SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1awb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SA1_B_PODB700_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 1awb MYO-INOSITOL
MONOPHOSPHATASE
(Homo
sapiens) 		5 / 12 VAL A 193
LEU A 235
ALA A 252
ASN A 199
VAL A 148
 None
 1.09A 1sa1A-1awbA:
undetectable
1sa1B-1awbA:
undetectable		 1sa1A-1awbA:
21.51
1sa1B-1awbA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SA1_D_PODD701_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 1awb MYO-INOSITOL
MONOPHOSPHATASE
(Homo
sapiens) 		5 / 12 VAL A 193
LEU A 235
ALA A 252
ASN A 199
VAL A 148
 None
 1.07A 1sa1C-1awbA:
undetectable
1sa1D-1awbA:
undetectable		 1sa1C-1awbA:
21.51
1sa1D-1awbA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_B_BEZB12_0
(CES1 PROTEIN)		 1awb MYO-INOSITOL
MONOPHOSPHATASE
(Homo
sapiens) 		4 / 4 GLY A 215
SER A 165
VAL A 175
LEU A 271
 None
IPD  A 281 ( 3.8A)
None
None
 1.36A 1yajB-1awbA:
undetectable		 1yajB-1awbA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXM_A_IMNA2002_1
(SERUM ALBUMIN)		 1awb MYO-INOSITOL
MONOPHOSPHATASE
(Homo
sapiens) 		5 / 11 ILE A 227
LEU A 146
PHE A 140
ARG A 134
GLY A 138
 None
 1.30A 2bxmA-1awbA:
1.2		 2bxmA-1awbA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FXE_A_DR7A102_1
(POL PROTEIN)		 1awb MYO-INOSITOL
MONOPHOSPHATASE
(Homo
sapiens) 		5 / 12 GLY A 207
ALA A 208
ASP A 209
GLY A 189
VAL A 193
 None
None
None
CL  A 280 ( 4.1A)
None
 0.71A 2fxeA-1awbA:
undetectable		 2fxeA-1awbA:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_L_TACL6888_1
(ELONGATION FACTOR
EF-TU)		 1awb MYO-INOSITOL
MONOPHOSPHATASE
(Homo
sapiens) 		4 / 6 SER A 124
VAL A 126
THR A 195
ASP A  93
 None
None
None
IPD  A 281 (-3.0A)
 1.24A 2hdnJ-1awbA:
undetectable
2hdnK-1awbA:
0.0
2hdnL-1awbA:
undetectable		 2hdnJ-1awbA:
21.94
2hdnK-1awbA:
9.80
2hdnL-1awbA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OBV_A_SAMA501_0
(S-ADENOSYLMETHIONINE
SYNTHETASE ISOFORM
TYPE-1)		 1awb MYO-INOSITOL
MONOPHOSPHATASE
(Homo
sapiens) 		4 / 8 PRO A  91
ASP A  90
SER A 165
ASP A  47
 CA  A   1 ( 4.9A)
CA  A 278 (-2.7A)
IPD  A 281 ( 3.8A)
None
 0.99A 2obvA-1awbA:
undetectable		 2obvA-1awbA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_A_SAMA500_1
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 1awb MYO-INOSITOL
MONOPHOSPHATASE
(Homo
sapiens) 		4 / 6 THR A  96
THR A 195
ASP A 220
ASP A 274
 None
None
CA  A 278 (-2.9A)
None
 1.18A 2okcA-1awbA:
undetectable		 2okcA-1awbA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XH9_A_J01A1437_1
(ORF12)		 1awb MYO-INOSITOL
MONOPHOSPHATASE
(Homo
sapiens) 		5 / 11 SER A 108
TYR A 211
ALA A 224
GLY A 223
ALA A 222
 None
 1.45A 2xh9A-1awbA:
0.0		 2xh9A-1awbA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XH9_B_J01B1437_1
(ORF12)		 1awb MYO-INOSITOL
MONOPHOSPHATASE
(Homo
sapiens) 		5 / 10 SER A 108
TYR A 211
ALA A 224
GLY A 223
