SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1aux'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_A_CIAA1003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 1aux SYNAPSIN IA
(Bos
taurus) 		5 / 11 TYR A 129
ALA A 127
PHE A 130
LEU A 116
GLN A 145
 None
 0.96A 1uduA-1auxA:
undetectable		 1uduA-1auxA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UHO_A_VDNA1000_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 1aux SYNAPSIN IA
(Bos
taurus) 		5 / 10 TYR A 129
ALA A 127
PHE A 130
LEU A 116
GLN A 145
 None
 1.01A 1uhoA-1auxA:
undetectable		 1uhoA-1auxA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOT_A_VDNA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 1aux SYNAPSIN IA
(Bos
taurus) 		5 / 12 MET A 414
LEU A 116
ILE A 406
PHE A 130
ILE A 141
 None
 1.10A 1xotA-1auxA:
undetectable		 1xotA-1auxA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_B_CLMB221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1aux SYNAPSIN IA
(Bos
taurus) 		5 / 12 SER A 390
SER A 212
LEU A 116
VAL A 143
VAL A 410
 None
 1.26A 3u9fB-1auxA:
0.0
3u9fC-1auxA:
0.0		 3u9fB-1auxA:
19.29
3u9fC-1auxA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_B_CLMB221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1aux SYNAPSIN IA
(Bos
taurus) 		5 / 12 SER A 390
SER A 212
VAL A 143
PHE A 130
VAL A 410
 None
 1.30A 3u9fB-1auxA:
0.0
3u9fC-1auxA:
0.0		 3u9fB-1auxA:
19.29
3u9fC-1auxA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_E_CLME221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1aux SYNAPSIN IA
(Bos
taurus) 		5 / 10 SER A 390
SER A 212
LEU A 116
VAL A 143
VAL A 410
 None
 1.36A 3u9fE-1auxA:
0.0		 3u9fE-1auxA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_E_CLME221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1aux SYNAPSIN IA
(Bos
taurus) 		5 / 10 SER A 390
SER A 212
VAL A 143
PHE A 130
VAL A 410
 None
 1.34A 3u9fE-1auxA:
0.0		 3u9fE-1auxA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_H_CLMH221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1aux SYNAPSIN IA
(Bos
taurus) 		5 / 12 SER A 390
SER A 212
LEU A 116
VAL A 143
VAL A 410
 None
 1.28A 3u9fH-1auxA:
0.0
3u9fI-1auxA:
0.0		 3u9fH-1auxA:
19.29
3u9fI-1auxA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_H_CLMH221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1aux SYNAPSIN IA
(Bos
taurus) 		5 / 12 SER A 390
SER A 212
VAL A 143
PHE A 130
VAL A 410
 None
 1.37A 3u9fH-1auxA:
0.0
3u9fI-1auxA:
0.0		 3u9fH-1auxA:
19.29
3u9fI-1auxA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_I_CLMI221_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1aux SYNAPSIN IA
(Bos
taurus) 		5 / 10 SER A 390
SER A 212
LEU A 116
VAL A 143
VAL A 410
 None
 1.29A 3u9fI-1auxA:
0.0		 3u9fI-1auxA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_I_CLMI221_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1aux SYNAPSIN IA
(Bos
taurus) 		5 / 10 SER A 390
SER A 212
VAL A 143
PHE A 130
VAL A 410
 None
 1.31A 3u9fI-1auxA:
0.0		 3u9fI-1auxA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_J_CLMJ221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1aux SYNAPSIN IA
(Bos
taurus) 		5 / 12 SER A 390
SER A 212
LEU A 116
VAL A 143
VAL A 410
 None
 1.28A 3u9fJ-1auxA:
0.0
3u9fK-1auxA:
0.0		 3u9fJ-1auxA:
19.29
3u9fK-1auxA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_J_CLMJ221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1aux SYNAPSIN IA
(Bos
taurus) 		5 / 12 SER A 390
SER A 212
VAL A 143
PHE A 130
VAL A 410
 None
 1.34A 3u9fJ-1auxA:
0.0
3u9fK-1auxA:
0.0		 3u9fJ-1auxA:
19.29
3u9fK-1auxA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_K_CLMK221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1aux SYNAPSIN IA
(Bos
taurus) 		5 / 10 SER A 390
SER A 212
LEU A 116
VAL A 143
VAL A 410
 None
 1.23A 3u9fK-1auxA:
0.0		 3u9fK-1auxA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_K_CLMK221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1aux SYNAPSIN IA
(Bos
taurus) 		5 / 10 SER A 390
SER A 212
VAL A 143
PHE A 130
VAL A 410
 None
 1.34A 3u9fK-1auxA:
0.0		 3u9fK-1auxA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_M_CLMM221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1aux SYNAPSIN IA
(Bos
taurus) 		5 / 10 SER A 390
SER A 212
VAL A 143
PHE A 130
VAL A 410
 None
 1.31A 3u9fM-1auxA:
0.0
3u9fN-1auxA:
0.0		 3u9fM-1auxA:
19.29
