SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1att'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TLS_A_C2FA266_0
(THYMIDYLATE SYNTHASE)		 1att ANTITHROMBIN III
(Bos
taurus) 		5 / 12 ILE A 391
LEU A 171
GLY A  94
VAL A 356
ALA A 357
 None
 1.05A 1tlsA-1attA:
0.0		 1tlsA-1attA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TLS_B_C2FB266_0
(THYMIDYLATE SYNTHASE)		 1att ANTITHROMBIN III
(Bos
taurus) 		5 / 12 ILE A 391
LEU A 171
GLY A  94
VAL A 356
ALA A 357
 None
 1.10A 1tlsB-1attA:
0.0		 1tlsB-1attA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TSN_A_C2FA266_0
(THYMIDYLATE SYNTHASE)		 1att ANTITHROMBIN III
(Bos
taurus) 		5 / 12 ILE A 391
LEU A 171
GLY A  94
VAL A 356
ALA A 357
 None
 1.13A 1tsnA-1attA:
0.0		 1tsnA-1attA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		 1att ANTITHROMBIN III
(Bos
taurus) 		3 / 3 LEU A 336
LEU A  79
PHE A 107
 None
 0.55A 2pgrA-1attA:
undetectable		 2pgrA-1attA:
24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYM_A_1UNA1001_3
(PROTEASE RETROPEPSIN)		 1att ANTITHROMBIN III
(Bos
taurus) 		3 / 3 ASP A 201
ASN A 188
THR A 219
 None
 0.68A 2pymB-1attA:
0.0		 2pymB-1attA:
12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q63_A_1UNA1001_4
(PROTEASE RETROPEPSIN)		 1att ANTITHROMBIN III
(Bos
taurus) 		3 / 3 ASP A 201
ASN A 188
THR A 219
 None
 0.74A 2q63B-1attA:
0.0		 2q63B-1attA:
12.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_A_KLNA1501_1
(CYTOCHROME P450 3A4)		 1att ANTITHROMBIN III
(Bos
taurus) 		5 / 10 SER A  83
ILE A 220
LEU A 273
THR A 281
GLY A 425
 None
 1.33A 2v0mA-1attA:
0.0		 2v0mA-1attA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1359_1
(PROSTAGLANDIN
REDUCTASE 2)		 1att ANTITHROMBIN III
(Bos
taurus) 		4 / 6 THR A 420
GLU A 415
PHE A 222
ILE A 220
 None
 1.22A 2w98B-1attA:
undetectable		 2w98B-1attA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X91_A_LPRA1615_2
(ANGIOTENSIN
CONVERTING ENZYME)		 1att ANTITHROMBIN III
(Bos
taurus) 		3 / 3 SER A 390
THR A  91
PHE A  59
 None
 0.77A 2x91A-1attA:
0.0		 2x91A-1attA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCR_A_CHDA424_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1att ANTITHROMBIN III
(Bos
taurus) 		4 / 8 LEU A 103
PRO A  20
GLY A 354
PRO A 353
 None
 1.07A 3hcrA-1attA:
undetectable		 3hcrA-1attA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS6_B_EPAB1_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1att ANTITHROMBIN III
(Bos
taurus) 		4 / 7 PHE A 122
VAL A  49
LEU A  52
SER A  53
 None
 0.88A 3hs6B-1attA:
0.0		 3hs6B-1attA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_B_TFPB201_1
(PROTEIN S100-A4)		 1att ANTITHROMBIN III
(Bos
taurus) 		4 / 8 ILE A 389
PHE A 124
PHE A 107
PHE A 109
 None
 1.04A 3ko0B-1attA:
0.3
3ko0J-1attA:
0.3		 3ko0B-1attA:
11.81
3ko0J-1attA:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_B_TFPB201_1
(PROTEIN S100-A4)		 1att ANTITHROMBIN III
(Bos
