SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1au8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1AQ7_B_AG2B4_1
(TRYPSIN
AERUGINOSIN 98-B)		 1au8 CATHEPSIN G
(Homo
sapiens) 		4 / 8 HIS A  57
SER A 195
VAL A 213
GLY A 216
 0H8  A   1 (-3.3A)
0H8  A   1 (-1.5A)
None
0H8  A   1 (-4.2A)
 0.60A 1aq7A-1au8A:
35.3		 1aq7A-1au8A:
35.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CQE_A_FLPA1650_1
(PROTEIN
(PROSTAGLANDIN H2
SYNTHASE-1))		 1au8 CATHEPSIN G
(Homo
sapiens) 		5 / 12 LEU A  68
ILE A  64
ALA A  85
SER A 109
LEU A 108
 None
 0.96A 1cqeA-1au8A:
0.0		 1cqeA-1au8A:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CQE_B_FLPB2650_1
(PROTEIN
(PROSTAGLANDIN H2
SYNTHASE-1))		 1au8 CATHEPSIN G
(Homo
sapiens) 		5 / 12 LEU A  68
ILE A  64
ALA A  85
SER A 109
LEU A 108
 None
 0.96A 1cqeB-1au8A:
undetectable		 1cqeB-1au8A:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_C_PPFC413_1
(PHOSPHONOACETATE
HYDROLASE)		 1au8 CATHEPSIN G
(Homo
sapiens) 		4 / 8 PHE A 228
THR A 229
ASP A 102
HIS A  57
 None
None
None
0H8  A   1 (-3.3A)
 0.88A 1ei6C-1au8A:
undetectable		 1ei6C-1au8A:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQG_A_IBPA701_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 1au8 CATHEPSIN G
(Homo
sapiens) 		6 / 9 VAL A  52
LEU A  68
ILE A  64
ALA A  85
SER A 109
LEU A 108
 None
 1.02A 1eqgA-1au8A:
0.0		 1eqgA-1au8A:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQG_B_IBPB1701_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 1au8 CATHEPSIN G
(Homo
sapiens) 		6 / 11 VAL A  52
LEU A  68
ILE A  64
ALA A  85
SER A 109
LEU A 108
 None
 1.02A 1eqgB-1au8A:
0.0		 1eqgB-1au8A:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQH_A_FLPA701_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 1au8 CATHEPSIN G
(Homo
sapiens) 		6 / 12 VAL A  52
LEU A  68
ILE A  64
ALA A  85
SER A 109
LEU A 108
 None
 1.04A 1eqhA-1au8A:
0.0		 1eqhA-1au8A:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQH_B_FLPB1701_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 1au8 CATHEPSIN G
(Homo
sapiens) 		6 / 12 VAL A  52
LEU A  68
ILE A  64
ALA A  85
SER A 109
LEU A 108
 None
 1.04A 1eqhB-1au8A:
0.0		 1eqhB-1au8A:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JTV_A_TESA500_1
(17
BETA-HYDROXYSTEROID
DEHYDROGENASE TYPE 1)		 1au8 CATHEPSIN G
(Homo
sapiens) 		4 / 8 LEU A 235
HIS A 210
VAL A 204
GLU A 128
 None
 0.75A 1jtvA-1au8A:
undetectable		 1jtvA-1au8A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AYL_B_FLPB2701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1au8 CATHEPSIN G
(Homo
sapiens) 		5 / 12 LEU A  68
ILE A  64
ALA A  85
SER A 109
LEU A 108
 None
 1.01A 2aylB-1au8A:
0.0		 2aylB-1au8A:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KCE_A_D16A566_1
(THYMIDYLATE SYNTHASE)		 1au8 CATHEPSIN G
(Homo
sapiens) 		5 / 12 SER A  26
LEU A 199
ASP A 194
GLY A 140
ALA A 189
 None
None
None
None
0H8  A   1 ( 4.6A)
 1.18A 2kceA-1au8A:
0.0		 2kceA-1au8A:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DVAC59_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 1au8 CATHEPSIN G
(Homo
sapiens) 		3 / 3 GLY A 197
GLY A 193
GLY A  43
 None
0H8  A   1 (-3.4A)
None
 0.41A 3bogC-1au8A:
0.0		 3bogC-1au8A:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_B_TFPB201_1
(PROTEIN S100-A4)		 1au8 CATHEPSIN G
(Homo
sapiens) 		4 / 8 GLY A 184
ILE A  16
PHE A  45
PHE A 228
 None
 1.05A 3ko0B-1au8A:
undetectable
3ko0J-1au8A:
undetectable		 3ko0B-1au8A:
15.31
3ko0J-1au8A:
15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8W_A_FLPA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1au8 CATHEPSIN G
(Homo
sapiens) 		5 / 12 VAL A  52
LEU A  68
ALA A  85
SER A 109
LEU A 108
 None
 0.76A 3n8wA-1au8A:
undetectable		 3n8wA-1au8A:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Z_A_FLPA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1au8 CATHEPSIN G
(Homo
sapiens) 		5 / 12 VAL A  52
LEU A  68
ALA A  85
SER A 109
