SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1arl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_A_9CRA165_2
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 1arl APO-CARBOXYPEPTIDASE
A=ALPHA= (COX)
(Bos
taurus) 		4 / 7 LEU A 107
PHE A  86
VAL A  33
TYR A   9
 None
 0.66A 1epbA-1arlA:
undetectable		 1epbA-1arlA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_B_9CRB165_2
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 1arl APO-CARBOXYPEPTIDASE
A=ALPHA= (COX)
(Bos
taurus) 		4 / 8 LEU A 107
PHE A  86
VAL A  33
TYR A   9
 None
 0.78A 1epbB-1arlA:
0.0		 1epbB-1arlA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WG8_B_SAMB3141_1
(PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 1arl APO-CARBOXYPEPTIDASE
A=ALPHA= (COX)
(Bos
taurus) 		3 / 3 HIS A 166
ASP A 148
ASN A 260
 None
 0.71A 1wg8B-1arlA:
undetectable		 1wg8B-1arlA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GL0_C_ADNC903_1
(CONSERVED
HYPOTHETICAL PROTEIN)		 1arl APO-CARBOXYPEPTIDASE
A=ALPHA= (COX)
(Bos
taurus) 		5 / 12 ALA A 143
ASN A 144
VAL A  49
SER A 254
HIS A 196
 None
 0.99A 2gl0A-1arlA:
0.0
2gl0C-1arlA:
0.0		 2gl0A-1arlA:
16.39
2gl0C-1arlA:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GL0_D_ADND904_1
(CONSERVED
HYPOTHETICAL PROTEIN)		 1arl APO-CARBOXYPEPTIDASE
A=ALPHA= (COX)
(Bos
taurus) 		5 / 12 SER A 254
HIS A 196
ALA A 143
ASN A 144
VAL A  49
 None
 1.01A 2gl0D-1arlA:
0.0
2gl0E-1arlA:
0.0		 2gl0D-1arlA:
16.39
2gl0E-1arlA:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_A_SC2A1290_1
(FICOLIN-2)		 1arl APO-CARBOXYPEPTIDASE
A=ALPHA= (COX)
(Bos
taurus) 		4 / 5 SER A 197
LEU A 280
GLY A 278
ARG A 124
 None
 0.90A 2j2pA-1arlA:
0.0
2j2pB-1arlA:
undetectable		 2j2pA-1arlA:
24.04
2j2pB-1arlA:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_C_SC2C1289_1
(FICOLIN-2)		 1arl APO-CARBOXYPEPTIDASE
A=ALPHA= (COX)
(Bos
taurus) 		4 / 6 ARG A 124
SER A 197
LEU A 280
GLY A 278
 None
 0.96A 2j2pA-1arlA:
0.0
2j2pC-1arlA:
0.0		 2j2pA-1arlA:
24.04
2j2pC-1arlA:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_F_SC2F1289_1
(FICOLIN-2)		 1arl APO-CARBOXYPEPTIDASE
A=ALPHA= (COX)
(Bos
taurus) 		4 / 6 ARG A 124
SER A 197
LEU A 280
GLY A 278
 None
 0.94A 2j2pD-1arlA:
0.0
2j2pF-1arlA:
0.0		 2j2pD-1arlA:
24.04
2j2pF-1arlA:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_B_QPSB1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 1arl APO-CARBOXYPEPTIDASE
A=ALPHA= (COX)
(Bos
taurus) 		5 / 10 VAL A 180
SER A 258
SER A 266
GLY A 252
ALA A 149
 None
 1.25A 2x2iB-1arlA:
0.0		 2x2iB-1arlA:
14.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_B_HSMB1162_1
(ALLERGEN ARG R 1)		 1arl APO-CARBOXYPEPTIDASE
A=ALPHA= (COX)
(Bos
taurus) 		3 / 3 GLU A 270
HIS A  69
GLU A  72
 None
 0.85A 2x45B-1arlA:
0.0		 2x45B-1arlA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1162_1
(ALLERGEN ARG R 1)		 1arl APO-CARBOXYPEPTIDASE
A=ALPHA= (COX)
(Bos
taurus) 		3 / 3 GLU A 270
HIS A  69
GLU A  72
 None
 0.88A 2x45C-1arlA:
0.0		 2x45C-1arlA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHX_A_PXLA313_1
(PYRIDOXAL KINASE)		 1arl APO-CARBOXYPEPTIDASE
A=ALPHA= (COX)
(Bos
taurus) 		4 / 4 SER A 266
HIS A 303
THR A 304
VAL A 222
 None
 1.43A 3fhxA-1arlA:
2.4		 3fhxA-1arlA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TAJ_A_NBOA700_1
