SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1avv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_B_CHDB5_0
(FERROCHELATASE)		 1avv NEGATIVE FACTOR
(Human
immunodeficiency
virus
1) 		3 / 3 PRO A 122
LEU A 112
ARG A 105
 None
 0.80A 3aqiB-1avvA:
undetectable		 3aqiB-1avvA:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_C_ACTC4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 1avv NEGATIVE FACTOR
(Human
immunodeficiency
virus
1) 		4 / 4 GLY A 132
GLY A 130
THR A 128
LEU A 198
 None
 0.65A 3si7C-1avvA:
undetectable
3si7D-1avvA:
undetectable		 3si7C-1avvA:
20.57
3si7D-1avvA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_D_ACTD4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 1avv NEGATIVE FACTOR
(Human
immunodeficiency
virus
1) 		4 / 5 LEU A 198
GLY A 132
GLY A 130
THR A 128
 None
 0.64A 3si7C-1avvA:
0.0
3si7D-1avvA:
undetectable		 3si7C-1avvA:
20.57
3si7D-1avvA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LVC_B_ADNB501_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))		 1avv NEGATIVE FACTOR
(Human
immunodeficiency
virus
1) 		4 / 5 GLN A 118
THR A 117
LEU A  97
LEU A  91
 None
 1.08A 4lvcB-1avvA:
undetectable		 4lvcB-1avvA:
14.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5K_B_ADNB502_2
(ADENOSYLHOMOCYSTEINA
SE)		 1avv NEGATIVE FACTOR
(Human
immunodeficiency
virus
1) 		4 / 4 GLN A 118
THR A 117
LEU A  97
LEU A  91
 None
 1.09A 5m5kB-1avvA:
undetectable		 5m5kB-1avvA:
14.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0O_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 1avv NEGATIVE FACTOR
(Human
immunodeficiency
virus
1) 		3 / 3 ALA A  84
GLN A 125
THR A 138
 None
 0.69A 5n0oA-1avvA:
undetectable		 5n0oA-1avvA:
18.39