SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1au1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		 1au1 INTERFERON-BETA
(Homo
sapiens) 		4 / 6 LEU A  87
ASN A 158
ILE A  66
PHE A  70
 None
 1.16A 2jn3A-1au1A:
0.0		 2jn3A-1au1A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_C_CHDC102_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 1au1 INTERFERON-BETA
(Homo
sapiens) 		4 / 7 GLU A  61
LEU A  57
LEU A 102
LEU A 106
 None
 0.73A 4wg0B-1au1A:
undetectable
4wg0C-1au1A:
undetectable		 4wg0B-1au1A:
5.07
4wg0C-1au1A:
5.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_L_CHDL103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 1au1 INTERFERON-BETA
(Homo
sapiens) 		4 / 7 LEU A 102
LEU A 106
GLU A  61
LEU A  57
 None
 0.82A 4wg0L-1au1A:
undetectable
4wg0M-1au1A:
undetectable		 4wg0L-1au1A:
5.07
4wg0M-1au1A:
5.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_D_ERMD1201_2
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 1au1 INTERFERON-BETA
(Homo
sapiens) 		4 / 6 LEU A 106
VAL A 101
LEU A 160
GLU A  61
 None
 0.92A 5tudD-1au1A:
2.7		 5tudD-1au1A:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_B_ACRB602_2
(-)		 1au1 INTERFERON-BETA
(Homo
sapiens) 		4 / 8 VAL A 146
TYR A 132
TYR A 138
GLU A  81
 None
 1.24A 6gneB-1au1A:
undetectable		 6gneB-1au1A:
14.26