ALA A 222
 None
 1.44A 2xh9B-1awbA:
1.8		 2xh9B-1awbA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_E_ACHE1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 1awb MYO-INOSITOL
MONOPHOSPHATASE
(Homo
sapiens) 		4 / 7 ILE A 109
SER A  57
TYR A  62
TYR A  11
 None
 1.43A 2xz5D-1awbA:
0.0
2xz5E-1awbA:
0.0		 2xz5D-1awbA:
21.22
2xz5E-1awbA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZGW_A_ADNA1301_1
(BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 1awb MYO-INOSITOL
MONOPHOSPHATASE
(Homo
sapiens) 		4 / 7 GLU A 260
ALA A 210
ASN A 255
ALA A 253
 None
 1.08A 2zgwA-1awbA:
0.0		 2zgwA-1awbA:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZGW_B_ADNB1302_1
(BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 1awb MYO-INOSITOL
MONOPHOSPHATASE
(Homo
sapiens) 		4 / 6 GLU A 260
ALA A 210
ASN A 255
ALA A 253
 None
 1.09A 2zgwB-1awbA:
0.0		 2zgwB-1awbA:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM6_A_017A200_1
(PROTEASE)		 1awb MYO-INOSITOL
MONOPHOSPHATASE
(Homo
sapiens) 		4 / 8 GLY A 207
ALA A 208
ASP A 209
VAL A 193
 None
 0.53A 3em6A-1awbA:
0.0		 3em6A-1awbA:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_B_TMQB612_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1awb MYO-INOSITOL
MONOPHOSPHATASE
(Homo
sapiens) 		5 / 9 VAL A 160
ALA A 210
ILE A 154
ILE A 190
TYR A 212
 None
 1.41A 3hbbB-1awbA:
undetectable		 3hbbB-1awbA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_A_SALA3002_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 1awb MYO-INOSITOL
MONOPHOSPHATASE
(Homo
sapiens) 		5 / 8 HIS A 217
VAL A 250
ILE A 216
VAL A 221
LEU A 245
 None
None
IPD  A 281 (-4.9A)
None
None
 1.42A 3kp6A-1awbA:
undetectable
3kp6B-1awbA:
0.0		 3kp6A-1awbA:
19.42
3kp6B-1awbA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFN_A_ROCA401_2
(HIV-1 PROTEASE)		 1awb MYO-INOSITOL
MONOPHOSPHATASE
(Homo
sapiens) 		4 / 7 ARG A 101
VAL A 198
GLY A 194
VAL A 126
 None
None
IPD  A 281 (-4.3A)
None
 0.82A 3ufnB-1awbA:
0.0		 3ufnB-1awbA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW1_D_CVID301_0
(PUTATIVE REGULATORY
PROTEIN)		 1awb MYO-INOSITOL
MONOPHOSPHATASE
(Homo
sapiens) 		5 / 12 LEU A 182
ILE A 251
TYR A 212
ILE A 190
VAL A 228
 None
 1.28A 3vw1D-1awbA:
0.1		 3vw1D-1awbA:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTT_A_SAMA405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 1awb MYO-INOSITOL
MONOPHOSPHATASE
(Homo
sapiens) 		4 / 8 PRO A  91
ASP A  90
SER A 165
ASP A  47
 CA  A   1 ( 4.9A)
CA  A 278 (-2.7A)
IPD  A 281 ( 3.8A)
None
 1.03A 4kttA-1awbA:
undetectable		 4kttA-1awbA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTT_C_SAMC404_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 1awb MYO-INOSITOL
MONOPHOSPHATASE
(Homo
sapiens) 		4 / 8 PRO A  91
ASP A  90
SER A 165
ASP A  47
 CA  A   1 ( 4.9A)
CA  A 278 (-2.7A)
IPD  A 281 ( 3.8A)
None
 1.02A 4kttC-1awbA:
