SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1aug'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B25_A_SAMA601_0
(HYPOTHETICAL PROTEIN)		 1aug PYROGLUTAMYL
PEPTIDASE-1
(Bacillus
amyloliquefacien
s) 		5 / 12 THR A  45
GLY A  70
ARG A  75
HIS A 168
ILE A 172
 None
 0.91A 2b25A-1augA:
undetectable		 2b25A-1augA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DM6_A_IMNA1401_1
(NADP-DEPENDENT
LEUKOTRIENE B4
12-HYDROXYDEHYDROGEN
ASE)		 1aug PYROGLUTAMYL
PEPTIDASE-1
(Bacillus
amyloliquefacien
s) 		5 / 10 ILE A 189
ALA A  24
ILE A 195
PRO A 132
ILE A 126
 None
 1.31A 2dm6A-1augA:
undetectable
2dm6B-1augA:
undetectable		 2dm6A-1augA:
22.09
2dm6B-1augA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRL_A_DXTA1211_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 1aug PYROGLUTAMYL
PEPTIDASE-1
(Bacillus
amyloliquefacien
s) 		5 / 12 ASN A  19
PHE A  10
VAL A  25
LEU A 193
ILE A 169
 None
 1.50A 2xrlA-1augA:
undetectable		 2xrlA-1augA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW2_A_017A401_2
(GAG-POL POLYPROTEIN)		 1aug PYROGLUTAMYL
PEPTIDASE-1
(Bacillus
amyloliquefacien
s) 		6 / 12 LEU A   7
ALA A 200
ILE A 119
ILE A 195
VAL A  69
ILE A  67
 None
 1.38A 3jw2B-1augA:
0.0		 3jw2B-1augA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_B_0LIB1000_2
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 1aug PYROGLUTAMYL
PEPTIDASE-1
(Bacillus
amyloliquefacien
s) 		3 / 3 TYR A 113
MET A 152
ILE A  65
 None
 0.86A 4c8bB-1augA:
undetectable		 4c8bB-1augA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I41_A_MIXA501_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 1aug PYROGLUTAMYL
PEPTIDASE-1
(Bacillus
amyloliquefacien
s) 		5 / 12 ILE A 207
THR A 209
ASP A 206
THR A 115
ILE A 122
 None
 1.35A 4i41A-1augA:
undetectable		 4i41A-1augA:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_A_AERA601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 1aug PYROGLUTAMYL
PEPTIDASE-1
(Bacillus
amyloliquefacien
s) 		5 / 12 LEU A 151
ALA A  84
ILE A  66
ILE A  67
GLY A 116
 None
 0.87A 4nkvA-1augA:
0.0		 4nkvA-1augA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_B_AERB601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 1aug PYROGLUTAMYL
PEPTIDASE-1
(Bacillus
amyloliquefacien
s) 		5 / 12 LEU A 151
ALA A  84
ILE A  66
ILE A  67
GLY A 116
 None
 0.88A 4nkvB-1augA:
undetectable		 4nkvB-1augA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_C_AERC601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 1aug PYROGLUTAMYL
PEPTIDASE-1
(Bacillus
amyloliquefacien
s) 		5 / 12 LEU A 151
ALA A  84
ILE A  66
ILE A  67
GLY A 116
 None
 0.89A 4nkvC-1augA:
0.0		 4nkvC-1augA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_D_AERD601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 1aug PYROGLUTAMYL
PEPTIDASE-1
(Bacillus
amyloliquefacien
s) 		5 / 12 LEU A 151
ALA A  84
ILE A  66
ILE A  67
GLY A 116
 None
 0.90A 4nkvD-1augA:
0.0		 4nkvD-1augA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_A_STRA601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 1aug PYROGLUTAMYL
PEPTIDASE-1
(Bacillus
amyloliquefacien
s) 		5 / 12 LEU A 151
ALA A  84
ILE A  66
ILE A  67
GLY A 116
 None
 0.91A 4nkxA-1augA:
undetectable		 4nkxA-1augA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_G_FK5G201_1
(FK506-BINDING
PROTEIN 1)		 1aug PYROGLUTAMYL
PEPTIDASE-1
(Bacillus
amyloliquefacien
s) 		3 / 3 ILE A 131
PRO A 132
ILE A 126
 None
 0.41A 5hw8F-1augA:
0.0		 5hw8F-1augA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 1aug PYROGLUTAMYL
PEPTIDASE-1
(Bacillus
amyloliquefacien
s) 		5 / 12 ASP A 206
ALA A 200
VAL A 198
GLY A 165
THR A 115
 None
 1.25A 5igiA-1augA:
0.0		 5igiA-1augA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR1_B_017B101_1
(PROTEASE PR5-DRV)		 1aug PYROGLUTAMYL
PEPTIDASE-1
(Bacillus
amyloliquefacien
s) 		5 / 10 LEU A   7
ALA A 200
ILE A 126
VAL A  69
ILE A  67
 None
 0.94A 5kr1A-1augA:
undetectable		 5kr1A-1augA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DIF_B_TPVB201_0
(HIV-1 PROTEASE)		 1aug PYROGLUTAMYL
PEPTIDASE-1
(Bacillus
amyloliquefacien
s) 		5 / 12 LEU A   7
ILE A 119
ILE A 195
VAL A  69
ILE A  67
 None
 1.17A 6difA-1augA:
undetectable		 6difA-1augA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_A_AM2A301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 1aug PYROGLUTAMYL
PEPTIDASE-1
(Bacillus
amyloliquefacien
s) 		4 / 8 HIS A 158
HIS A 146
GLU A 154
GLU A  56
 None
 1.20A 6mn4A-1augA:
0.0		 6mn4A-1augA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_B_AM2B301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 1aug PYROGLUTAMYL
PEPTIDASE-1
(Bacillus
amyloliquefacien
s) 		4 / 8 HIS A 158
HIS A 146
GLU A 154
GLU A  56
 None
 1.11A 6mn4B-1augA:
0.0		 6mn4B-1augA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_D_AM2D301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 1aug PYROGLUTAMYL
PEPTIDASE-1
(Bacillus
amyloliquefacien
s) 		4 / 8 HIS A 158
HIS A 146
GLU A 154
GLU A  56
 None
 1.11A 6mn4D-1augA:
0.0		 6mn4D-1augA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_F_AM2F301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 1aug PYROGLUTAMYL
PEPTIDASE-1
(Bacillus
amyloliquefacien
s) 		4 / 7 HIS A 158
HIS A 146
GLU A 154
GLU A  56
 None
 1.12A 6mn4F-1augA:
0.0		 6mn4F-1augA:
21.80