SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1apa'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IG3_B_VIBB501_1
(THIAMIN
PYROPHOSPHOKINASE)		 1apa POKEWEED ANTIVIRAL
PROTEIN
(Phytolacca
americana) 		4 / 7 ASP A 252
LEU A 231
SER A 211
ASN A 207
 None
 1.16A 1ig3A-1apaA:
undetectable
1ig3B-1apaA:
undetectable		 1ig3A-1apaA:
20.96
1ig3B-1apaA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRG_A_ADNA300_1
(ALPHA-MOMORCHARIN)		 1apa POKEWEED ANTIVIRAL
PROTEIN
(Phytolacca
americana) 		5 / 9 PHE A  94
TYR A 128
ILE A 175
GLU A 180
ARG A 183
 None
 0.51A 1mrgA-1apaA:
30.6		 1mrgA-1apaA:
29.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRJ_A_ADNA300_1
(ALPHA-TRICHOSANTHIN)		 1apa POKEWEED ANTIVIRAL
PROTEIN
(Phytolacca
americana) 		5 / 8 TYR A 128
ILE A 175
SER A 179
GLU A 180
ARG A 183
 None
 0.48A 1mrjA-1apaA:
30.2		 1mrjA-1apaA:
28.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_E_URFE2031_1
(URIDINE
PHOSPHORYLASE)		 1apa POKEWEED ANTIVIRAL
PROTEIN
(Phytolacca
americana) 		4 / 8 THR A 228
GLY A 225
GLN A 264
VAL A 246
 None
 0.99A 1rxcE-1apaA:
undetectable		 1rxcE-1apaA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUJ_A_CAMA422_0
(CAMPHOR
5-MONOOXYGENASE)		 1apa POKEWEED ANTIVIRAL
PROTEIN
(Phytolacca
americana) 		4 / 8 LEU A  69
VAL A  57
VAL A  13
LEU A 149
 None
 0.88A 2zujA-1apaA:
0.0		 2zujA-1apaA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_B_ERYB195_0
(REPRESSOR PROTEIN
MPHR(A))		 1apa POKEWEED ANTIVIRAL
PROTEIN
(Phytolacca
americana) 		5 / 12 LEU A  76
GLY A 254
ILE A  28
SER A  27
ILE A  18
 None
 0.97A 3frqB-1apaA:
0.0		 3frqB-1apaA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_C_URFC1301_1
(URIDINE
PHOSPHORYLASE)		 1apa POKEWEED ANTIVIRAL
PROTEIN
(Phytolacca
americana) 		4 / 8 THR A 228
GLY A 225
GLN A 264
VAL A 246
 None
 0.98A 4e1vC-1apaA:
undetectable		 4e1vC-1apaA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_D_URFD1301_1
(URIDINE
PHOSPHORYLASE)		 1apa POKEWEED ANTIVIRAL
PROTEIN
(Phytolacca
americana) 		4 / 8 THR A 228
GLY A 225
GLN A 264
VAL A 246
 None
 1.00A 4e1vD-1apaA:
undetectable		 4e1vD-1apaA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_G_URFG1301_1
(URIDINE
PHOSPHORYLASE)		 1apa POKEWEED ANTIVIRAL
PROTEIN
(Phytolacca
americana) 		4 / 8 THR A 228
GLY A 225
GLN A 264
VAL A 246
 None
 0.98A 4e1vG-1apaA:
undetectable		 4e1vG-1apaA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O0O_A_URFA303_1
(RRNA N-GLYCOSIDASE)		 1apa POKEWEED ANTIVIRAL
PROTEIN
(Phytolacca
americana) 		4 / 5 TYR A  77
TYR A 128
ILE A 175
ARG A 183
 None
 0.50A 4o0oA-1apaA:
30.8		 4o0oA-1apaA:
29.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YP2_B_NCAB302_0
(RIBOSOME-INACTIVATIN
G PROTEIN MOMORDIN I)		 1apa POKEWEED ANTIVIRAL
PROTEIN
(Phytolacca
americana) 		6 / 9 TYR A  77
PHE A  94
TYR A 128
ILE A 175
GLU A 180
ARG A 183
 None
 0.65A 4yp2B-1apaA:
30.7		 4yp2B-1apaA:
30.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5CF9_B_NCAB302_0
(RIBOSOME-INACTIVATIN
G PROTEIN MOMORDIN I)		 1apa POKEWEED ANTIVIRAL
PROTEIN
(Phytolacca
americana) 		6 / 9 TYR A  77
PHE A  94
TYR A 128
ILE A 175
GLU A 180
ARG A 183
 None
 0.64A 5cf9B-1apaA:
30.9		 5cf9B-1apaA:
30.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Q1S_A_AWYA1103_0
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 1apa POKEWEED ANTIVIRAL
PROTEIN
(Phytolacca
americana) 		4 / 6 VAL A 106
ILE A  97
LYS A  72
TYR A  54
 None
 1.43A 5q1sA-1apaA:
0.0		 5q1sA-1apaA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_C_SAMC601_0
(NS5
METHYLTRANSFERASE)		 1apa POKEWEED ANTIVIRAL
PROTEIN
(Phytolacca
americana) 		5 / 12 GLY A  80
THR A  58
ASP A  12
VAL A  13
ILE A 153
 None
 1.03A 5wz1C-1apaA:
undetectable		 5wz1C-1apaA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_E_SAME601_0
(NS5
METHYLTRANSFERASE)		 1apa POKEWEED ANTIVIRAL
PROTEIN
(Phytolacca
americana) 		5 / 12 GLY A  80
THR A  58
ASP A  12
VAL A  13
ILE A 153
 None
 1.03A 5wz1E-1apaA:
undetectable		 5wz1E-1apaA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z3J_A_NCAA302_0
(ABRIN A-CHAIN)		 1apa POKEWEED ANTIVIRAL
PROTEIN
(Phytolacca
americana) 		6 / 6 TYR A  77
VAL A  78
TYR A 128
ILE A 175
GLU A 180
ARG A 183
 None
 0.64A 5z3jA-1apaA:
32.1		 5z3jA-1apaA:
27.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CB4_A_BEZA501_0
(CANAVALIN)		 1apa POKEWEED ANTIVIRAL
PROTEIN
(Phytolacca
americana) 		4 / 8 LEU A  76
VAL A  57
LEU A  55
ILE A   9
 None
 0.85A 6cb4A-1apaA:
undetectable		 6cb4A-1apaA:
22.49