3u9fN-1auxA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_N_CLMN221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1aux SYNAPSIN IA
(Bos
taurus) 		5 / 11 SER A 390
SER A 212
LEU A 116
VAL A 143
VAL A 410
 None
 1.31A 3u9fN-1auxA:
0.0
3u9fO-1auxA:
0.0		 3u9fN-1auxA:
19.29
3u9fO-1auxA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_N_CLMN221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1aux SYNAPSIN IA
(Bos
taurus) 		5 / 11 SER A 390
SER A 212
VAL A 143
PHE A 130
VAL A 410
 None
 1.33A 3u9fN-1auxA:
0.0
3u9fO-1auxA:
0.0		 3u9fN-1auxA:
19.29
3u9fO-1auxA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_O_CLMO221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1aux SYNAPSIN IA
(Bos
taurus) 		5 / 11 SER A 390
SER A 212
VAL A 143
PHE A 130
VAL A 410
 None
 1.33A 3u9fM-1auxA:
0.0
3u9fO-1auxA:
0.0		 3u9fM-1auxA:
19.29
3u9fO-1auxA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_R_CLMR221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1aux SYNAPSIN IA
(Bos
taurus) 		5 / 10 SER A 390
SER A 212
LEU A 116
VAL A 143
VAL A 410
 None
 1.27A 3u9fR-1auxA:
0.0		 3u9fR-1auxA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_R_CLMR221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1aux SYNAPSIN IA
(Bos
taurus) 		5 / 10 SER A 390
SER A 212
VAL A 143
PHE A 130
VAL A 410
 None
 1.31A 3u9fR-1auxA:
0.0		 3u9fR-1auxA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_S_CLMS221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1aux SYNAPSIN IA
(Bos
taurus) 		5 / 12 SER A 390
SER A 212
LEU A 116
VAL A 143
VAL A 410
 None
 1.30A 3u9fP-1auxA:
0.0
3u9fS-1auxA:
0.0		 3u9fP-1auxA:
19.29
3u9fS-1auxA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_S_CLMS221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1aux SYNAPSIN IA
(Bos
taurus) 		5 / 12 SER A 390
SER A 212
VAL A 143
PHE A 130
VAL A 410
 None
 1.33A 3u9fP-1auxA:
0.0
3u9fS-1auxA:
0.0		 3u9fP-1auxA:
19.29
3u9fS-1auxA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UUU_A_SAMA1546_0
(CYSTATHIONINE
BETA-SYNTHASE)		 1aux SYNAPSIN IA
(Bos
taurus) 		5 / 11 LEU A 117
ASP A 120
GLN A 145
ALA A 146
HIS A 123
 None
 1.40A 4uuuA-1auxA:
0.0
4uuuB-1auxA:
0.0		 4uuuA-1auxA:
17.09
4uuuB-1auxA:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_A_ACTA612_0
(NADH DEHYDROGENASE,
PUTATIVE)		 1aux SYNAPSIN IA
(Bos
taurus) 		3 / 3 LYS A 403
ASP A 402
ARG A 186
 None
 1.08A 5jwaA-1auxA:
2.5
5jwaH-1auxA:
3.3		 5jwaA-1auxA:
20.42
5jwaH-1auxA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_B_Z80B401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 1aux SYNAPSIN IA
(Bos
taurus) 		5 / 9 ILE A 308
VAL A 267
GLU A 373
ASP A 313
ILE A 385
 AGS  A 800 (-3.9A)
AGS  A 800 ( 4.8A)
CA  A 801 ( 2.3A)
AGS  A 800 ( 4.4A)
AGS  A 800 (-4.3A)
 1.28A 5lg3B-1auxA:
undetectable		 5lg3B-1auxA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_C_Z80C401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 1aux SYNAPSIN IA
(Bos
taurus) 		5 / 9 ILE A 308
VAL A 267
GLU A 373
ASP A 313
ILE A 385
 AGS  A 800 (-3.9A)
AGS  A 800 ( 4.8A)
CA  A 801 ( 2.3A)
AGS  A 800 ( 4.4A)
AGS  A 800 (-4.3A)
 1.29A 5lg3C-1auxA:
undetectable		 5lg3C-1auxA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_D_Z80D401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 1aux SYNAPSIN IA
(Bos
taurus) 		5 / 9 ILE A 308
VAL A 267
GLU A 373
ASP A 313
ILE A 385
 AGS  A 800 (-3.9A)
AGS  A 800 ( 4.8A)
CA  A 801 ( 2.3A)
AGS  A 800 ( 4.4A)
AGS  A 800 (-4.3A)
 1.28A 5lg3D-1auxA:
0.0		 5lg3D-1auxA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_G_Z80G401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 1aux SYNAPSIN IA
(Bos
taurus) 		5 / 10 ILE A 308
VAL A 267
GLU A 373
ASP A 313
ILE A 385
 AGS  A 800 (-3.9A)
AGS  A 800 ( 4.8A)
CA  A 801 ( 2.3A)
AGS  A 800 ( 4.4A)
AGS  A 800 (-4.3A)
 1.27A 5lg3G-1auxA:
undetectable		 5lg3G-1auxA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MWY_A_YNUA1101_1
(MINERALOCORTICOID
RECEPTOR)		 1aux SYNAPSIN IA
(Bos
taurus) 		4 / 6 ARG A 328
CYH A 360
THR A 359
PHE A 244
 None
 1.30A 5mwyA-1auxA:
undetectable		 5mwyA-1auxA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFJ_A_SAMA501_0
(MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 1)		 1aux SYNAPSIN IA
(Bos
taurus) 		5 / 12 ILE A 319
GLY A 320
LEU A 184
LEU A 116
LEU A 405
 None
 0.94A 5nfjA-1auxA:
undetectable		 5nfjA-1auxA:
22.40