SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1aqz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U1J_A_C2FA773_0
(5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE)		 1aqz RESTRICTOCIN
(Aspergillus
restrictus) 		4 / 8 ARG A 120
HIS A  34
SER A  33
VAL A 121
 PO4  A 400 ( 3.8A)
None
None
None
 1.19A 1u1jA-1aqzA:
undetectable		 1u1jA-1aqzA:
11.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_B_SAMB300_1
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 1aqz RESTRICTOCIN
(Aspergillus
restrictus) 		4 / 5 SER A  39
GLY A  41
HIS A  35
ASP A 108
 None
 1.11A 2oxtB-1aqzA:
undetectable		 2oxtB-1aqzA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SU9_A_ACTA426_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 1aqz RESTRICTOCIN
(Aspergillus
restrictus) 		3 / 3 GLN A   8
GLU A  18
LYS A  18
 None
 1.19A 3su9A-1aqzA:
undetectable		 3su9A-1aqzA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_D_SUED1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 1aqz RESTRICTOCIN
(Aspergillus
restrictus) 		3 / 3 TYR A 125
LEU A  61
LYS A  60
 None
 0.61A 3sueD-1aqzA:
undetectable		 3sueD-1aqzA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T8N_D_EDTD135_0
(STEROID
DELTA-ISOMERASE)		 1aqz RESTRICTOCIN
(Aspergillus
restrictus) 		5 / 11 GLY A 117
PRO A 118
PRO A 116
THR A  98
PRO A  97
 None
 1.48A 3t8nD-1aqzA:
0.0
3t8nF-1aqzA:
0.2		 3t8nD-1aqzA:
22.15
3t8nF-1aqzA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T8N_D_EDTD135_0
(STEROID
DELTA-ISOMERASE)		 1aqz RESTRICTOCIN
(Aspergillus
restrictus) 		5 / 11 THR A  98
PRO A  97
GLY A 117
PRO A 118
PRO A 116
 None
 1.48A 3t8nD-1aqzA:
0.0
3t8nF-1aqzA:
0.2		 3t8nD-1aqzA:
22.15
3t8nF-1aqzA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_A_ACRA609_0
(ALPHA-AMYLASE)		 1aqz RESTRICTOCIN
(Aspergillus
restrictus) 		4 / 7 GLY A  41
ASP A  90
TRP A  50
MET A  86
 None
 1.27A 6ag0A-1aqzA:
undetectable		 6ag0A-1aqzA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC609_0
(ALPHA-AMYLASE)		 1aqz RESTRICTOCIN
(Aspergillus
restrictus) 		4 / 7 GLY A  41
ASP A  90
TRP A  50
MET A  86
 None
 1.26A 6ag0C-1aqzA:
undetectable		 6ag0C-1aqzA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_A_STIA604_1
(TYROSINE-PROTEIN
KINASE ABL1)		 1aqz RESTRICTOCIN
(Aspergillus
restrictus) 		4 / 5 TYR A  47
VAL A 129
PHE A  99
GLY A 117
 PO4  A 400 (-4.4A)
None
None
None
 1.36A 6hd4A-1aqzA:
undetectable		 6hd4A-1aqzA:
19.59