LEU A 108
 None
 0.77A 3n8zA-1au8A:
0.0		 3n8zA-1au8A:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NK2_X_LDPX433_1
(6-HYDROXY-L-NICOTINE
OXIDASE)		 1au8 CATHEPSIN G
(Homo
sapiens) 		4 / 7 MET A  30
LEU A 155
LEU A 200
PHE A  45
 None
 1.21A 3nk2X-1au8A:
undetectable		 3nk2X-1au8A:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_A_FLPA701_1
(CYCLOOXYGENASE-2)		 1au8 CATHEPSIN G
(Homo
sapiens) 		5 / 12 VAL A  52
LEU A  68
ALA A  85
SER A 109
LEU A 108
 None
 0.84A 3pghA-1au8A:
0.0		 3pghA-1au8A:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_C_FLPC701_1
(CYCLOOXYGENASE-2)		 1au8 CATHEPSIN G
(Homo
sapiens) 		5 / 12 VAL A  52
LEU A  68
ALA A  85
SER A 109
LEU A 108
 None
 0.83A 3pghC-1au8A:
0.0		 3pghC-1au8A:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_A_FLRA700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1au8 CATHEPSIN G
(Homo
sapiens) 		5 / 12 VAL A  52
LEU A  68
ALA A  85
SER A 109
LEU A 108
 None
 0.92A 3rr3A-1au8A:
0.0		 3rr3A-1au8A:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_B_FLRB700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1au8 CATHEPSIN G
(Homo
sapiens) 		5 / 12 VAL A  52
LEU A  68
ALA A  85
SER A 109
LEU A 108
 None
 0.92A 3rr3B-1au8A:
undetectable		 3rr3B-1au8A:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PH9_A_IBPA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1au8 CATHEPSIN G
(Homo
sapiens) 		5 / 10 VAL A  52
LEU A  68
ALA A  85
SER A 109
LEU A 108
 None
 0.81A 4ph9A-1au8A:
0.0		 4ph9A-1au8A:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PH9_B_IBPB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1au8 CATHEPSIN G
(Homo
sapiens) 		5 / 10 VAL A  52
LEU A  68
ALA A  85
SER A 109
LEU A 108
 None
 0.80A 4ph9B-1au8A:
undetectable		 4ph9B-1au8A:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QDJ_A_SAMA301_0
(MAGNESIUM-PROTOPORPH
YRIN
O-METHYLTRANSFERASE)		 1au8 CATHEPSIN G
(Homo
sapiens) 		5 / 12 VAL A 231
GLY A  44
ILE A 103
LEU A 105
LEU A  46
 None
 1.02A 4qdjA-1au8A:
undetectable		 4qdjA-1au8A:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UW0_A_SAMA1506_0
(WBDD)		 1au8 CATHEPSIN G
(Homo
sapiens) 		5 / 12 ALA A  88
PHE A  51
GLN A 107
ARG A  48
ILE A 238
 None
 1.05A 4uw0A-1au8A:
undetectable		 4uw0A-1au8A:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JM4_A_BEZA301_0
(14-3-3 PROTEIN
ZETA/DELTA)		 1au8 CATHEPSIN G
(Homo
sapiens) 		4 / 5 PHE A 234
ILE A 103
GLN A  93
ARG A 179
 None
 1.11A 5jm4A-1au8A:
undetectable		 5jm4A-1au8A:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JM4_B_BEZB301_0
(14-3-3 PROTEIN
ZETA/DELTA)		 1au8 CATHEPSIN G
(Homo
sapiens) 		4 / 4 PHE A 234
ILE A 103
GLN A  93
ARG A 179
 None
 0.97A 5jm4B-1au8A:
undetectable		 5jm4B-1au8A:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JO9_A_SORA302_0
(RIBITOL
2-DEHYDROGENASE)		 1au8 CATHEPSIN G
(Homo
sapiens) 		5 / 12 GLY A 197
PRO A 198
VAL A 138
PHE A  45
LEU A  53
 None
 1.19A 5jo9A-1au8A:
undetectable		 5jo9A-1au8A:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JQB_B_IBPB706_1
(ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN 1
ENVELOPE
GLYCOPROTEIN 2)		 1au8 CATHEPSIN G
(Homo
sapiens) 		5 / 8 ARG A 239
LEU A 123
LEU A 235
LEU A 105
LEU A  53
 None
 1.47A 5jqbA-1au8A:
0.0
5jqbB-1au8A:
0.0		 5jqbA-1au8A:
19.51
5jqbB-1au8A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRF_D_EVPD101_1
()		 1au8 CATHEPSIN G
(Homo
sapiens) 		4 / 5 GLY A 140
ASP A 194
ARG A 156
GLN A  74
 None
 1.36A 5zrfB-1au8A:
undetectable		 5zrfB-1au8A:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_H_PCFH604_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 8
CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL)		 1au8 CATHEPSIN G
(Homo
sapiens) 		5 / 8 GLY A 216
VAL A 183
GLY A 193
SER A 195
ALA A  55
 0H8  A   1 (-4.2A)
None
0H8  A   1 (-3.4A)
0H8  A   1 (-1.5A)
None
 1.33A 6hu9H-1au8A:
0.0
6hu9e-1au8A:
undetectable		 6hu9H-1au8A:
16.59
6hu9e-1au8A:
18.84