undetectable		 4kttC-1awbA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NDN_A_SAMA407_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 1awb MYO-INOSITOL
MONOPHOSPHATASE
(Homo
sapiens) 		4 / 8 PRO A  91
ASP A  90
SER A 165
ASP A  47
 CA  A   1 ( 4.9A)
CA  A 278 (-2.7A)
IPD  A 281 ( 3.8A)
None
 0.99A 4ndnA-1awbA:
undetectable		 4ndnA-1awbA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NDN_C_SAMC405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 1awb MYO-INOSITOL
MONOPHOSPHATASE
(Homo
sapiens) 		4 / 7 PRO A  91
ASP A  90
SER A 165
ASP A  47
 CA  A   1 ( 4.9A)
CA  A 278 (-2.7A)
IPD  A 281 ( 3.8A)
None
 1.04A 4ndnC-1awbA:
undetectable		 4ndnC-1awbA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODJ_A_SAMA500_0
(S-ADENOSYLMETHIONINE
SYNTHASE)		 1awb MYO-INOSITOL
MONOPHOSPHATASE
(Homo
sapiens) 		4 / 7 PRO A  91
ASP A  90
SER A 165
ASP A  47
 CA  A   1 ( 4.9A)
CA  A 278 (-2.7A)
IPD  A 281 ( 3.8A)
None
 1.08A 4odjA-1awbA:
undetectable		 4odjA-1awbA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUC_A_SAMA303_0
(CATECHOL
O-METHYLTRANSFERASE)		 1awb MYO-INOSITOL
MONOPHOSPHATASE
(Homo
sapiens) 		5 / 12 MET A 200
ASN A 199
VAL A 198
ILE A  89
ILE A  88
 None
 1.42A 4xucA-1awbA:
undetectable		 4xucA-1awbA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUE_A_SAMA303_0
(CATECHOL
O-METHYLTRANSFERASE)		 1awb MYO-INOSITOL
MONOPHOSPHATASE
(Homo
sapiens) 		5 / 12 MET A 200
ASN A 199
VAL A 198
ILE A  89
ILE A  88
 None
 1.38A 4xueA-1awbA:
undetectable		 4xueA-1awbA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A1I_A_ADNA407_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 1awb MYO-INOSITOL
MONOPHOSPHATASE
(Homo
sapiens) 		4 / 8 PRO A  91
ASP A  90
SER A 165
ASP A  47
 CA  A   1 ( 4.9A)
CA  A 278 (-2.7A)
IPD  A 281 ( 3.8A)
None
 1.02A 5a1iA-1awbA:
undetectable		 5a1iA-1awbA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A1I_A_SAMA405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 1awb MYO-INOSITOL
MONOPHOSPHATASE
(Homo
sapiens) 		4 / 7 PRO A  91
ASP A  90
SER A 165
ASP A  47
 CA  A   1 ( 4.9A)
CA  A 278 (-2.7A)
IPD  A 281 ( 3.8A)
None
 1.02A 5a1iA-1awbA:
undetectable		 5a1iA-1awbA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_A_SAMA301_0
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 1awb MYO-INOSITOL
MONOPHOSPHATASE
(Homo
sapiens) 		5 / 12 GLY A 110
TYR A 123
ILE A  68
ALA A 112
ALA A 222
 None
 1.02A 5kvaA-1awbA:
undetectable		 5kvaA-1awbA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_B_SAMB301_0
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 1awb MYO-INOSITOL
MONOPHOSPHATASE
(Homo
sapiens) 		5 / 12 GLY A 110
TYR A 123
ILE A  68
ALA A 112
ALA A 222
 None
 1.03A 5kvaB-1awbA:
undetectable		 5kvaB-1awbA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZMQ_K_PACK1_0
(SERINE PROTEASE NS3
PEPTIDE
PAC-DLY-DLY-DAR)		 1awb MYO-INOSITOL
MONOPHOSPHATASE
(Homo
