SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1at3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBM_B_RTLB951_2
(PROTEIN (CARTILAGE
OLIGOMERIC MATRIX
PROTEIN))		 1at3 HERPES SIMPLEX VIRUS
TYPE II PROTEASE
(Human
alphaherpesvirus
2) 		4 / 4 THR A 210
LEU A 213
VAL A  59
LEU A 151
 None
 0.91A 1fbmD-1at3A:
0.0		 1fbmD-1at3A:
11.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_4
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 1at3 HERPES SIMPLEX VIRUS
TYPE II PROTEASE
(Human
alphaherpesvirus
2) 		4 / 4 THR A 210
LEU A 213
VAL A  59
LEU A 151
 None
 0.99A 1mz9D-1at3A:
undetectable		 1mz9D-1at3A:
10.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QL8_B_BEZB143_0
(PUTATIVE REDOX
PROTEIN)		 1at3 HERPES SIMPLEX VIRUS
TYPE II PROTEASE
(Human
alphaherpesvirus
2) 		4 / 6 ARG A  64
THR A 212
ALA A 208
ARG A  62
 None
 1.23A 2ql8A-1at3A:
0.1
2ql8B-1at3A:
0.0		 2ql8A-1at3A:
20.80
2ql8B-1at3A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AX9_B_SALB1340_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 1at3 HERPES SIMPLEX VIRUS
TYPE II PROTEASE
(Human
alphaherpesvirus
2) 		4 / 8 GLU A  92
LEU A 117
THR A 166
ALA A  18
 None
 0.91A 3ax9B-1at3A:
undetectable		 3ax9B-1at3A:
10.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S54_B_017B201_1
(PROTEASE)		 1at3 HERPES SIMPLEX VIRUS
TYPE II PROTEASE
(Human
alphaherpesvirus
2) 		6 / 12 ARG A 233
LEU A 158
ASP A  34
ALA A  39
ASP A  41
VAL A  45
 None
 1.46A 3s54A-1at3A:
undetectable		 3s54A-1at3A:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ6_A_SAMA300_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 1at3 HERPES SIMPLEX VIRUS
TYPE II PROTEASE
(Human
alphaherpesvirus
2) 		4 / 4 SER A 129
ASP A  34
ASP A  31
ALA A  28
 DFP  A 300 ( 1.5A)
None
None
None
 1.36A 3uj6A-1at3A:
undetectable		 3uj6A-1at3A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 1at3 HERPES SIMPLEX VIRUS
TYPE II PROTEASE
(Human
alphaherpesvirus
2) 		5 / 12 SER A 129
VAL A 128
ILE A  57
ASN A  58
PHE A  82
 DFP  A 300 ( 1.5A)
None
None
None
None
 1.30A 4c49A-1at3A:
undetectable		 4c49A-1at3A:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_B_HCYB1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 1at3 HERPES SIMPLEX VIRUS
TYPE II PROTEASE
(Human
alphaherpesvirus
2) 		5 / 12 SER A 129
VAL A 128
ILE A  57
ASN A  58
PHE A  82
 DFP  A 300 ( 1.5A)
None
None
None
None
 1.30A 4c49B-1at3A:
0.0		 4c49B-1at3A:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLR_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1at3 HERPES SIMPLEX VIRUS
TYPE II PROTEASE
(Human
alphaherpesvirus
2) 		3 / 3 LEU A  55
PRO A  56
ARG A 157
 None
None
DFP  A 300 ( 3.9A)
 0.57A 4klrB-1at3A:
undetectable		 4klrB-1at3A:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M48_A_21BA704_1
(TRANSPORTER)		 1at3 HERPES SIMPLEX VIRUS
TYPE II PROTEASE
(Human
alphaherpesvirus
2) 		4 / 8 ASP A 169
VAL A  83
SER A 167
ALA A  72
 None
 0.86A 4m48A-1at3A:
0.0		 4m48A-1at3A:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE5_A_OBNA1104_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 1at3 HERPES SIMPLEX VIRUS
TYPE II PROTEASE
(Human
alphaherpesvirus
2) 		4 / 6 ILE A 121
VAL A  94
THR A 212
ARG A 226
 None
 1.17A 4xe5A-1at3A:
undetectable		 4xe5A-1at3A:
14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BYK_A_OAQA302_0
(SULFOTRANSFERASE)		 1at3 HERPES SIMPLEX VIRUS
TYPE II PROTEASE
(Human
alphaherpesvirus
2) 		5 / 12 PRO A  51
LEU A  55
VAL A  74
VAL A  73
LEU A 168
 None
 1.15A 5bykA-1at3A:
0.0		 5bykA-1at3A:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_A_BZMA301_0
(ISATIN HYDROLASE A)		 1at3 HERPES SIMPLEX VIRUS
TYPE II PROTEASE
(Human
alphaherpesvirus
2) 		5 / 12 ILE A  57
LEU A 151
VAL A  70
GLY A  84
TYR A 164
 None
 1.06A 5nnaA-1at3A:
undetectable		 5nnaA-1at3A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_B_BZMB301_0
(ISATIN HYDROLASE A)		 1at3 HERPES SIMPLEX VIRUS
TYPE II PROTEASE
(Human
alphaherpesvirus
2) 		5 / 12 ILE A  57
LEU A 151
VAL A  70
GLY A  84
TYR A 164
 None
 0.95A 5nnaB-1at3A:
undetectable		 5nnaB-1at3A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_C_BZMC301_0
(ISATIN HYDROLASE A)		 1at3 HERPES SIMPLEX VIRUS
TYPE II PROTEASE
(Human
alphaherpesvirus
2) 		5 / 12 ILE A  57
LEU A 151
VAL A  70
GLY A  84
TYR A 164
 None
 0.91A 5nnaC-1at3A:
undetectable		 5nnaC-1at3A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_D_BZMD301_0
(ISATIN HYDROLASE A)		 1at3 HERPES SIMPLEX VIRUS
TYPE II PROTEASE
(Human
alphaherpesvirus
2) 		5 / 12 ILE A  57
LEU A 151
VAL A  70
GLY A  84
TYR A 164
 None
 1.07A 5nnaD-1at3A:
undetectable		 5nnaD-1at3A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_A_RITA602_1
(CYTOCHROME P450 3A5)		 1at3 HERPES SIMPLEX VIRUS
TYPE II PROTEASE
(Human
alphaherpesvirus
2) 		5 / 12 ARG A 156
SER A 127
ILE A 161
ALA A 237
GLY A  33
 None
 1.14A 5veuA-1at3A:
0.0		 5veuA-1at3A:
18.72