taurus) 		4 / 8 ILE A 421
PHE A 107
PHE A 109
PHE A 124
 None
 1.03A 3ko0B-1attA:
0.3
3ko0J-1attA:
0.3		 3ko0B-1attA:
11.81
3ko0J-1attA:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_D_TFPD201_1
(PROTEIN S100-A4)		 1att ANTITHROMBIN III
(Bos
taurus) 		4 / 8 GLY A 340
PHE A 124
PHE A 107
PHE A 109
 None
 1.04A 3ko0D-1attA:
0.4
3ko0E-1attA:
0.3		 3ko0D-1attA:
11.81
3ko0E-1attA:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_J_TFPJ201_1
(PROTEIN S100-A4)		 1att ANTITHROMBIN III
(Bos
taurus) 		4 / 8 PHE A 107
PHE A 109
GLY A 340
PHE A 124
 None
 1.04A 3ko0B-1attA:
0.3
3ko0J-1attA:
0.3		 3ko0B-1attA:
11.81
3ko0J-1attA:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_K_TFPK201_1
(PROTEIN S100-A4)		 1att ANTITHROMBIN III
(Bos
taurus) 		4 / 8 ILE A 389
PHE A 124
PHE A 107
PHE A 109
 None
 1.04A 3ko0K-1attA:
0.3
3ko0S-1attA:
0.3		 3ko0K-1attA:
11.81
3ko0S-1attA:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_L_TFPL201_1
(PROTEIN S100-A4)		 1att ANTITHROMBIN III
(Bos
taurus) 		4 / 7 GLY A 340
PHE A 124
PHE A 107
PHE A 109
 None
 1.15A 3ko0L-1attA:
0.4
3ko0N-1attA:
0.3		 3ko0L-1attA:
11.81
3ko0N-1attA:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_S_TFPS201_1
(PROTEIN S100-A4)		 1att ANTITHROMBIN III
(Bos
taurus) 		4 / 7 PHE A 107
PHE A 109
GLY A 340
PHE A 124
 None
 1.08A 3ko0K-1attA:
0.3
3ko0S-1attA:
0.3		 3ko0K-1attA:
11.81
3ko0S-1attA:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_T_TFPT201_1
(PROTEIN S100-A4)		 1att ANTITHROMBIN III
(Bos
taurus) 		4 / 7 PHE A 107
PHE A 109
GLY A 340
PHE A 124
 None
 1.10A 3ko0R-1attA:
0.3
3ko0T-1attA:
0.3		 3ko0R-1attA:
11.81
3ko0T-1attA:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3003_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 1att ANTITHROMBIN III
(Bos
taurus) 		4 / 6 ILE A 413
VAL A 411
LEU A 284
LEU A 273
 None
 0.78A 3kp6A-1attA:
0.0
3kp6B-1attA:
0.0		 3kp6A-1attA:
16.08
3kp6B-1attA:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDT_A_VORA506_1
(CHOLESTEROL
24-HYDROXYLASE)		 1att ANTITHROMBIN III
(Bos
taurus) 		5 / 9 LEU A 214
VAL A 365
ALA A 368
THR A 387
ALA A  87
 None
 1.24A 3mdtA-1attA:
0.3		 3mdtA-1attA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDT_A_VORA506_1
(CHOLESTEROL
24-HYDROXYLASE)		 1att ANTITHROMBIN III
(Bos
taurus) 		5 / 9 LEU A 341
PHE A 345
VAL A 332
ALA A  87
THR A  91
 None
 1.21A 3mdtA-1attA:
0.3		 3mdtA-1attA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFT_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1att ANTITHROMBIN III
(Bos
taurus) 		4 / 7 VAL A 376
TRP A 226
PHE A 275
GLU A 379
 None
 1.50A 3uftA-1attA:
0.0
3uftB-1attA:
0.0		 3uftA-1attA:
21.06
3uftB-1attA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UM5_A_CP6A609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1att ANTITHROMBIN III
(Bos
taurus) 		5 / 10 ILE A 391
THR A 387
SER A 386
ILE A 389
THR A 212
 None
 1.39A 3um5A-1attA:
