SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1avb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 1avb ARCELIN-1
(Phaseolus
vulgaris) 		5 / 10 VAL A 186
PHE A  69
VAL A 156
ILE A  54
LEU A 167
 None
 1.21A 1fe2A-1avbA:
undetectable		 1fe2A-1avbA:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSE_B_EAAB224_1
(GLUTATHIONE
TRANSFERASE)		 1avb ARCELIN-1
(Phaseolus
vulgaris) 		5 / 12 GLY A  44
LEU A  30
VAL A 216
LEU A  85
ALA A  86
 None
 1.07A 1gseB-1avbA:
undetectable		 1gseB-1avbA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG4_A_SAMA500_0
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 1avb ARCELIN-1
(Phaseolus
vulgaris) 		5 / 12 THR A  23
VAL A  24
SER A  25
GLY A 151
VAL A  35
 None
 1.12A 1jg4A-1avbA:
undetectable		 1jg4A-1avbA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JTX_A_CVIA200_0
(HYPOTHETICAL
TRANSCRIPTIONAL
REGULATOR IN QACA
5'REGION)		 1avb ARCELIN-1
(Phaseolus
vulgaris) 		5 / 12 TYR A 160
ILE A  54
ILE A  52
GLU A 193
ALA A 115
 None
 1.25A 1jtxA-1avbA:
undetectable		 1jtxA-1avbA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC2_D_NCAD510_0
(NAD-DEPENDENT
DEACETYLASE 2)		 1avb ARCELIN-1
(Phaseolus
vulgaris) 		4 / 5 PHE A 225
ASN A  55
ILE A  54
ASP A 194
 None
 1.17A 1yc2D-1avbA:
undetectable		 1yc2D-1avbA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC2_E_NCAE507_0
(NAD-DEPENDENT
DEACETYLASE 2)		 1avb ARCELIN-1
(Phaseolus
vulgaris) 		4 / 7 PHE A 225
ASN A  55
ILE A  54
ASP A 194
 None
 0.87A 1yc2E-1avbA:
undetectable		 1yc2E-1avbA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZG_B_NCAB302_0
(ADP-RIBOSYL CYCLASE
1)		 1avb ARCELIN-1
(Phaseolus
vulgaris) 		4 / 7 LEU A 105
ASP A 132
SER A 201
THR A 203
 None
 1.29A 3dzgB-1avbA:
undetectable		 3dzgB-1avbA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_B_9PLB1_1
(CYTOCHROME P450 2A13)		 1avb ARCELIN-1
(Phaseolus
vulgaris) 		4 / 6 PHE A 221
ASN A 224
PHE A  65
ALA A  63
 None
 1.06A 3t3sB-1avbA:
0.0		 3t3sB-1avbA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6E_A_SAMA1349_0
(HYDROXYINDOLE
O-METHYLTRANSFERASE)		 1avb ARCELIN-1
(Phaseolus
vulgaris) 		5 / 12 PHE A  65
GLY A 199
ILE A  52
VAL A 196
ALA A  86
 None
 1.08A 4a6eA-1avbA:
undetectable		 4a6eA-1avbA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNV_B_QI9B602_0
(CYTOCHROME P450 2D6)		 1avb ARCELIN-1
(Phaseolus
vulgaris) 		5 / 9 PHE A  11
LEU A  16
LEU A  85
THR A  70
PHE A  87
 None
 1.46A 4wnvB-1avbA:
0.0		 4wnvB-1avbA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GSN_A_MMZA503_1
(FLAVIN-CONTAINING
MONOOXYGENASE)		 1avb ARCELIN-1
(Phaseolus
vulgaris) 		3 / 3 ASN A  68
SER A  66
SER A 222
 NAG  A 400 (-1.8A)
NAG  A 400 (-3.1A)
None
 0.66A 5gsnA-1avbA:
undetectable		 5gsnA-1avbA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GSN_A_MMZA503_1
(FLAVIN-CONTAINING
MONOOXYGENASE)		 1avb ARCELIN-1
(Phaseolus
vulgaris) 		3 / 3 ASN A 224
SER A 222
SER A  66
 None
None
NAG  A 400 (-3.1A)
 0.78A 5gsnA-1avbA:
undetectable		 5gsnA-1avbA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KPC_B_SAMB401_0
(PAVINE
N-METHYLTRANSFERASE)		 1avb ARCELIN-1
(Phaseolus
vulgaris) 		5 / 12 GLY A  44
GLY A  20
ASN A  34
THR A 213
ALA A  46
 None
 1.17A 5kpcB-1avbA:
undetectable		 5kpcB-1avbA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OM2_B_DXTB501_1
(ALPHA-1-ANTICHYMOTRY
PSIN)		 1avb ARCELIN-1
(Phaseolus
vulgaris) 		5 / 9 VAL A 120
LEU A 167
ALA A 184
HIS A 181
ILE A 158
 None
 1.09A 5om2A-1avbA:
0.0
5om2B-1avbA:
undetectable		 5om2A-1avbA:
17.59
5om2B-1avbA:
11.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_G_CVIG301_0
(REGULATORY PROTEIN
TETR)		 1avb ARCELIN-1
(Phaseolus
vulgaris) 		5 / 12 ALA A 119
LEU A 188
ILE A  54
VAL A 198
PHE A 221
 None
 1.25A 5vlmG-1avbA:
undetectable		 5vlmG-1avbA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_B_NOVB403_1
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		 1avb ARCELIN-1
(Phaseolus
vulgaris) 		4 / 7 PHE A 106
ARG A 101
LEU A 103
ALA A 119
 None
 1.29A 6b89A-1avbA:
0.0		 6b89A-1avbA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_H_PCFH604_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 8
CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL)		 1avb ARCELIN-1
(Phaseolus
vulgaris) 		4 / 8 GLY A  84
VAL A 120
GLY A 147
ALA A 154
 None
 0.72A 6hu9H-1avbA:
0.0
6hu9e-1avbA:
undetectable		 6hu9H-1avbA:
16.20
6hu9e-1avbA:
21.83