SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1as4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D1G_A_MTXA171_1
(DIHYDROFOLATE
REDUCTASE)		 1as4 ANTICHYMOTRYPSIN
(Homo
sapiens) 		5 / 12 ALA A 352
ARG A 295
ILE A 302
LEU A  41
ILE A  57
 None
 1.06A 1d1gA-1as4A:
undetectable		 1d1gA-1as4A:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_E_THAE5_2
(LIVER
CARBOXYLESTERASE I)		 1as4 ANTICHYMOTRYPSIN
(Homo
sapiens) 		3 / 3 PHE B 383
LEU A 103
LEU A  99
 None
 0.54A 1mx1E-1as4B:
undetectable		 1mx1E-1as4B:
4.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_D_AG2D7015_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 1as4 ANTICHYMOTRYPSIN
(Homo
sapiens) 		4 / 7 LEU A  61
LEU A 299
LEU A 306
GLY A  79
 None
 0.81A 1n13D-1as4A:
0.0
1n13E-1as4A:
0.0		 1n13D-1as4A:
14.45
1n13E-1as4A:
12.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_D_SAMD301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 1as4 ANTICHYMOTRYPSIN
(Homo
sapiens) 		3 / 3 LYS A 174
ASP A  47
ASP A 296
 None
 0.92A 2br4D-1as4A:
undetectable		 2br4D-1as4A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2D55_C_DVAC2_0
(ACTINOMYCIN D)		 1as4 ANTICHYMOTRYPSIN
(Homo
sapiens) 		3 / 3 THR B 389
PRO B 391
PRO B 369
 None
 0.77A 2d55C-1as4B:
undetectable		 2d55C-1as4B:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IJ7_C_TPFC2471_1
(CYTOCHROME P450 121)		 1as4 ANTICHYMOTRYPSIN
(Homo
sapiens) 		4 / 8 VAL B 375
ASN B 381
PHE A  52
ALA A  34
 None
 1.10A 2ij7C-1as4B:
undetectable		 2ij7C-1as4B:
7.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OUZ_A_C3DA999_0
(ESTROGEN RECEPTOR)		 1as4 ANTICHYMOTRYPSIN
(Homo
sapiens) 		5 / 12 LEU A  64
LEU A  73
ILE A 308
GLY A  79
LEU A  80
 None
 0.91A 2ouzA-1as4A:
0.0		 2ouzA-1as4A:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		 1as4 ANTICHYMOTRYPSIN
(Homo
sapiens) 		3 / 3 LEU A  26
LEU A 137
PHE A  82
 None
 0.69A 2pgrA-1as4A:
undetectable		 2pgrA-1as4A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XCT_G_CPFG1020_1
(DNA GYRASE SUBUNIT
B, DNA GYRASE
SUBUNIT A)		 1as4 ANTICHYMOTRYPSIN
(Homo
sapiens) 		3 / 3 ARG A 166
GLY A 167
SER A 292
 None
 0.64A 2xctB-1as4A:
undetectable		 2xctB-1as4A:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
316D_C_DVAC2_0
(8-FLUORO-ACTINOMYCIN
D)		 1as4 ANTICHYMOTRYPSIN
(Homo
sapiens) 		3 / 3 THR B 377
PRO B 376
THR B 379
 None
 0.90A 316dC-1as4B:
undetectable		 316dC-1as4B:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_B_SVRB512_2
(PHOSPHOLIPASE A2)		 1as4 ANTICHYMOTRYPSIN
(Homo
sapiens) 		4 / 7 VAL A 183
ILE A 321
GLY A 320
ARG A 325
 None
 0.83A 3bjwB-1as4A:
0.0		 3bjwB-1as4A:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF509_3
(PHOSPHOLIPASE A2)		 1as4 ANTICHYMOTRYPSIN
(Homo
sapiens) 		4 / 7 VAL A 183
ILE A 321
GLY A 320
ARG A 325
 None
 0.91A 3bjwF-1as4A:
undetectable		 3bjwF-1as4A:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_H_SVRH511_3
(PHOSPHOLIPASE A2)		 1as4 ANTICHYMOTRYPSIN
(Homo
sapiens) 		4 / 7 VAL A 183
ILE A 321
GLY A 320
ARG A 325
 None
 0.83A 3bjwH-1as4A:
undetectable		 3bjwH-1as4A:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_B_CELB1701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1as4 ANTICHYMOTRYPSIN
(Homo
sapiens) 		4 / 6 VAL A 332
LEU A 100
ILE A  92
ALA A  60
 None
 0.92A 3kk6B-1as4A:
0.0		 3kk6B-1as4A:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L4D_B_TPFB490_1
(STEROL 14-ALPHA
DEMETHYLASE)		 1as4 ANTICHYMOTRYPSIN
(Homo
sapiens) 		5 / 9 PHE A  96
ALA A  62
ALA A  60
THR A 351
MET A 114
 None
 1.40A 3l4dB-1as4A:
undetectable		 3l4dB-1as4A:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U7S_A_017A201_2
(POL POLYPROTEIN)		 1as4 ANTICHYMOTRYPSIN
(Homo
sapiens) 		5 / 9 ALA A 347
ILE A  51
