1ap2A:17.24"],["3KEE_B_30BB500_2","GENOME POLYPROTEIN","1ap2","MONOCLONAL ANTIBODY C219","Mus musculus",3,"PHE A  77;TYR A  98;LEU A  53","None","0.70A","3keeB-1ap2A:undetectable","3keeB-1ap2A:21.05"],["3LS4_H_TCIH220_2","HEAVY CHAIN OF ANTIBODY FAB FRAGMENT;LIGHT CHAIN OF ANTIBODY FAB FRAGMENT","1ap2","MONOCLONAL ANTIBODY C219","Mus musculus",4,"TYR A  42;GLN A  95;LEU A 102;PHE A 104","None","0.55A","3ls4L-1ap2A:20.4","3ls4L-1ap2A:51.49"],["3SUE_B_SUEB1201_2","NS3 PROTEASE, NS4A PROTEIN","1ap2","MONOCLONAL ANTIBODY C219","Mus musculus",3,"PHE A  77;TYR A  98;LEU A  53","None","0.79A","3sueB-1ap2A:undetectable","3sueB-1ap2A:19.10"],["4AE1_A_NCAA1536_0","DIPHTHERIA TOXIN","1ap2","MONOCLONAL ANTIBODY C219","Mus musculus",4,"GLY A 105;TYR A  92;ALA A 106;TYR A  93","None","1.00A","4ae1A-1ap2A:3.4","4ae1A-1ap2A:11.65"]]