SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1apy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DVX_B_DIFB125_1
(TRANSTHYRETIN)		 1apy ASPARTYLGLUCOSAMINID
ASE
(Homo
sapiens) 		4 / 7 LEU A  82
ALA A  66
LEU A  64
SER A  55
 None
 1.06A 1dvxA-1apyA:
undetectable		 1dvxA-1apyA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q8J_B_C2FB802_0
(5-METHYLTETRAHYDROFO
LATE S-HOMOCYSTEINE
METHYLTRANSFERASE)		 1apy ASPARTYLGLUCOSAMINID
ASE
ASPARTYLGLUCOSAMINID
ASE
(Homo
sapiens;
Homo
sapiens) 		5 / 12 ASN B 285
GLY B 256
SER A   2
GLY B 193
ILE B 189
 NAG  B 511 (-1.9A)
NAG  B 511 ( 4.3A)
None
None
None
 1.01A 1q8jB-1apyB:
undetectable		 1q8jB-1apyB:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_B_PAUB248_0
(TYPE III
PANTOTHENATE KINASE)		 1apy ASPARTYLGLUCOSAMINID
ASE
(Homo
sapiens) 		5 / 12 ASN B 236
VAL B 212
GLY B 213
ASP B 214
THR B 201
 None
 1.15A 3bf1A-1apyB:
undetectable
3bf1B-1apyB:
undetectable		 3bf1A-1apyB:
20.39
3bf1B-1apyB:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BUF_A_AEGA394_0
(BETA-SECRETASE 1)		 1apy ASPARTYLGLUCOSAMINID
ASE
(Homo
sapiens) 		4 / 5 LEU B 240
ILE B 267
ILE B 239
GLY B 235
 None
 0.86A 3bufA-1apyB:
undetectable		 3bufA-1apyB:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_D_SUED1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 1apy ASPARTYLGLUCOSAMINID
ASE
(Homo
sapiens) 		5 / 12 GLY B 213
VAL A  79
ALA B 220
ALA B 222
ALA B 231
 None
 0.91A 3sudD-1apyB:
undetectable		 3sudD-1apyB:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_B_DXCB1473_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 1apy ASPARTYLGLUCOSAMINID
ASE
ASPARTYLGLUCOSAMINID
ASE
(Homo
sapiens;
Homo
sapiens) 		4 / 8 GLY A 117
PHE A 118
VAL A  79
SER B 200
 None
 0.91A 4acbB-1apyA:
undetectable
4acbC-1apyA:
undetectable		 4acbB-1apyA:
17.62
4acbC-1apyA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RFQ_A_SAMA401_1
(HISTIDINE PROTEIN
METHYLTRANSFERASE 1
HOMOLOG)		 1apy ASPARTYLGLUCOSAMINID
ASE
(Homo
sapiens) 		4 / 4 THR B 201
GLY B 237
ASP B 238
SER B 215
 None
 1.11A 4rfqA-1apyB:
undetectable		 4rfqA-1apyB:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RYA_A_MTLA501_0
(ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (SORBITOL))		 1apy ASPARTYLGLUCOSAMINID
ASE
(Homo
sapiens) 		5 / 12 GLY B 185
ALA B 232
PHE B 305
ALA B 292
VAL B 320
 None
 1.11A 4ryaA-1apyB:
undetectable		 4ryaA-1apyB:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DWK_C_ACTC207_0
(DIACYLGLYCEROL
KINASE)		 1apy ASPARTYLGLUCOSAMINID
ASE
(Homo
sapiens) 		4 / 5 ALA A  66
GLU A  42
ASN A  87
GLU A  35
 None
 1.49A 5dwkC-1apyA:
undetectable		 5dwkC-1apyA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G5G_A_ACTA1231_0
(PUTATIVE XANTHINE
DEHYDROGENASE YAGR
MOLYBDENUM-BINDING
SU SUBUNIT
PUTATIVE XANTHINE
DEHYDROGENASE YAGT
IRON-SULFUR-BINDING
SUBUNIT)		 1apy ASPARTYLGLUCOSAMINID
ASE
ASPARTYLGLUCOSAMINID
ASE
(Homo
sapiens;
Homo
sapiens) 		3 / 3 ARG B 211
THR B 201
ASP A  65
 None
 0.94A 5g5gA-1apyB:
0.0
5g5gB-1apyB:
0.0		 5g5gA-1apyB:
19.37
5g5gB-1apyB:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A7P_A_9SCA601_1
(SERUM ALBUMIN)		 1apy ASPARTYLGLUCOSAMINID
ASE
ASPARTYLGLUCOSAMINID
ASE
(Homo
sapiens;
Homo
sapiens) 		4 / 5 ASN B 202
VAL A 105
LEU A 103
SER B 215
 None
 1.32A 6a7pA-1apyB:
undetectable		 6a7pA-1apyB:
11.97