SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ap8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQE_A_DVAA8_0
(MINI-GRAMICIDIN A)		 1ap8 TRANSLATION
INITIATION FACTOR
EIF4E
(Saccharomyces
cerevisiae) 		4 / 5 VAL A 153
TRP A  58
ALA A 164
TRP A 104
 None
M7G  A 214 (-2.9A)
None
M7G  A 214 (-3.1A)
 1.39A 1kqeA-1ap8A:
undetectable
1kqeE-1ap8A:
undetectable		 1kqeA-1ap8A:
8.55
1kqeE-1ap8A:
8.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOI_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 1ap8 TRANSLATION
INITIATION FACTOR
EIF4E
(Saccharomyces
cerevisiae) 		4 / 5 ASP A 145
GLY A 179
VAL A 152
ILE A 149
 None
 0.84A 2aoiA-1ap8A:
undetectable		 2aoiA-1ap8A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O9M_A_BEZA999_0
(CHOLINESTERASE)		 1ap8 TRANSLATION
INITIATION FACTOR
EIF4E
(Saccharomyces
cerevisiae) 		4 / 7 GLY A 112
GLY A 113
TRP A 115
LEU A 165
 None
 0.69A 3o9mA-1ap8A:
undetectable		 3o9mA-1ap8A:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O9M_B_BEZB999_0
(CHOLINESTERASE)		 1ap8 TRANSLATION
INITIATION FACTOR
EIF4E
(Saccharomyces
cerevisiae) 		4 / 6 GLY A 112
GLY A 113
TRP A 115
LEU A 165
 None
 0.70A 3o9mB-1ap8A:
undetectable		 3o9mB-1ap8A:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_B_SAMB301_1
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 1ap8 TRANSLATION
INITIATION FACTOR
EIF4E
(Saccharomyces
cerevisiae) 		4 / 5 GLN A 118
SER A 116
ASP A  92
ASP A  53
 None
None
M7G  A 214 (-3.6A)
M7G  A 214 ( 4.9A)
 1.33A 4qtuB-1ap8A:
undetectable		 4qtuB-1ap8A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_D_SAMD301_1
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 1ap8 TRANSLATION
INITIATION FACTOR
EIF4E
(Saccharomyces
cerevisiae) 		4 / 5 GLN A 118
SER A 116
ASP A  92
ASP A  53
 None
None
M7G  A 214 (-3.6A)
M7G  A 214 ( 4.9A)
 1.29A 4qtuD-1ap8A:
undetectable		 4qtuD-1ap8A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCK_A_SAMA2409_1
(RNA-DIRECTED RNA
POLYMERASE L)		 1ap8 TRANSLATION
INITIATION FACTOR
EIF4E
(Saccharomyces
cerevisiae) 		3 / 3 SER A 210
ASP A  99
ASP A 171
 None
 0.81A 4uckA-1ap8A:
undetectable		 4uckA-1ap8A:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VIM_A_SAMA301_1
(METHYLTRANSFERASE)		 1ap8 TRANSLATION
INITIATION FACTOR
EIF4E
(Saccharomyces
cerevisiae) 		4 / 4 SER A 210
THR A 167
ASP A  99
ASP A 171
 None
 1.20A 5vimA-1ap8A:
undetectable		 5vimA-1ap8A:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VIM_B_SAMB301_1
(METHYLTRANSFERASE)		 1ap8 TRANSLATION
INITIATION FACTOR
EIF4E
(Saccharomyces
cerevisiae) 		4 / 4 SER A 210
THR A 167
ASP A  99
ASP A 171
 None
 1.16A 5vimB-1ap8A:
undetectable		 5vimB-1ap8A:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_D_AM2D301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 1ap8 TRANSLATION
INITIATION FACTOR
EIF4E
(Saccharomyces
cerevisiae) 		4 / 8 ASP A  92
HIS A  94
GLU A  83
ASP A 127
 M7G  A 214 (-3.6A)
M7G  A 214 ( 4.1A)
None
None
 1.10A 6mn4D-1ap8A:
undetectable		 6mn4D-1ap8A:
23.62