sapiens) 		3 / 3 ALA A 224
VAL A 160
TYR A 211
 None
 0.70A 5zmqH-1awbA:
0.2		 5zmqH-1awbA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_A_EY4A502_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 1awb MYO-INOSITOL
MONOPHOSPHATASE
(Homo
sapiens) 		4 / 7 ALA A 133
THR A 132
TYR A 131
GLN A 147
 None
 0.89A 6cduA-1awbA:
0.0
6cduE-1awbA:
0.0		 6cduA-1awbA:
22.71
6cduE-1awbA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_E_EY4E500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 1awb MYO-INOSITOL
MONOPHOSPHATASE
(Homo
sapiens) 		4 / 8 GLN A 147
ALA A 133
THR A 132
TYR A 131
 None
 0.92A 6cduD-1awbA:
0.0
6cduE-1awbA:
0.0		 6cduD-1awbA:
22.71
6cduE-1awbA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_H_EY4H500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 1awb MYO-INOSITOL
MONOPHOSPHATASE
(Homo
sapiens) 		4 / 7 GLN A 147
ALA A 133
THR A 132
TYR A 131
 None
 0.92A 6cduH-1awbA:
3.0
6cduI-1awbA:
0.0		 6cduH-1awbA:
22.71
6cduI-1awbA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJ1_B_AB1B201_0
(HIV-1 PROTEASE)		 1awb MYO-INOSITOL
MONOPHOSPHATASE
(Homo
sapiens) 		5 / 12 GLY A 207
ALA A 208
ASP A 209
GLY A 189
VAL A 193
 None
None
None
CL  A 280 ( 4.1A)
None
 0.65A 6dj1A-1awbA:
undetectable		 6dj1A-1awbA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBN_B_SAMB401_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 1awb MYO-INOSITOL
MONOPHOSPHATASE
(Homo
sapiens) 		4 / 8 PRO A  91
ASP A  90
SER A 165
ASP A  47
 CA  A   1 ( 4.9A)
CA  A 278 (-2.7A)
IPD  A 281 ( 3.8A)
None
 1.11A 6fbnB-1awbA:
undetectable		 6fbnB-1awbA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBO_A_ADNA406_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 1awb MYO-INOSITOL
MONOPHOSPHATASE
(Homo
sapiens) 		4 / 8 PRO A  91
ASP A  90
SER A 165
ASP A  47
 CA  A   1 ( 4.9A)
CA  A 278 (-2.7A)
IPD  A 281 ( 3.8A)
None
 1.02A 6fboA-1awbA:
undetectable		 6fboA-1awbA:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FCB_A_SAMA405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 1awb MYO-INOSITOL
MONOPHOSPHATASE
(Homo
sapiens) 		4 / 8 PRO A  91
ASP A  90
SER A 165
ASP A  47
 CA  A   1 ( 4.9A)
CA  A 278 (-2.7A)
IPD  A 281 ( 3.8A)
None
 0.98A 6fcbA-1awbA:
undetectable		 6fcbA-1awbA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FCD_A_ADNA405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 1awb MYO-INOSITOL
MONOPHOSPHATASE
(Homo
sapiens) 		4 / 8 PRO A  91
ASP A  90
SER A 165
ASP A  47
 CA  A   1 ( 4.9A)
CA  A 278 (-2.7A)
IPD  A 281 ( 3.8A)
None
 1.02A 6fcdA-1awbA:
undetectable		 6fcdA-1awbA:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G6R_A_SAMA406_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 1awb MYO-INOSITOL
MONOPHOSPHATASE
(Homo
sapiens) 		4 / 7 PRO A  91
ASP A  90
SER A 165
ASP A  47
 CA  A   1 ( 4.9A)
CA  A 278 (-2.7A)
IPD  A 281 ( 3.8A)
None
 1.01A 6g6rA-1awbA:
undetectable		 6g6rA-1awbA:
18.99