SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ar1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_A_FFOA1293_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 1ar1 CYTOCHROME C OXIDASE
(Paracoccus
denitrificans) 		3 / 3 GLU B 153
TYR B 149
PHE B 213
 None
 0.54A 1eqbB-1ar1B:
undetectable		 1eqbB-1ar1B:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_B_FFOB2293_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 1ar1 CYTOCHROME C OXIDASE
(Paracoccus
denitrificans) 		3 / 3 GLU B 153
TYR B 149
PHE B 213
 None
 0.54A 1eqbA-1ar1B:
undetectable		 1eqbA-1ar1B:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_C_FFOC3293_2
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 1ar1 CYTOCHROME C OXIDASE
(Paracoccus
denitrificans) 		3 / 3 GLU B 153
TYR B 149
PHE B 213
 None
 0.54A 1eqbD-1ar1B:
undetectable		 1eqbD-1ar1B:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_D_FFOD4293_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 1ar1 CYTOCHROME C OXIDASE
(Paracoccus
denitrificans) 		3 / 3 GLU B 153
TYR B 149
PHE B 213
 None
 0.55A 1eqbC-1ar1B:
undetectable		 1eqbC-1ar1B:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IWK_A_CUA1598_0
(NITROUS OXIDE
REDUCTASE)		 1ar1 CYTOCHROME C OXIDASE
(Paracoccus
denitrificans) 		4 / 4 HIS B 181
CYH B 216
CYH B 220
MET B 227
 CU  B 271 ( 3.2A)
CU  B 271 (-2.2A)
CU  B 270 (-2.1A)
CU  B 271 ( 2.5A)
 0.51A 2iwkA-1ar1B:
9.6		 2iwkA-1ar1B:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IWK_A_CUA1599_0
(NITROUS OXIDE
REDUCTASE)		 1ar1 CYTOCHROME C OXIDASE
(Paracoccus
denitrificans) 		3 / 3 CYH B 216
CYH B 220
HIS B 224
 CU  B 271 (-2.2A)
CU  B 270 (-2.1A)
CU  B 270 ( 3.2A)
 0.34A 2iwkA-1ar1B:
9.6		 2iwkA-1ar1B:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IWK_B_CUB1598_0
(NITROUS OXIDE
REDUCTASE)		 1ar1 CYTOCHROME C OXIDASE
(Paracoccus
denitrificans) 		4 / 4 HIS B 181
CYH B 216
CYH B 220
MET B 227
 CU  B 271 ( 3.2A)
CU  B 271 (-2.2A)
CU  B 270 (-2.1A)
CU  B 271 ( 2.5A)
 0.51A 2iwkB-1ar1B:
9.7		 2iwkB-1ar1B:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IWK_B_CUB1599_0
(NITROUS OXIDE
REDUCTASE)		 1ar1 CYTOCHROME C OXIDASE
(Paracoccus
denitrificans) 		3 / 3 CYH B 216
CYH B 220
HIS B 224
 CU  B 271 (-2.2A)
CU  B 270 (-2.1A)
CU  B 270 ( 3.2A)
 0.32A 2iwkB-1ar1B:
9.7		 2iwkB-1ar1B:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9C_C_ACTC1120_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 1ar1 CYTOCHROME C OXIDASE
(Paracoccus
denitrificans) 		3 / 3 LYS B 232
TYR B 149
PRO B 161
 None
 1.48A 2j9cC-1ar1B:
0.0		 2j9cC-1ar1B:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCT_B_ASDB1223_1
(GLUTATHIONE
S-TRANSFERASE A2)		 1ar1 CYTOCHROME C OXIDASE
(Paracoccus
denitrificans) 		4 / 8 ILE B  92
GLY B  93
LEU B  97
LEU B 100
 None
LDA  B 274 ( 4.4A)
LDA  B 274 ( 4.4A)
None
 0.87A 2vctB-1ar1B:
0.0		 2vctB-1ar1B:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X0Y_A_X0TA1625_1
(O-GLCNACASE NAGJ)		 1ar1 CYTOCHROME C OXIDASE
(Paracoccus
denitrificans) 		5 / 12 ASP B 130