(LACTOTRANSFERRIN)		 1arl APO-CARBOXYPEPTIDASE
A=ALPHA= (COX)
(Bos
taurus) 		5 / 7 THR A 129
GLY A 115
PRO A 113
ASN A 112
GLY A  44
 None
 1.00A 3tajA-1arlA:
undetectable		 3tajA-1arlA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U8Q_A_NPUA7231_1
(LACTOTRANSFERRIN)		 1arl APO-CARBOXYPEPTIDASE
A=ALPHA= (COX)
(Bos
taurus) 		4 / 5 THR A 129
GLY A 115
PRO A 113
ASN A 112
 None
 0.87A 3u8qA-1arlA:
undetectable		 3u8qA-1arlA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UGR_A_IMNA2001_2
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 1arl APO-CARBOXYPEPTIDASE
A=ALPHA= (COX)
(Bos
taurus) 		4 / 7 TYR A  12
GLU A 292
TYR A 234
TYR A 238
 None
 1.28A 3ugrA-1arlA:
undetectable		 3ugrA-1arlA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FJP_A_NPSA711_1
(LACTOTRANSFERRIN)		 1arl APO-CARBOXYPEPTIDASE
A=ALPHA= (COX)
(Bos
taurus) 		5 / 6 THR A 129
GLY A 115
PRO A 113
ASN A 112
GLY A  44
 None
 0.96A 4fjpA-1arlA:
undetectable		 4fjpA-1arlA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FU9_A_ACTA311_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 1arl APO-CARBOXYPEPTIDASE
A=ALPHA= (COX)
(Bos
taurus) 		3 / 3 GLN A 249
THR A 209
THR A 210
 None
 0.36A 4fu9A-1arlA:
0.0		 4fu9A-1arlA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FUF_A_ACTA310_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 1arl APO-CARBOXYPEPTIDASE
A=ALPHA= (COX)
(Bos
taurus) 		3 / 3 GLN A 249
THR A 209
THR A 210
 None
 0.34A 4fufA-1arlA:
0.0		 4fufA-1arlA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KJK_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1arl APO-CARBOXYPEPTIDASE
A=ALPHA= (COX)
(Bos
taurus) 		5 / 12 ILE A 105
THR A 304
ILE A 300
LEU A 193
ILE A  62
 None
 1.06A 4kjkA-1arlA:
undetectable		 4kjkA-1arlA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R82_A_ACTA205_0
(OXIDOREDUCTASE)		 1arl APO-CARBOXYPEPTIDASE
A=ALPHA= (COX)
(Bos
taurus) 		4 / 5 SER A  41
GLY A  44
ARG A  45
GLU A  43
 None
 1.25A 4r82A-1arlA:
0.0
4r82B-1arlA:
0.0		 4r82A-1arlA:
22.77
4r82B-1arlA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIO_A_HFGA801_1
(PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE))		 1arl APO-CARBOXYPEPTIDASE
A=ALPHA= (COX)
(Bos
taurus) 		3 / 3 THR A 268
GLU A 270
HIS A  69
 None
 0.79A 5xioA-1arlA:
undetectable		 5xioA-1arlA:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_B_HFGB1002_1
(PROLYL-TRNA
SYNTHETASE (PRORS))		 1arl APO-CARBOXYPEPTIDASE
A=ALPHA= (COX)
(Bos
taurus) 		3 / 3 THR A 268
GLU A 270
HIS A  69
 None
 0.81A 5xiqB-1arlA:
undetectable		 5xiqB-1arlA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_D_HFGD1002_1
(PROLYL-TRNA
SYNTHETASE (PRORS))		 1arl APO-CARBOXYPEPTIDASE
A=ALPHA= (COX)
(Bos
taurus) 		3 / 3 THR A 268
GLU A 270
HIS A  69
 None
 0.88A 5xiqD-1arlA:
undetectable		 5xiqD-1arlA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_A_ACRA602_2
(-)		 1arl APO-CARBOXYPEPTIDASE
A=ALPHA= (COX)
(Bos
taurus) 		4 / 6 TRP A  73
HIS A  69
ASN A 112
GLU A 173
 None
 1.25A 6gneA-1arlA:
3.5		 6gneA-1arlA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_B_ACRB602_2
(-)		 1arl APO-CARBOXYPEPTIDASE
A=ALPHA= (COX)
(Bos
taurus) 		4 / 8 TRP A  73
HIS A  69
ASN A 112
GLU A 173
 None
 1.23A 6gneB-1arlA:
3.4		 6gneB-1arlA:
22.05