SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ati'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK7_B_ADNB1246_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 1ati GLYCYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		4 / 8 ARG A 431
GLY A  35
VAL A  39
GLU A  40
 None
 0.71A 1pk7B-1atiA:
undetectable		 1pk7B-1atiA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9Q_A_CHDA459_0
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 1ati GLYCYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		4 / 6 LEU A 390
VAL A 389
ILE A 388
TYR A 296
 None
 1.03A 1s9qA-1atiA:
0.1		 1s9qA-1atiA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WG8_A_SAMA3142_0
(PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 1ati GLYCYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		5 / 12 GLY A 363
GLY A 367
GLN A 214
SER A 361
ARG A 260
 None
 1.11A 1wg8A-1atiA:
undetectable		 1wg8A-1atiA:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BJF_A_DXCA330_0
(CHOLOYLGLYCINE
HYDROLASE)		 1ati GLYCYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		5 / 12 ARG A 260
PHE A 230
ALA A 362
ILE A 229
LEU A  45
 None
 1.12A 2bjfA-1atiA:
0.0		 2bjfA-1atiA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		 1ati GLYCYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		4 / 7 LEU A  45
LEU A 396
GLU A 259
ARG A  52
 None
 0.92A 2jn3A-1atiA:
0.0		 2jn3A-1atiA:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLC_A_CHDA332_0
(CHOLOYLGLYCINE
HYDROLASE)		 1ati GLYCYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		5 / 12 ARG A 260
PHE A 230
ALA A 362
ILE A 229
LEU A  45
 None
 1.09A 2rlcA-1atiA:
0.0		 2rlcA-1atiA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XDC_D_DVAD8_0
(GRAMICIDIN A)		 1ati GLYCYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		3 / 3 TRP A 252
VAL A 357
TRP A 256
 None
 1.22A 2xdcC-1atiA:
undetectable
2xdcD-1atiA:
undetectable		 2xdcC-1atiA:
5.80
2xdcD-1atiA:
5.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XDC_F_DVAF8_0
(GRAMICIDIN A)		 1ati GLYCYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		3 / 3 TRP A 252
VAL A 357
TRP A 256
 None
 1.26A 2xdcE-1atiA:
undetectable
2xdcF-1atiA:
undetectable		 2xdcE-1atiA:
5.80
2xdcF-1atiA:
5.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y5M_F_DVAF8_0
(VAL-GRAMICIDIN A)		 1ati GLYCYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		3 / 3 TRP A 252
VAL A 357
TRP A 256
 None
 1.20A 2y5mE-1atiA:
undetectable
2y5mF-1atiA:
undetectable		 2y5mE-1atiA:
5.80
2y5mF-1atiA:
5.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6N_D_DVAD8_0
(VAL-GRAMICIDIN A)		 1ati GLYCYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		3 / 3 TRP A 252
VAL A 357
TRP A 256
 None
 1.22A 2y6nC-1atiA:
undetectable
2y6nD-1atiA:
undetectable		 2y6nC-1atiA:
5.80
2y6nD-1atiA:
5.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6N_F_DVAF8_0
(VAL-GRAMICIDIN A)		 1ati GLYCYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		3 / 3 TRP A 252
VAL A 357
TRP A 256
 None
 1.23A 2y6nE-1atiA:
undetectable
2y6nF-1atiA:
undetectable		 2y6nE-1atiA:
5.80
2y6nF-1atiA:
5.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ZT7_A_GLYA1300_0
(GLYCYL-TRNA
SYNTHETASE)		 1ati GLYCYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		5 / 7 GLU A 188
GLU A 239
ARG A 311
GLU A 359
SER A 361
 None
 0.65A 2zt7A-1atiA:
33.2		 2zt7A-1atiA:
30.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AI8_A_HNQA255_1
(CATHEPSIN B)		 1ati GLYCYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		4 / 7 GLN A 191
GLY A 192
HIS A  79
HIS A 319
 None
 1.20A 3ai8A-1atiA:
undetectable		 3ai8A-1atiA:
19.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KR3_A_GLYA701_0
(GLYCINE--TRNA LIGASE)		 1ati GLYCYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		4 / 6 ARG A 220
GLU A 239
ARG A 311
SER A 361
 None
 1.03A 4kr3A-1atiA:
