SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1at0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYR_B_RITB301_1
(HIV-1 PROTEASE)		 1at0 17-HEDGEHOG
(Drosophila
melanogaster) 		4 / 7 LEU A 323
ALA A 346
ASP A 347
VAL A 373
 None
 0.92A 4eyrA-1at0A:
0.0		 4eyrA-1at0A:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MGH_A_ACTA1320_0
(PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE)		 1at0 17-HEDGEHOG
(Drosophila
melanogaster) 		4 / 5 VAL A 382
LEU A 306
LEU A 278
ARG A 304
 None
 0.79A 4mghA-1at0A:
undetectable		 4mghA-1at0A:
7.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_B_LOCB503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 1at0 17-HEDGEHOG
(Drosophila
melanogaster) 		3 / 3 SER A 399
ALA A 397
VAL A 396
 None
 0.46A 4o2bA-1at0A:
undetectable		 4o2bA-1at0A:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_D_LOCD503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 1at0 17-HEDGEHOG
(Drosophila
melanogaster) 		3 / 3 SER A 399
ALA A 397
VAL A 396
 None
 0.52A 4o2bC-1at0A:
undetectable		 4o2bC-1at0A:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNW_A_RTZA602_1
(CYTOCHROME P450 2D6)		 1at0 17-HEDGEHOG
(Drosophila
melanogaster) 		5 / 12 PHE A 312
GLY A 276
LEU A 278
VAL A 298
THR A 386
 None
 1.20A 4wnwA-1at0A:
undetectable		 4wnwA-1at0A:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EYP_B_LOCB502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 1at0 17-HEDGEHOG
(Drosophila
melanogaster) 		3 / 3 SER A 399
ALA A 397
VAL A 396
 None
 0.57A 5eypA-1at0A:
undetectable		 5eypA-1at0A:
15.25