undetectable		 3um5A-1attA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UM5_B_CP6B709_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1att ANTITHROMBIN III
(Bos
taurus) 		5 / 10 ILE A 391
THR A 387
SER A 386
ILE A 389
THR A 212
 None
 1.34A 3um5B-1attA:
undetectable		 3um5B-1attA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IK7_A_IMNA201_1
(TRANSTHYRETIN)		 1att ANTITHROMBIN III
(Bos
taurus) 		4 / 7 MET A 104
LEU A  93
ALA A  89
THR A  86
 None
 0.84A 4ik7A-1attA:
0.0		 4ik7A-1attA:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IMW_A_H4BA805_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1att ANTITHROMBIN III
(Bos
taurus) 		4 / 7 TRP A 226
PHE A 275
GLU A 379
VAL A 376
 None
 1.47A 4imwA-1attA:
0.0
4imwB-1attA:
0.0		 4imwA-1attA:
21.06
4imwB-1attA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V1F_A_BQ1A1087_0
(F0F1 ATP SYNTHASE
SUBUNIT C)		 1att ANTITHROMBIN III
(Bos
taurus) 		3 / 3 GLU A 382
ALA A 383
PHE A 373
 None
 0.63A 4v1fA-1attA:
undetectable		 4v1fA-1attA:
11.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V1F_C_BQ1C1087_0
(F0F1 ATP SYNTHASE
SUBUNIT C)		 1att ANTITHROMBIN III
(Bos
taurus) 		3 / 3 GLU A 382
ALA A 383
PHE A 373
 None
 0.67A 4v1fC-1attA:
undetectable		 4v1fC-1attA:
11.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_W_BEZW801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 1att ANTITHROMBIN III
(Bos
taurus) 		4 / 5 PHE A 176
GLY A 149
ILE A 208
LEU A 214
 None
 0.84A 5dzkB-1attA:
undetectable
5dzkI-1attA:
0.0
5dzkW-1attA:
undetectable		 5dzkB-1attA:
17.51
5dzkI-1attA:
19.91
5dzkW-1attA:
0.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_Y_BEZY801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 1att ANTITHROMBIN III
(Bos
taurus) 		4 / 5 PHE A 176
GLY A 149
ILE A 208
LEU A 214
 None
 0.85A 5dzkd-1attA:
undetectable
5dzkk-1attA:
undetectable
5dzky-1attA:
undetectable		 5dzkd-1attA:
17.51
5dzkk-1attA:
19.91
5dzky-1attA:
0.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JH7_B_6K9B503_0
(TUBULIN BETA-2B
CHAIN)		 1att ANTITHROMBIN III
(Bos
taurus) 		5 / 11 ASN A 209
VAL A 365
SER A 366
ASP A 367
LEU A 352
 None
 1.43A 5jh7B-1attA:
undetectable		 5jh7B-1attA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JH7_D_6K9D502_0
(TUBULIN BETA-2B
CHAIN)		 1att ANTITHROMBIN III
(Bos
taurus) 		5 / 11 ASN A 209
VAL A 365
SER A 366
ASP A 367
LEU A 352
 None
 1.39A 5jh7D-1attA:
undetectable		 5jh7D-1attA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVS_A_ADNA401_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 1att ANTITHROMBIN III
(Bos
taurus) 		4 / 7 GLU A 297
ALA A 294
ASP A  69
ASN A  76
 None
 0.98A 5mvsA-1attA:
undetectable		 5mvsA-1attA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVS_B_ADNB401_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 1att ANTITHROMBIN III
(Bos
taurus) 		4 / 8 GLU A 297
ALA A 294
ASP A  69
ASN A  76
 None
 0.96A 5mvsB-1attA:
undetectable		 5mvsB-1attA:
21.03