ILE B 373
PRO A  54
LEU A  55
 ACT  B 600 (-3.6A)
None
None
None
None
 1.10A 3u7sB-1as4A:
undetectable		 3u7sB-1as4A:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U7S_A_017A202_1
(POL POLYPROTEIN)		 1as4 ANTICHYMOTRYPSIN
(Homo
sapiens) 		5 / 9 ALA A 347
ILE A  51
ILE B 373
PRO A  54
LEU A  55
 ACT  B 600 (-3.6A)
None
None
None
None
 1.08A 3u7sA-1as4A:
undetectable		 3u7sA-1as4A:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQT_A_30ZA1920_1
(ANDROGEN RECEPTOR)		 1as4 ANTICHYMOTRYPSIN
(Homo
sapiens) 		4 / 6 GLY A 139
ASN A 116
LEU A 100
ASN A 104
 None
 1.02A 3zqtA-1as4A:
0.0		 3zqtA-1as4A:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4H1N_A_CGEA505_1
(CYTOCHROME P450 2B4)		 1as4 ANTICHYMOTRYPSIN
(Homo
sapiens) 		5 / 11 ILE B 374
PHE A 341
ALA A 347
ILE A  51
VAL B 388
 ACT  B 600 (-4.6A)
None
ACT  B 600 (-3.6A)
None
None
 1.05A 4h1nA-1as4B:
undetectable		 4h1nA-1as4B:
7.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KUK_A_RBFA201_1
(BLUE-LIGHT
PHOTORECEPTOR)		 1as4 ANTICHYMOTRYPSIN
(Homo
sapiens) 		5 / 12 ASN A 104
ASN B 381
ASN A  30
LEU A  55
ILE A 188
 None
 1.49A 4kukA-1as4A:
undetectable		 4kukA-1as4A:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_F_377F402_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 1as4 ANTICHYMOTRYPSIN
(Homo
sapiens) 		4 / 8 ALA A 117
ALA A 350
SER A  56
ALA A 352
 None
 0.79A 4twdF-1as4A:
0.9
4twdG-1as4A:
0.8
4twdH-1as4A:
0.5
4twdI-1as4A:
0.0
4twdJ-1as4A:
0.4		 4twdF-1as4A:
22.22
4twdG-1as4A:
22.22
4twdH-1as4A:
22.22
4twdI-1as4A:
22.22
4twdJ-1as4A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_B_29SB601_1
(ESTROGEN RECEPTOR)		 1as4 ANTICHYMOTRYPSIN
(Homo
sapiens) 		6 / 12 THR A  59
ALA A  60
LEU A 184
LEU A 299
GLY A  79
LEU A  80
 None
 1.29A 4xi3B-1as4A:
undetectable		 4xi3B-1as4A:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_C_29SC601_1
(ESTROGEN RECEPTOR)		 1as4 ANTICHYMOTRYPSIN
(Homo
sapiens) 		6 / 12 THR A  59
ALA A  60
LEU A 184
LEU A 299
GLY A  79
LEU A  80
 None
 1.27A 4xi3C-1as4A:
undetectable		 4xi3C-1as4A:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_E_4LEE401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 1as4 ANTICHYMOTRYPSIN
(Homo
sapiens) 		4 / 7 THR A 102
LEU A 103
LEU A  99
THR B 379
 None
 0.89A 4z90A-1as4A:
1.0
4z90B-1as4A:
1.0
4z90C-1as4A:
0.9
4z90D-1as4A:
1.0
4z90E-1as4A:
0.8		 4z90A-1as4A:
22.37
4z90B-1as4A:
22.37
4z90C-1as4A:
22.37
4z90D-1as4A:
22.37
4z90E-1as4A:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEP_A_VDYA201_2
(CDL2.3B)		 1as4 ANTICHYMOTRYPSIN
(Homo
sapiens) 		5 / 9 ILE A  57
VAL A 161
LEU A 172
ILE A 169
LEU A 303
 None
 1.31A 5iepA-1as4A:
0.6		 5iepA-1as4A:
16.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5OM2_B_DXTB501_1
(ALPHA-1-ANTICHYMOTRY
PSIN)		 1as4 ANTICHYMOTRYPSIN
(Homo
sapiens) 		5 / 9 VAL A  31
LEU A 272
ASP A 277
VAL B 375
ILE B 382
 None
 0.40A 5om2A-1as4A:
50.4
5om2B-1as4A:
undetectable		 5om2A-1as4A:
98.08
5om2B-1as4A:
9.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5OM3_B_DXTB501_1
(ALPHA-1-ANTICHYMOTRY
PSIN)		 1as4 ANTICHYMOTRYPSIN
(Homo
sapiens) 		4 / 6 LEU A  37
SER A  36
PHE A  33
ASP A  32
 None
 1.09A 5om3A-1as4A:
49.8
5om3B-1as4A:
0.0		 5om3A-1as4A:
98.08
5om3B-1as4A:
9.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_B_RITB602_1
(CYTOCHROME P450 3A5)		 1as4 ANTICHYMOTRYPSIN
(Homo
sapiens) 		5 / 12 SER A  53
LEU A  55
ILE A 188
PHE A 190
ALA A 347
 None
None
None
None
ACT  B 600 (-3.6A)
 1.07A 5veuB-1as4A:
undetectable		 5veuB-1as4A:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_D_ADND502_1
(ADENOSYLHOMOCYSTEINA
SE)		 1as4 ANTICHYMOTRYPSIN
(Homo
sapiens) 		3 / 3 LEU A  80
ASN A 116
LEU A  99
 None
 0.68A 6exiD-1as4A:
undetectable		 6exiD-1as4A:
13.69