SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1avo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_2
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 1avo 11S REGULATOR
(Homo
sapiens) 		3 / 3 LEU B 128
VAL B 131
LEU B 135
 None
 0.36A 1mz9B-1avoB:
1.1		 1mz9B-1avoB:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_A_VIVA301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 1avo 11S REGULATOR
11S REGULATOR
(Homo
sapiens;
Homo
sapiens) 		5 / 11 LEU A  40
ILE B 174
ILE B 121
VAL B 124
LEU B 167
 None
 1.09A 3w67A-1avoA:
undetectable		 3w67A-1avoA:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBQ_A_DIFA602_1
(SERUM ALBUMIN)		 1avo 11S REGULATOR
(Homo
sapiens) 		4 / 8 LEU B 167
ASN B 221
ALA B 222
VAL B 225
 None
 0.70A 4zbqA-1avoB:
undetectable		 4zbqA-1avoB:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D8P_B_ACTB804_0
(UNCHARACTERIZED
PROTEIN)		 1avo 11S REGULATOR
11S REGULATOR
(Homo
sapiens;
Homo
sapiens) 		4 / 4 HIS B 202
VAL B 104
LEU A  61
ALA A  59
 None
 1.35A 6d8pB-1avoB:
undetectable		 6d8pB-1avoB:
10.59