VAL B 132
TYR B 127
VAL B 163
VAL B   3
 None
 1.46A 2x0yA-1ar1B:
undetectable		 2x0yA-1ar1B:
18.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3DTU_B_CUB1004_0
(CYTOCHROME C OXIDASE
SUBUNIT 2)		 1ar1 CYTOCHROME C OXIDASE
(Paracoccus
denitrificans) 		4 / 4 HIS B 181
CYH B 216
CYH B 220
MET B 227
 CU  B 271 ( 3.2A)
CU  B 271 (-2.2A)
CU  B 270 (-2.1A)
CU  B 271 ( 2.5A)
 0.20A 3dtuB-1ar1B:
30.6		 3dtuB-1ar1B:
48.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3DTU_B_CUB1022_0
(CYTOCHROME C OXIDASE
SUBUNIT 2)		 1ar1 CYTOCHROME C OXIDASE
(Paracoccus
denitrificans) 		3 / 3 CYH B 216
CYH B 220
HIS B 224
 CU  B 271 (-2.2A)
CU  B 270 (-2.1A)
CU  B 270 ( 3.2A)
 0.19A 3dtuB-1ar1B:
30.6		 3dtuB-1ar1B:
48.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3DTU_D_CUD3_0
(CYTOCHROME C OXIDASE
SUBUNIT 2)		 1ar1 CYTOCHROME C OXIDASE
(Paracoccus
denitrificans) 		3 / 3 CYH B 216
CYH B 220
HIS B 224
 CU  B 271 (-2.2A)
CU  B 270 (-2.1A)
CU  B 270 ( 3.2A)
 0.19A 3dtuD-1ar1B:
30.7		 3dtuD-1ar1B:
48.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3DTU_D_CUD4_0
(CYTOCHROME C OXIDASE
SUBUNIT 2)		 1ar1 CYTOCHROME C OXIDASE
(Paracoccus
denitrificans) 		4 / 4 HIS B 181
CYH B 216
CYH B 220
MET B 227
 CU  B 271 ( 3.2A)
CU  B 271 (-2.2A)
CU  B 270 (-2.1A)
CU  B 271 ( 2.5A)
 0.25A 3dtuD-1ar1B:
30.7		 3dtuD-1ar1B:
48.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RV5_D_DXCD92_0
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 1ar1 CYTOCHROME C OXIDASE
(Paracoccus
denitrificans) 		4 / 5 VAL B 231
GLU B 240
LYS B 168
PHE B 188
 None
 1.49A 3rv5C-1ar1B:
undetectable
3rv5D-1ar1B:
undetectable		 3rv5C-1ar1B:
14.34
3rv5D-1ar1B:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EM2_A_SALA502_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR SAR2349)		 1ar1 CYTOCHROME C OXIDASE
(Paracoccus
denitrificans) 		4 / 8 LEU B   4
TRP B 242
VAL B 163
GLN B 236
 None
 1.01A 4em2A-1ar1B:
undetectable		 4em2A-1ar1B:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YFB_C_PACC601_0
(PROTEIN RELATED TO
PENICILLIN ACYLASE)		 1ar1 CYTOCHROME C OXIDASE
(Paracoccus
denitrificans) 		5 / 12 PHE B 188
PHE B 204
VAL B 163
TRP B 183
VAL B 162
 None
 1.31A 4yfbC-1ar1B:
0.0		 4yfbC-1ar1B:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YFB_F_PACF601_0
(PROTEIN RELATED TO
PENICILLIN ACYLASE)		 1ar1 CYTOCHROME C OXIDASE
(Paracoccus
denitrificans) 		5 / 12 PHE B 188
PHE B 204
VAL B 163
TRP B 183
VAL B 162
 None
 1.32A 4yfbF-1ar1B:
0.0		 4yfbF-1ar1B:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YFB_I_PACI601_0
(PROTEIN RELATED TO
PENICILLIN ACYLASE)		 1ar1 CYTOCHROME C OXIDASE
(Paracoccus
denitrificans) 		5 / 12 PHE B 188
PHE B 204
VAL B 163
TRP B 183
VAL B 162
 None
 1.32A 4yfbI-1ar1B:
0.0		 4yfbI-1ar1B:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YFB_L_PACL601_0
(PROTEIN RELATED TO
PENICILLIN ACYLASE)		 1ar1 CYTOCHROME C OXIDASE
(Paracoccus
denitrificans) 		5 / 12 PHE B 188
PHE B 204
VAL B 163
TRP B 183
VAL B 162
 None
 1.30A 4yfbL-1ar1B:
0.0		 4yfbL-1ar1B:
19.79