SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1aw1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIK_A_ADNA799_1
(ADENOSINE KINASE)		 1aw1 TRIOSEPHOSPHATE
ISOMERASE
(Moritella
marina) 		5 / 10 GLY A 212
VAL A 215
ALA A 185
ASN A 219
ILE A 229
 PGA  A 290 ( 4.6A)
None
None
None
None
 0.98A 1likA-1aw1A:
undetectable		 1likA-1aw1A:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MMK_A_H4BA1427_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 1aw1 TRIOSEPHOSPHATE
ISOMERASE
(Moritella
marina) 		5 / 12 VAL A  20
LEU A  49
PHE A  46
LEU A  45
GLU A  17
 None
 1.47A 1mmkA-1aw1A:
undetectable		 1mmkA-1aw1A:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_C_URFC2081_1
(URIDINE
PHOSPHORYLASE)		 1aw1 TRIOSEPHOSPHATE
ISOMERASE
(Moritella
marina) 		4 / 7 GLY A 212
GLN A 210
MET A   7
ILE A 174
 PGA  A 290 ( 4.6A)
None
None
PGA  A 290 (-4.0A)
 0.95A 1rxcC-1aw1A:
undetectable		 1rxcC-1aw1A:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_D_URFD2021_1
(URIDINE
PHOSPHORYLASE)		 1aw1 TRIOSEPHOSPHATE
ISOMERASE
(Moritella
marina) 		4 / 7 GLY A 212
GLN A 210
MET A   7
ILE A 174
 PGA  A 290 ( 4.6A)
None
None
PGA  A 290 (-4.0A)
 0.93A 1rxcD-1aw1A:
undetectable		 1rxcD-1aw1A:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_I_URFI2041_1
(URIDINE
PHOSPHORYLASE)		 1aw1 TRIOSEPHOSPHATE
ISOMERASE
(Moritella
marina) 		4 / 8 GLY A 212
GLN A 210
MET A   7
ILE A 174
 PGA  A 290 ( 4.6A)
None
None
PGA  A 290 (-4.0A)
 0.96A 1rxcI-1aw1A:
undetectable		 1rxcI-1aw1A:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_F_ASDF1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 1aw1 TRIOSEPHOSPHATE
ISOMERASE
(Moritella
marina) 		4 / 8 PRO A 217
ALA A 237
ALA A 232
PHE A 224
 None
 0.82A 2vcvF-1aw1A:
0.0		 2vcvF-1aw1A:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_G_ASDG1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 1aw1 TRIOSEPHOSPHATE
ISOMERASE
(Moritella
marina) 		4 / 7 PRO A 217
ALA A 237
ALA A 232
PHE A 224
 None
 0.88A 2vcvG-1aw1A:
0.0		 2vcvG-1aw1A:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X1L_A_ADNA601_1
(METHIONYL-TRNA
SYNTHETASE)		 1aw1 TRIOSEPHOSPHATE
ISOMERASE
(Moritella
marina) 		5 / 11 ALA A 167
ALA A 232
GLY A 235
GLU A 169
HIS A  97
 None
None
PGA  A 290 (-3.4A)
PGA  A 290 (-2.8A)
PGA  A 290 (-4.0A)
 1.17A 2x1lA-1aw1A:
undetectable		 2x1lA-1aw1A:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_B_URFB254_1
(URIDINE
PHOSPHORYLASE)		 1aw1 TRIOSEPHOSPHATE
ISOMERASE
(Moritella
marina) 		4 / 6 GLY A 212
GLN A 210
MET A   7
ILE A 174
 PGA  A 290 ( 4.6A)
None
None
PGA  A 290 (-4.0A)
 1.00A 3kvvB-1aw1A:
undetectable		 3kvvB-1aw1A:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_C_URFC254_1
(URIDINE
PHOSPHORYLASE)		 1aw1 TRIOSEPHOSPHATE
ISOMERASE
(Moritella
marina) 		4 / 6 GLY A 212
GLN A 210
MET A   7
ILE A 174
 PGA  A 290 ( 4.6A)
None
None
PGA  A 290 (-4.0A)
 1.00A 3kvvC-1aw1A:
undetectable		 3kvvC-1aw1A:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_D_URFD254_1
(URIDINE
PHOSPHORYLASE)		 1aw1 TRIOSEPHOSPHATE
ISOMERASE
(Moritella
marina) 		4 / 6 GLY A 212
GLN A 210
MET A   7
ILE A 174
 PGA  A 290 ( 4.6A)
None
None
PGA  A 290 (-4.0A)
 0.98A 3kvvD-1aw1A:
undetectable		 3kvvD-1aw1A:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA1_A_08YA600_1
(CYTOCHROME P450 3A4)		 1aw1 TRIOSEPHOSPHATE
ISOMERASE
(Moritella
marina) 		5 / 12 ILE A  61
THR A 124
PHE A 244
ALA A 245
ALA A 251
 None
 1.19A 3ua1A-1aw1A:
undetectable		 3ua1A-1aw1A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DX7_B_DM2B1104_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 1aw1 TRIOSEPHOSPHATE
ISOMERASE
(Moritella
marina) 		4 / 8 GLN A 148
GLU A 131
ILE A 196
VAL A 207
 None
 0.95A 4dx7B-1aw1A:
undetectable		 4dx7B-1aw1A:
15.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OF1_A_SALA301_1
(SPORE
COAT-ASSOCIATED
PROTEIN N)		 1aw1 TRIOSEPHOSPHATE
ISOMERASE
(Moritella
marina) 		4 / 5 ALA A 164
VAL A 207
PHE A 115
ILE A 196
 None
 0.95A 5of1A-1aw1A:
0.0		 5of1A-1aw1A:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OF1_B_SALB301_1
(SPORE
COAT-ASSOCIATED
PROTEIN N)		 1aw1 TRIOSEPHOSPHATE
ISOMERASE
(Moritella
marina) 		4 / 5 ALA A 164
VAL A 207
PHE A 115
ILE A 196
 None
 1.03A 5of1B-1aw1A:
0.0		 5of1B-1aw1A:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCG_A_08YA602_1
(CYTOCHROME P450 3A4)		 1aw1 TRIOSEPHOSPHATE
ISOMERASE
(Moritella
marina) 		5 / 12 ILE A  61
THR A 124
PHE A 244
ALA A 245
ALA A 251
 None
 1.27A 5vcgA-1aw1A:
undetectable		 5vcgA-1aw1A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HXI_D_ACTD703_0
(SUCCINYL-COA LIGASE
(ADP-FORMING)
SUBUNIT ALPHA)		 1aw1 TRIOSEPHOSPHATE
ISOMERASE
(Moritella
marina) 		4 / 5 HIS A 104
ARG A 100
ASP A  69
PHE A 110
 None
 1.17A 6hxiD-1aw1A:
0.1		 6hxiD-1aw1A:
18.01