35.3		 4kr3A-1atiA:
32.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KR3_A_GLYA701_0
(GLYCINE--TRNA LIGASE)		 1ati GLYCYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		5 / 6 GLU A 188
GLU A 239
ARG A 311
GLU A 359
SER A 361
 None
 0.82A 4kr3A-1atiA:
35.3		 4kr3A-1atiA:
32.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_A_HFGA803_0
(PROLINE--TRNA LIGASE)		 1ati GLYCYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		5 / 12 LEU A  74
PRO A 187
ARG A 220
SER A 361
GLY A 363
 None
 1.29A 4q15A-1atiA:
26.3		 4q15A-1atiA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_B_HFGB803_0
(PROLINE--TRNA LIGASE)		 1ati GLYCYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		5 / 12 LEU A  74
PRO A 187
ARG A 220
SER A 361
GLY A 363
 None
 1.32A 4q15B-1atiA:
26.5		 4q15B-1atiA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YDQ_A_HFGA802_0
(PROLINE--TRNA LIGASE)		 1ati GLYCYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		5 / 12 LEU A  74
PRO A 187
ARG A 220
SER A 361
GLY A 363
 None
 1.27A 4ydqA-1atiA:
25.4		 4ydqA-1atiA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F9Z_A_HFGA702_0
(AMINOACYL-TRNA
SYNTHETASE)		 1ati GLYCYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		5 / 12 LEU A  74
PRO A 187
ARG A 220
SER A 361
GLY A 363
 None
 1.31A 5f9zA-1atiA:
25.1		 5f9zA-1atiA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F9Z_B_HFGB703_0
(AMINOACYL-TRNA
SYNTHETASE)		 1ati GLYCYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		5 / 12 LEU A  74
PRO A 187
ARG A 220
SER A 361
GLY A 363
 None
 1.37A 5f9zB-1atiA:
25.2		 5f9zB-1atiA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC4_A_RBFA201_2
(RIBOFLAVIN
TRANSPORTER RIBU)		 1ati GLYCYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		3 / 3 LYS A  13
LEU A   5
ILE A 229
 None
 0.79A 5kc4A-1atiA:
0.0		 5kc4A-1atiA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_B_SAMB303_0
(METHYLTRANSFERASE)		 1ati GLYCYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		5 / 12 LEU A  11
ALA A  10
VAL A   9
ALA A 373
TYR A 296
 None
 0.99A 5n5dB-1atiA:
undetectable		 5n5dB-1atiA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_A_SAMA501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 1ati GLYCYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		5 / 11 LEU A 392
PRO A 398
GLU A 449
LEU A 371
ALA A 375
 None
 1.12A 5o96A-1atiA:
2.8
5o96B-1atiA:
undetectable		 5o96A-1atiA:
19.56
5o96B-1atiA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AZ3_1_PAR11802_1
(RRNA ALPHA
RIBOSOMAL PROTEIN
UL4
RIBOSOMAL PROTEIN
UL15
RIBOSOMAL PROTEIN
EL15)		 1ati GLYCYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		3 / 3 ARG A 446
LYS A 408
ARG A  15
 None
 1.06A 6az3C-1atiA:
0.0
6az3L-1atiA:
0.0
6az3M-1atiA:
0.0		 6az3C-1atiA:
10.64
6az3L-1atiA:
7.72
6az3M-1atiA:
10.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BNI_A_ADNA602_1
(LYSINE--TRNA LIGASE)		 1ati GLYCYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		5 / 10 ARG A 220
GLU A 304
GLY A 363
ARG A 366
ILE A 229
 None
 0.92A 6bniA-1atiA:
14.4		 6bniA-1atiA:
10.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BNI_A_ADNA602_1
(LYSINE--TRNA LIGASE)		 1ati GLYCYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		5 / 10 ARG A 220
PHE A 235
GLY A 363
ARG A 366
ILE A 229
 None
 0.94A 6bniA-1atiA:
14.4		 6bniA-1atiA:
10.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BNI_B_ADNB602_1
(LYSINE--TRNA LIGASE)		 1ati GLYCYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		5 / 10 ARG A 220
GLU A 304
GLY A 363
ARG A 366
ILE A 229
 None
 0.84A 6bniB-1atiA:
14.4		 6bniB-1atiA:
10.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BNI_B_ADNB602_1
(LYSINE--TRNA LIGASE)		 1ati GLYCYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		5 / 10 ARG A 220
PHE A 235
GLY A 363
ARG A 366
ILE A 229
 None
 0.90A 6bniB-1atiA:
14.4		 6bniB-1atiA:
10.04